Syntéza a antimikrobiální vlastnosti derivátů 2-[(7-ethyl-3-methylxanthin-8-yl)sulfanyl]acetohydraziduOriginal articles # E-publication

Dmytro Ivanchenko, Mykola Romanenko, Olha Pakhomova, Oleksandra Cherchesova, Natalia Rudko, Natalia Voronova, Horban Valerii

Čes. slov. farm. 2026, 75(1):E20-E26 | DOI: 10.36290/csf.2026.011

Antimikrobiální rezistence (AMR) představuje zásadní globální zdravotní hrozbu, která podněcuje naléhavé hledání nových terapeutických látek. Hybridní molekuly založené na xanthinových a 1,2,4-triazolových skeletech představují slibný směr díky svým potenciálním multitargetovým antimikrobiálním účinkům. Tato studie měla za cíl syntetizovat nové deriváty 2-[(7-ethyl-3-methylxanthin-8-yl)sulfanyl]acetohydrazidu obsahující 1,2,4-triazolové zbytky, charakterizovat jejich struktury a vyhodnotit jejich antimikrobiální a protiplísňové vlastnosti. Byla syntetizována řada dosud nepopsaných sloučenin za použití N-substituovaných isothiokyanátů a následných...

Drug unavailability increases off-label prescribing in the pediatric population in SlovakiaOriginal articles # E-publication

Michala Hrončová, Simona Valášková, Andrea Gažová

Čes. slov. farm. 2026, 75(1):E12-E18 | DOI: 10.36290/csf.2026.010

Drug shortages may lead to interruption of ongoing treatment, delays in therapy initiation, or the need to modify therapeutic regimens. This represents a current and persistent problem that requires systematic and long-term solutions, as it may be a significant contributing factor to off-label prescribing. Between 2018 and 2020, the occurrence of drug shortages increased up to twentyfold, accompanied by a growing demand for essential medicines. The aim of this study was to analyse the occurrence of off-label prescribing in the paediatric population in a community pharmacy and to assess a possible association between the unavailability of a selected...

Skin hydration: How to increase the water content in the skin with dermocosmetics?Self medication#E-publication

Andrej Kováčik, Barbora Vraníková, Robert Čáp

Čes. slov. farm. 2026, 75(1):E8-E11 | DOI: 10.36290/csf.2026.002

The ability of skin to retain water and its hydration are essential for both the appearance and function of the skin barrier. Dry skin occurs when natural hydration mechanisms are impaired, accompanied by a loss of elasticity, scaling and an unpleasant feeling of tightness. The aim of this article is to explain the mechanisms of skin hydration and describe the properties of moisturizing cosmetic products. The article discusses the mechanisms of action and examples of cosmetic humectants, emollients, and occlusives that prevent transepidermal water loss. Moisturizing cosmetics containing these ingredients are therefore essential for restoring and maintaining...

Where did history of the pharmacy go?From the history of pharmacy and healthcare # E-publication

Sixtus Bolom-Kotari, Jindřich Kolda

Čes. slov. farm. 2026, 75(1):E2-E7 | DOI: 10.36290/csf.2026.001

The text is based on the authors' paper at this year's LXXth Symposium on the History of Pharmacy (24/05/2025, Kuks) and summarizes their arguments as to why contemporary Czech pharmaceutical historiography is in an attenuation (decline?) and what are the possible paths to its re-flourishing. The authors see the cause of this situation in an overly narrow conception of the field, focused exclusively on strictly pharmaceutical matters, further in a certain preference for pharmaceutical education as a prerequisite for research into the history of the field and, last but not least, a impression that the picture of the history of pharmacy is already more...

Již 155 let pomáháme rozvíjet farmaciiEditorial

prof. PharmDr. Martin Doležal, Ph.D.

Čes. slov. farm. 2026, 75(1):3

Fixní kombinace antihypertenziv, adherence a rizika záměny v klinické praxiCompany information

PharmDr. Josef Suchopár, Mgr. Štěpán Suchopár

Čes. slov. farm. 2026, 75(1):62-64

Střípky z XXVII. sympozia klinické farmacie René MachaNews from Czech Pharmaceutical Society

Kateřina Zyková, Markéta Dresslerová, Eliška Kolmanová

Čes. slov. farm. 2026, 75(1):55-60

Ocular manifestations of allergies - options for self-treatmentSelf medication

Martina Čudová, Jana Melicharová, Tereza Kauerová

Čes. slov. farm. 2026, 75(1):48-53 | DOI: 10.36290/csf.2026.009

Ocular allergies, the majority of which are seasonal allergic conjunctivitis, are one of the most common ocular conditions for which patients seek professional help. These allergies mainly affect the structures of the anterior segment of the eye, including the conjunctiva, cornea, eyelids, or lacrimal glands. Patients may experience a range of symptoms, from mild to severe, and in some cases, chronic forms of the condition can lead to gradual vision impairment. Currently, several over-the-counter medications containing antihistamines, mast cell stabilizers, and decongestants are available for the treatment of ocular allergies, when used in combination...

Sinusitis self-treatmentSelf medication

Tomáš Hammer

Čes. slov. farm. 2026, 75(1):42-47 | DOI: 10.36290/csf.2026.008

Inflammation of the paranasal sinuses is a common respiratory tract disease and a frequent reason for visiting the pharmacy. In most cases, acute sinusitis is of viral origin, treatment is aimed at alleviating symptoms and does not require physician intervention. The article briefly summarizes the groups of over-the-counter products suitable for self-treatment of acute sinusitis, their use and limitations, complementary non-pharmacological measures, and situations where self-treatment is no longer sufficient.

Pelargonium sidoides DC. vs. Pelargonium reniforme (Andrews) Curtis -active constituents and medicinal effectsMedicinal plants and nutraceutics

Zdeňka Navrátilová

Čes. slov. farm. 2026, 75(1):35-41 | DOI: 10.36290/csf.2026.007

Pelargonium sidoides and Pelargonium reniforme are two closely related species of geraniums growing in Southern Africa. The species belong to the section Reniformia and are morphologically quite similar and often confused. Both species are used for medicinal purposes, but differ in the representation of the compounds and pharmacological effects. The article summarizes information about their composition and medicinal effects and compare it.

Effective communication in the pharmacySocial pharmacy

Pavel Novák

Čes. slov. farm. 2026, 75(1):30-33 | DOI: 10.36290/csf.2026.006

The text summarizes the principles of effective communication in pharmacy practice and emphasizes its key role in ensuring the safe and high-quality provision of pharmaceutical services. The introduction provides a detailed description of verbal, paraverbal, and nonverbal communication elements, including their interaction in everyday patient interactions. The text further describes internal and external communication barriers that may disrupt or hinder information exchange. Significant attention is given to empathy and active listening, which enable pharmacists to better understand the needs, concerns, and expectations of patients. Active listening...

Artificial intelligence in pharmacy services - practical applicationsSocial pharmacy

Milan Rydrych

Čes. slov. farm. 2026, 75(1):24-29 | DOI: 10.36290/csf.2026.005

Introduction: Paper presents the principles of modern artificial intelligence (AI), its current capabilities, limitations, and practical applications in pharmacy. The text outlines the development of AI, explains key terms, and introduces the most important models and their capabilities. Objective: The objective of the article is to show how AI can support pharmaceutical practice, where its limits lie, and what legislative and safety requirements must be respected when using it. Results: Modern AI models enable text generation, data processing, image analysis, and decision support. In pharmacy, they can speed up data analysis (e.g., LEK-13 reports),...

Pharmacokinetic changes and approach to drug dosing in patients with obesity and after bariatric surgeryReview articles

Alena Pilková

Čes. slov. farm. 2026, 75(1):16-23 | DOI: 10.36290/csf.2026.004

Introduction: Obesity is a chronic disease associated with multiple comorbidities and can affect drug pharmacokinetics. Appropriate dosing in obese patients is essential to ensure therapeutic efficacy and safety. Objective: To summarize the impact of obesity and bariatric surgery on drug pharmacokinetics and provide recommendations for individualized dosing. Methods: Review of available literature and clinical guidelines addressing changes in drug absorption, distribution, metabo­lism, and excretion in obese patients and after bariatric procedures. Results: Obesity is associated with nonlinear changes in volume of distribution and heterogenous changes...

Idiopathic interstitial lung diseases - treatment optionsCurrent pharmacotherapy

Martina Šterclová

Čes. slov. farm. 2026, 75(1):8-13 | DOI: 10.36290/csf.2026.003

Idiopathic interstitial pneumonias (IIPs) represent a heterogeneous group of rare lung diseases characterized by distinct radiological and histological phenotypes. The new 2025 classification provides a more detailed definition of individual entities, including the incorporation of idiopathic eosinophilic pneumonias and rare forms, without yet altering current therapeutic approaches. The most common form is idiopathic pulmonary fibrosis (IPF), where antifibrotic therapy with pirfenidone and nintedanib has been shown to improve prognosis. Recent clinical trials (FIBRONEER, TETON) suggest further therapeutic options. The treatment of other IIPs, particularly...

The feminization of Czech pharmacy in the 20th centuryFrom the history of pharmacy and healthcare # E-publication

Ladislav Svatoš, Ladislava Valášková, Martina Borovičková

Čes. slov. farm. 2025, 74(4):E15-E20 | DOI: 10.36290/csf.2025.046

Contemporary pharmacy in the Czech Republic is substantially feminized profession. This article describes the process of feminization since permission for women to study pharmacy in 1900 till 2000, based on data analysis, in three aspects – number of graduates from Czech universities, number of women working in pharmacies and number of women among pharmacy owners / managers. Women predominate among graduates since after the World War II, as pharmacy workers since 1950s and pharmacy managers since 1980s. At the end of the analyzed period of time, women constituted as many as 80 % of graduates and pharmacy workers and 70% of pharmacy managers...

Organizational challenges and benefits of electronic prescriptions in physicians’ daily practice: Survey findings from UkraineOriginal articles # E-publication

Uliana Khomut, Iryna Fediak

Čes. slov. farm. 2025, 74(4):E8-E14 | DOI: 10.36290/csf.2025.037

Background: Electronic prescriptions (e-prescriptions) are a key element of the digital transformation of Ukraine’s healthcare system. However, their implementation and usage levels vary significantly depending on the physician’s specialty, years of experience, and the type of locality. This study is relevant due to the need for empirical analysis of these differences to improve the e-prescription system and enhance its overall efficiency. Objective: To assess the impact of e-prescriptions on the workflow of physicians from various specialties and to identify patterns associated with location, professional experience,...

Efficacy of quercetin and the role of endothelial protection in the treatment of patients with arterial hypertensionOriginal articles # E-publication

Valentyna Volodymyrivna Chopyak, Igor Grygorovich Hayduchok, Yuriy Volodymyrovych Fedorov, Alona Vasylivna Kovpak, Bogdana Fedorivna Baida, Oksana Volodymyrivna Levytska, Volodymyr Antonovych Doroshko

Čes. slov. farm. 2025, 74(4):E2-E7 | DOI: 10.36290/csf.2025.036

Introduction: The article presents the findings of a clinical trial investigating the impact of quercetin, as an adjunct to antihypertensive therapy, on endothelial function and daily blood pressure profiles. The aim of the study. To conduct a comparative analysis of the impact of quercetin on 24-hour blood pressure monitoring parameters and cytokine profiles in patients with hypertension. Materials and methods: A total of 120 patients with stage II hypertension (66 female and 54 male) were enrolled in the study. Patients were divided into 2 groups: Group I (study) – 58 patients who took quercetin (Corvitin®) in...

I „kosmetická“ změna v terapii arteriální hypertenze může přinést velký (a ne vždy chtěný) klinický účinekCompany information

MUDr. Pavel Rutar

Čes. slov. farm. 2025, 74(4):276-278

Role Subkatedry klinické farmacie v systému specializačního vzdělávání farmaceutů v České republiceEditorial

PharmDr. Martina Maříková, Ph.D.

Čes. slov. farm. 2025, 74(4):219

Topical application of vitamin C and its derivatives in dermatology and cosmeticsSelf medication

Hana Hořavová, Kateřina Brückner

Čes. slov. farm. 2025, 74(4):272-275 | DOI: 10.36290/csf.2025.044

Vitamin C (ascorbic acid) is a highly valued bioactive substance with extensive use in dermatology and cosmetics. Its main effects are strong antioxidant capacity, collagen synthesis boosting, depigmentation effect and improvement of the skin barrier. Due to these properties, it is a popular ingredient in preparations intended for the prevention of aging and correction of photodamage. Despite its biological efficacy, topical use of vitamin C represents a technological challenge due to its low stability and limited ability to penetrate the skin. The work summarizes the key factors influencing its efficacy - including concentration, pH, formulation and...

Self-treatment of cough in respiratory infectionsSelf medication

Hana Kotolová

Čes. slov. farm. 2025, 74(4):264-271 | DOI: 10.36290/csf.2025.043

Cough is one of the most common symptoms with which patients search pharmaceutical care. Most cases have a viral etiology and do not require medical intervention, therefore the pharmacist has a key role in patient education and in recommending appropriate self-treatment. Correct differentiation of the type of cough and selection of appropriate treatment can significantly shorten the duration of the problem and prevent further complications. For dry cough, short-term administration of antitussives is appropriate, while for wet cough, mucolytics or expectorants are recommended. Regimen measures are also an integral part of self-treatment.

Bioactive compounds with adjuvant therapeutic potential in neurodegenerative diseases and peripheral neuropathyPhytotherapy and nutraceuticals

Alice Sychrová

Čes. slov. farm. 2025, 74(4):258-262 | DOI: 10.36290/csf.2025.042

Introduction: Neurodegenerative diseases and peripheral neuropathies share several common pathophysiological mechanisms, including oxidative stress, neuroinflammation, and mitochondrial dysfunction. Although their clinical manifestations differ, similar neuroprotective therapeutic approaches are applied in both conditions. Aim: The aim of this review is to summarize current knowledge on the use of nutraceuticals and vitamin supplementation as adjuvant strategies in the prevention and treatment of neurodegenerative diseases and peripheral neuropathies. Methods: The literature review focused on studies evaluating the efficacy, mechanisms of action,...

Selected case reports from the practice of a clinical pharmacist in the field of pneumologyCase reports from pharmacy practice

Blanka Pelantová, Petra Halvová, Petra Rozsívalová, Lenka Dejdarová, Vladimír Koblížek, Filip Gabalec, Josef Malý

Čes. slov. farm. 2025, 74(4):252-257 | DOI: 10.36290/csf.2025.041

This article presents three case studies highlighting complex pharmacotherapeutic challenges and the role of a clinical pharmacist in clinical practice. The first case describes the long-term treatment of avian mycobacteriosis (MAC - Mycobacterium avium complex) in a patient with cystic fibrosis. It details the patient's history of multi-drug resistant MAC infection, numerous antituberculosis regimens, and significant drug intolerances, emphasizing the need for careful consideration of drug interactions, particularly with cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The second case focuses on the management of a drug...

Choosing wisely in practice: How sick day rules help prevent medication-related complicationsFor the practice of a clinical pharmacist

Petra Rozsívalová, Petra Šubrtová, Karolína Russ, Petr Grenar, Jiří Nový, Dan Rakušan, Jiří Cyrany, Kateřina Langmaierová

Čes. slov. farm. 2025, 74(4):244-251 | DOI: 10.36290/csf.2025.040

Introduction and Aim: Sick Day Rules represent a practical multidisciplinary procedure for temporarily adjusting or suspending certain medications during an acute illness to prevent drug-related complications, especially acute kidney injury. This article aims to introduce the international concept of Sick Day Rules and proposes its application in Czech clinical practice. Methods: Literature search and analysis in the PubMed and Google Scholar databases using keywords focused on Sick Day Rules, prevention of medication-related complications, and medicine re-initiation during acute illness. Resources used included consensus documents, clinical reviews,...

Radiopharmaceutical ⁶⁸Ga-PSMA-11 for prostate cancer diagnosticsPharmaceutical technology

Michal Budinský, Ján Melicherík, Petr Vyšinský

Čes. slov. farm. 2025, 74(4):238-242 | DOI: 10.36290/csf.2025.039

Introduction: Radiopharmaceutical ⁶⁸Ga-PSMA-11 represents gallium-68 radiolabeled peptide, molecular target for prostate-specific membrane antigen (PSMA) in prostate cancer. Objective: The aim of this paper is to describe the experience with this radiopharmaceutical in view of radiopharmaceutical technology of preparation and radiopharmaceutical analysis. Methods: This work studies and evaluates quality parameters of radiopharmaceutical ⁶⁸Ga-PSMA-11. Results: Quality parameters of radiopharmaceutical ⁶⁸Ga-PSMA-11 prepared at our department from kits for radiopharmaceutical and radionuclide generator ⁶⁸Ge/⁶⁸Ga...

The role of the pharmacist in the management of anticoagulant therapy with warfarin - literature reviewReview articles

Stanislav Gregor, Josef Malý

Čes. slov. farm. 2025, 74(4):230-237 | DOI: 10.36290/csf.2025.038

Introduction and aim: Warfarin treatment is associated with the risk of bleeding and thrombotic events. Although it is used less frequently, it still holds an important position in a specific patient population. Therefore, it is necessary to find ways to improve the management of its administration. One option is the implementation of a pharmacist in the anticoagulation team. The aim of the work is to provide a literature review of the role and contribution of the pharmacist in the anticoagulation management of warfarin and the possibilities of pharmacist implementation in the anticoagulation team. Methods: When searching for suitable works, the PubMed...

Treatment of arterial hypertension in children and adolescentsCurrent pharmacotherapy

Eva Klásková, Sabina Kaprálová, Alžběta Palátová, Josef Vičar, Blažena Ševčíková

Čes. slov. farm. 2025, 74(4):222-227 | DOI: 10.36290/csf.2025.035

Arterial hypertension (AH) is a serious health problem that begins in childhood and adolescence and contributes significantly to the early development of ischemic heart disease in adulthood. The prevalence of AH in childhood is approximately 2-5 %. Secondary aetiology of AH is significantly more common in children than in adults. Within paediatric populations, primary AH treatment regimens prioritise non-pharmacological interventions. The selection of an appropriate antihypertensive treatment is dependent on the underlying aetiology of hypertension, whilst also considering the presence of any concomitant comorbidities.

Hearing aids and hearing protectionMedical devices#E-publication

PharmDr. Petra Svačinová, Ph.D., Bc. Vendula Guldánová, doc. PharmDr. Barbora Vraníková, Ph.D.

Čes. slov. farm. 2025, 74(3):E12-E16 | DOI: 10.36290/csf.2025.026

Hearing impairments or hearing loss affect a person's social, professional, and personal activities, and are therefore closely linked to quality of life. The largest group of hearing-impaired patients consists of older adults whose hearing deteriorates with age, but hearing disorders also affect children and people of working age. The use of an appropriate and properly adjusted hearing aid can help improve hearing and speech comprehension in cases of hearing loss. One of the most common causes of hearing loss or damage is exposure to excessive noise. For this reason, it is important to focus on prevention, which includes the use of hearing...

Oral ulceration and stomatitis induced by mycophenolate mofetil in a 4-year-old boy after kidney transplantation – a case reportFor the practice of a clinical pharmacist # E-publication

Nikola Halačová, Miroslava Brndiarová, Jakub Zieg, Júlia Kvaššayová, Alena Szökeová, Miloš Jeseňák

Čes. slov. farm. 2025, 74(3):E8-E11 | DOI: 10.36290/csf.2025.025

Kidney transplantation is currently considered the optimal and effective treatment for pediatric patients with end-stage kidney disease. Immunosuppressive treatment is essential throughout the entire functioning period of the transplanted kidney to prevent graft rejection. Aphthous stomatitis with painful ulcerations is a common complication among kidney transplant recipients. A rare cause of this condition is the adverse effect of mycophenolate mofetil, which is part of the most common stable triple combination of immunosuppressive drugs. This article presents a case of multiple painful oral ulcerations induced by mycophenolate mofetil...

ADME Profile Calculation and Drug Similarity Study of New 1,2,4-Triazole Derivatives Containing 2-Bromo-5-Methoxyphenyl RadicalOriginal articles # E-publication

Mykola Skoryi, Roman Shcherbyna, Sergii Kulish, Volodymyr Salionov, Oleksandra Cherchesova

Čes. slov. farm. 2025, 74(3):E1-E5 | DOI: 10.36290/csf.2025.024

Introduction: Evaluating ADME (absorption, distribution, metabolism, excretion) profiles is critical in drug development to ensure bioavailability, efficacy, and safety. 1,2,4-Triazole derivatives, particularly those with a 2-bromo-5-methoxyphenyl radical, are promising due to their broad biological activities, yet their pharmacokinetic properties are insufficiently studied. The objective of this study was to predict the ADME characteristics and drug-likeness of these compounds to identify candidates with optimal pharmacokinetic potential for therapeutic applications. Objectives: This study aimed to assess the ADME profiles of new 1,2,4-triazole...