Pharmaceutical company Norgine in Ústí nad Labem (Aussig)From the history of pharmacy and healthcare

Tomáš Arndt

Čes. slov. farm. 2024, 73(3):E23-E26 | DOI: 10.36290/csf.2024.034  

Norgine was founded in 1909 and began operations in Ústí nad Labem. Its founder was Doctor of Chemistry Victor Stein. The company originally produced sodium alginate and chemical preparations from imported seaweed (which gave it its name). Her first drugs included the laxative Normacol and the canker sore tincture Pyralvex (both still in production today). After the First World War, the company focused on the group of medicines. The principal part of its portfolio was insulins. The company also collaborated with prominent German pharmacologists from the German University in Prague, first with Professor Wilhelm Wiechowski (1873-1928) and Professor...

Enhancing pharmacovigilance practices: Insights from audits and ethical connotationsOriginal articles # E-publication

Anetta Jedličková

Čes. slov. farm. 2024, 73(3):E13-E22 | DOI: 10.36290/csf.2024.033  

Pharmacovigilance, pivotal in ensuring drug safety and regulatory compliance, requires meticulous surveillance and adherence to ethical standards. This article explores the multifaceted realm of pharmacovigilance, emphasizing the essential role of pharmacovigilance audits and compliance monitoring. By delving into key areas such as drug safety surveillance, signal detection, literature monitoring, and ethical considerations, this research sheds light on critical aspects of pharmacovigilance activities. The paper examines the outcomes of pharmacovigilance audits, highlighting common findings and areas for improvement to enhance regulatory compliance...

Novel pyrazole bearing heterocyclic hybrids as promising biologically active compoundsOriginal articles # E-publication

Kostiantyn Shabelnyk, Yevhen Zaika, Dmytro Skoryna, Inna Nosulenko, Anna Kinichenko, Oleksii Voskoboinik, Serhii Kovalenko

Čes. slov. farm. 2024, 73(3):E7-E12 | DOI: 10.36290/csf.2024.032  

The paper presents the results of a study devoted to the synthesis, evaluation of physicochemical properties, antiradical, and antimicrobial activity of pyrazole-containing heterocyclic hybrids. It has been shown that pyrazole bearing heterocyclic hybrids that contain quinazoline, triazoloquinazoline or triazole moieties are available via a series of reactions that include the interaction of 4-chloroquinazoline with pyrazole-containing hydrazides, cyclization of formed products into corresponding triazoloquinazolines, and hydrolytic cleavage of the electron-deficient tricyclic system. The structures of synthesized compounds have been verified by a...

Evaluation of polycystic ovary syndrome pharmacotherapyOriginal articles # E-publication

Kolesárová Mária, Zálešová Nikola, Marcinčáková Dana, Dalibor Kolesár, Mačeková Zuzana

Čes. slov. farm. 2024, 73(3):E1-E6 | DOI: 10.36290/csf.2024.031  

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects approximately 5-10 % of women of reproductive age. PCOS can have a significant impact on the quality of life of affected women, contributing to fertility problems and increasing the risk of metabolic and cardiovascular diseases. The aim of this study was to compare and evaluate the effectiveness of indicated 6-month pharmacotherapy in patients with PCOS. Data were collected from the medical records of patients in the gynecological outpatient clinic in Stara Lubovna. A total of 980 patients were enrolled in the study, of which 40 (4 %) were diagnosed with PCOS. At the beginning...

30 let Lékového informačního centra FAF UKEditorial

PharmDr. Kateřina Malá-Ládová, Ph.D.

Čes. slov. farm. 2024, 73(3):143  

Přidání extraktu EGb 761 ke kognitivům je účinnější než monoterapieCompany information

MUDr. Andrea Skálová

Čes. slov. farm. 2024, 73(3):199-200  

Available diagnostic tests in the pharmacy and the role of the pharmacistMedical devices

Eliška Kolmanová, Ondřej Tesař

Čes. slov. farm. 2024, 73(3):193-198 | DOI: 10.36290/csf.2024.030  

The topic of in vitro diagnostic tests is a relatively robust area of medical devices. It includes tests used in the providing of healthcare, i.e., intended for healthcare professionals, and a group of tests intended directly for consumers (Direct-To-Consumer tests). The subject of the following article is diagnostic tests intended for home in vitro self-testing of patients in the Czech Republic. The aim is to present a basic overview of the available tests, to present the principle of diagnostic tests and in selected groups of tests to summarise the most important information for the correct performance of tests that should be part of pharmaceutical care.

Pain and possibilities of its self-treatment - what can be recommended in a pharmacy?Self medication

Markéta Pitrová, Anna Koubová

Čes. slov. farm. 2024, 73(3):187-192 | DOI: 10.36290/csf.2024.029  

Pain is one of the most common health problems for which patients seek help in the pharmacy. Pharmacists and pharmaceutical assistants are the most easily approachable healthcare professionals with deep pharmacotherapeutic knowledge and therefore are able to recommend appropriate pain self-medication including non-pharmacological therapy based on evaluation of patient´s problems and other factors. This article summarizes mainly pharmacological pain treatment options with currently available over-the-counter medicines, also some non-pharmacological recommendations and tries to emphasize rational approach in terms of safety of pharmacotherapy (adverse...

1,8-cineole (eucalyptol) in a therapy of respiratory diseasesMedicinal plants and nutraceutics

Zdeňka Navrátilová

Čes. slov. farm. 2024, 73(3):181-186 | DOI: 10.36290/csf.2024.028  

1,8-cineole (eucalyptol) is a natural terpenic compound isolated from eucalyptus essential oil, it is present also in other plant species, especially from Lamiaceae, Myrtaceae, and Zingiberaceae family. Plants containing 1,8-cineole have long been used to treat common cold and other respiratory diseases, gastrointestinal complaints, fever, infections, asthma, rheumatism, and skin conditions. 1,8-cineole is used in foods, cosmetics, perfumery, and also in pharmaceutical industry. 1,8-cineole exerts an antimicrobial, antiviral, mucolytic, anti-inflammatory and bronchodilatory effect and is suitable for the treatment of respiratory infections and other...

Acute intoxications with medications in children and the role of pharmacist in the National toxicological information centerFor the practice of a clinical pharmacist

Erik Puchoň, Blažena Cagáňová, Silvia Plačková

Čes. slov. farm. 2024, 73(3):176-179 | DOI: 10.36290/csf.2024.027  

National Toxicological Information Center (NTIC) provides 24 hours telephone consultation service in acute intoxications for physicians, health care providers and general public. More than half of all consulted intoxications provided by NTIC belong to the group of children younger than 18 years old. Children 3 years old and younger were the main group of consulted intoxications in all children. Intoxications in children with the age up to 5 years old are often accidental intoxications without any or only mild symptoms. Older children and adolescents are more often consulted due to the suicidal attempt with moderate or severe symptoms. Chemicals, medications...

New approaches to the issue of pyrogens in parenteral preparationsPharmaceutical technology

Michal Janů

Čes. slov. farm. 2024, 73(3):169-174 | DOI: 10.36290/csf.2024.026  

The article provides a basic understanding of the pathophysiology of exogenous and endogenous pyrogens, particularly in the context of parenteral administration of drugs and the use of medical devices. It explains that pyrogens cause an increase in body temperature by activating the thermoregulatory center in the hypothalamus, with bacterial lipopolysaccharides being the most common source of pyrogenic burden. Contamination of pharmaceuticals with pyrogenic substances can lead to adverse effects, including life-threatening conditions. The text focuses on modern methods for identifying pyrogens, specifically endotoxins, and selecting suitable analytical...

Omega-3 fatty acids in nutrition and supplementationReview articles

Miloslav Hronek, Miroslav Kovařík

Čes. slov. farm. 2024, 73(3):164-167 | DOI: 10.36290/csf.2024.025  

Omega-3 fatty acids (n-3 PUFAs) have gained significant attention in the field of nutrition and health due to their many positive effects. This article provides a review of n-3 PUFAs, including their definition, classification, structural and functional characteristics, as well as their importance in nutrition and supplementation. In addition, it describes nutritional sources, discusses maximum doses, and describes recommended daily doses.

Current pharmacotherapy of rosaceaCurrent pharmacotherapy

Magdalena Ryšavá, Renata Žáková

Čes. slov. farm. 2024, 73(3):156-162 | DOI: 10.36290/csf.2024.024  

Up to one-fifth of patients in GP surgeries have skin diseases. One of the most serious is rosacea, which can significantly reduce quality of life and increase the incidence of psychosocial disorders (depression, anxiety, social isolation) in patients with this disease. The prevalence of the disease is reported to be around 10 %. Successful dermatological treatment of rosacea is a complex process involving a correct diagnostic assessment, choosing an appropriate therapeutic approach for the patient. It is mainly guided by the severity of symptoms, the psychological impact on the patient and the compliance to treatment. Primarily, provocative factors...

Pharmaceutical care for patients with acneCurrent pharmacotherapy

Tereza Toušková, Kateřina Malá-Ládová

Čes. slov. farm. 2024, 73(3):148-155 | DOI: 10.36290/csf.2024.023  

Acne is a multifactorial inflammatory skin disease affecting mostly adolescents, but it can persist into adulthood. The aim of treatment is to improve the patient's dermatological condition and improve the overall quality of life. Pharmacists play a very important role in the care of acne patients and this article reviews opportunities for pharmaceutical care of such patients. Pharmacists can identify patients with different forms of acne, engage in acne prevention including lifestyle modifications, and contribute to optimizing the choice and use of appropriate pharmacotherapy accompanied by non-pharmacological approaches according to the specific...

The use of certain elements of the marketing communications system by Ukrainian pharmacies in emergenciesOriginal articles # E-publication

Valerii Demchenko, Viktoriia Demchenko, Natalia Tkachenko, Tamara Mahanova

Čes. slov. farm. 2024, 73(2):e21-e27 | DOI: 10.36290/csf.2024.021  

The purpose of the study was to determine the degree of influence of the marketing communications system elements on consumer preferences for pharmaceutical products and the loyalty of drug consumers to pharmacies in the conditions of martial law, with further recommendations for the management of pharmacies in wartime. The results of the study showed that the patient’s choice of a pharmacy to receive pharmaceutical care is largely influenced by the following factors: convenient location of the pharmacy to the place of residence; affordable prices for the necessary medicines and the level of physical availability of medicines that meets all...

Pharmaceutical care of patients with metabolic syndrome in Slovakia - questionnaireOriginal articles # E-publication

Zuzana Mačeková, Michaela Krivošová, Ján Klimas

Čes. slov. farm. 2024, 73(2):e15-e20 | DOI: 10.36290/csf.2024.020  

Introduction: Prevalence of both, metabolic syndrome (MetS) and cognitive impairment, is increasing with age. In general, MetS causes worsening of overall intellectual functioning and, also, a worsened overall health status. In elderly, cognitive impairment predicts increasing risk of drug-related problems, lower abilities of medication self-management and lower adherence. Early management of MetS and its components may also help to control cognitive decline and to identify high-risk individuals for potential mild cognitive impairment earlier. Aim: To assess pharmacists' knowledge of MetS, to assess pharmacists' perceptions of the prevalence of cognitive...

Auxiliary drugs (benzodiazepines, opioid analgesics, presynaptic α2-adrenergic receptor agonists, peripheral myorelaxants) used in general anesthesiaReview articles # E-publication

Ružena Čižmáriková, Ladislav Habala, Jindra Valentová

Čes. slov. farm. 2024, 73(2):e1-e14 | DOI: 10.36290/csf.2024.019  

This review represents a continuation of the already published surveys on substances used in local, general inhalational, and intravenous anesthesia. The administration of a single active substance in these applications is rare, as it is not capable of inducing anesthesia without seriously compromising hemodynamic or respiratory functions, aggravating the operating conditions, or delaying the postoperative recovery. For this reason, other agents (benzodiazepines, opioid analgesics, presynaptic α2-adrenergic receptor agonists and peripheral myorelaxants) are standard components of general anesthesia (in addition to the anesthetic agents listed...

Vývoj nových modelov cenotvorby a systémov úhrad pre nákladovo efektívne a cenovo dostupné zdravotnícke inovácieEditorial

doc. PharmDr. Tomáš Tesař, Ph.D., MPH, MBA, mimoriadny profesor

Čes. slov. farm. 2024, 73(2):75  

Chronické žilní onemocnění - co vše můžeme udělat pro pacienta v lékárně – Zaznělo na 18. kongresu Praktického lékárenství (19.-20. dubna 2024 v Olomouci)Heard at a congress

MUDr. Zuzana Zafarová

Čes. slov. farm. 2024, 73(2):131-134 | DOI: 10.36290/csf.2024.022  

Paratext in Antidotarium Cassoviense (1732)From the history of pharmacy and healthcare

František Šimon

Čes. slov. farm. 2024, 73(2):124-128 | DOI: 10.36290/csf.2024.018  

In 1732, a work known as Antidotarium Cassoviense was published in Košice, which represents the first attempt at a pharmacopoeia in the territory of Hungarian kingdom. It is very brief, with 28 pages in quarto format. The paper deals with the paratext of the Košice Antidotarium. It contains a translation of all its parts from Latin into Slovak as well as a commentary on them. The parts of the paratext are the title page, the preface, the appendix, the approval of the doctors and the colophon. The preface names two reasons for the publication, one, to try to restore the reputation of the city pharmacy, the other, to help the health of the reader, the...

Comprehensive and Rational Approach to PhotoprotectionSelf medication

Kateřina Tenorová, Ruta Masteiková

Čes. slov. farm. 2024, 73(2):118-123 | DOI: 10.36290/csf.2024.017  

Complex and rational photoprotection is a fundamental prerequisite for limiting the harmful effects of UV radiation on the human body. It primarily includes avoiding the sun or eliminating being in the sun, using photoprotective textiles, sunglasses with a UV filter, and sunscreens. Although the focus is primarily on choosing the optimal sunscreen and the UV filters it contains, sufficient and repeated application is essential. This article aims to summarize the abovementioned aspects, highlight the importance of comprehensive measures, and remind readers that even photoprotection must be approached with common sense.

Travellers' diarrhoea - what to advise at a pharmacy currently?Self medication

Markéta Olšovská

Čes. slov. farm. 2024, 73(2):113-117 | DOI: 10.36290/csf.2024.016  

Traveling abroad carries the risk of traveler's diarrhea, which affects 20 to 50% of individuals. This article focuses on the definition, classification, epidemiology, etiology, prevention, and treatment management of traveler's diarrhea. It also describes recommendations for patients traveling to higher-risk areas, which can be used by pharmacists in counceling activities in the pharmacy.

Daprodustat: a new approach to the treatment of anemia in chronic kidney diseaseMedicamenta nova

Viktória Paulusová, Pavel Ryšánek, Martin Šíma, Ondřej Slanař

Čes. slov. farm. 2024, 73(2):110-112 | DOI: 10.36290/csf.2024.013  

Daprodustat, also known under the trade name DUVROQ, is a small molecule developed by GlaxoSmithKline, which has become a promising drug in the field of anemia treatment in patients with chronic kidney disease. Daprodustat belongs to a group of drugs called hypoxia-inducible factor prolyl hydroxylase inhibitors. These drugs interfere with the regulation of erythropoietin, which is a key factor in the production of red blood cells. This drug was approved in Japan in June 2020 and clinical studies with it are ongoing in several countries around the world, where they focus on evaluating the effectiveness and safety in various populations of patients with...

Comprehensive therapy of upper functional dyspepsia: the potential of herbal medicinesMedicinal plants and nutraceutics

Vilma Vranová

Čes. slov. farm. 2024, 73(2):105-109 | DOI: 10.36290/csf.2024.012  

Functional gastrointestinal disorders are among the most common diseases. The treatment of these conditions must be comprehensive. The foundation of therapy includes lifestyle modifications, appropriate dietary adjustments, physiotherapy, and pharmacotherapy. Herbal medicines can also play a significant role in self-treatment.

Drug-related hospitalizations - insights from the Czech RepublicOriginal Articles

Zuzana Juhásová, Martina Maříková, Jiří Vlček

Čes. slov. farm. 2024, 73(2):93-102 | DOI: 10.36290/csf.2024.015  

Background and objective: Drug-related hospitalizations represent a significant burden on healthcare. The aim of the study was to determine the prevalence of drug-related hospitalizations and identify medications and clinical manifestations associated with drug-related hospitalizations in patients admitted to hospital through the emergency department. Methods: This cross-sectional study examined unplanned hospitalizations at the University Hospital Hradec Kralove through the Department of Emergency Medicine between August and November 2018. Data were obtained from electronic health records. The methodology for identifying drug-related hospitalizations...

What should we know about the skin as an application site for (not only) dermo-cosmetic products?Review articles

Andrej Kováčik, Barbora Vraníková, Robert Čáp

Čes. slov. farm. 2024, 73(2):88-92 | DOI: 10.36290/csf.2024.014  

The human skin can undoubtedly be regarded as the largest organ of the human body. This multi-layered selectively permeable tissue protects internal organs and other tissues from damage and is in direct contact with the surrounding environment. Part of this environment includes various substances, medicinal preparations, medical devices, and cosmetics. This article highlights selected facts regarding human skin's structure, significance, and role in local/topical product application. In addition to the overall condition of the skin (healthy vs. diseased), the structure of epidermis/stratum corneum and the pH of the skin surface are key factors influencing...

The importance of neurotropic vitamins in the prevention and adjuvant therapy of peripheral neuropathy - A pharmacist's comprehensive viewCurrent pharmacotherapy

Ondřej Šimandl

Čes. slov. farm. 2024, 73(2):80-87 | DOI: 10.36290/csf.2024.011  

Peripheral neuropathy is one of the most common neurological diseases of the peripheral nervous system. According to current statistics, it affects 2.4% of the Czech population, and its prevalence continues to increase with age. The possibilities of its treatment are to a large extent limited, and its effectiveness and the patient's tolerance of pharmacotherapy are individual. Neurotropic vitamins, which support the function of neurons and contribute to their protection and regeneration, represent a promising possibility for prevention and use in adjuvant therapy for patients suffering from this disease. Despite the fact that the diagnosis and treatment...

Odborné akce pořádané Českou farmaceutickou společnosti České lékařské společnosti J. E. Purkyně, z. s., v roce 2024 Josef MalýNews from Czech Pharmaceutical Society

Josef Malý

Čes. slov. farm. 2024, 73(1):66  

Česká a slovenská farmacie, časopis pro všechny farmaceutyEditorial

Výbor České farmaceutické společnosti

Čes. slov. farm. 2024, 73(1):3  

Rhinitis and Allergic Rhinitis - self-medication optionsSelf medication

Žaneta Tomčalová

Čes. slov. farm. 2024, 73(1):58-65 | DOI: 10.36290/csf.2024.010  

Rhinitis is one of the common diseases that the patient often does not consider necessary to consult a doctor and turns directly to the pharmacist in the pharmacy, who is usually much more accessible to him. It is definitely not appropriate to consider the rhinitis. The pharmacist's role in self-medication therefore consists in trying to determine from the patient's description of his troubles what type of rhinitis it may be, to assess the degree of severity and to decide on the necessity of intervention by a doctor, or the recommendation of a therapeutic procedure with over-the-counter medicinal products. In the case of self-medication, choose the...