Role Subkatedry klinické farmacie v systému specializačního vzdělávání farmaceutů v České republiceEditorial

PharmDr. Martina Maříková, Ph.D.

Čes. slov. farm. 2025, 74(4):219

Topical application of vitamin C and its derivatives in dermatology and cosmeticsSelf medication

Hana Hořavová, Kateřina Brückner

Čes. slov. farm. 2025, 74(4):272-275 | DOI: 10.36290/csf.2025.044

Vitamin C (ascorbic acid) is a highly valued bioactive substance with extensive use in dermatology and cosmetics. Its main effects are strong antioxidant capacity, collagen synthesis boosting, depigmentation effect and improvement of the skin barrier. Due to these properties, it is a popular ingredient in preparations intended for the prevention of aging and correction of photodamage. Despite its biological efficacy, topical use of vitamin C represents a technological challenge due to its low stability and limited ability to penetrate the skin. The work summarizes the key factors influencing its efficacy - including concentration, pH, formulation and...

Self-treatment of cough in respiratory infectionsSelf medication

Hana Kotolová

Čes. slov. farm. 2025, 74(4):264-271 | DOI: 10.36290/csf.2025.043

Cough is one of the most common symptoms with which patients search pharmaceutical care. Most cases have a viral etiology and do not require medical intervention, therefore the pharmacist has a key role in patient education and in recommending appropriate self-treatment. Correct differentiation of the type of cough and selection of appropriate treatment can significantly shorten the duration of the problem and prevent further complications. For dry cough, short-term administration of antitussives is appropriate, while for wet cough, mucolytics or expectorants are recommended. Regimen measures are also an integral part of self-treatment.

Bioactive compounds with adjuvant therapeutic potential in neurodegenerative diseases and peripheral neuropathyPhytotherapy and nutraceuticals

Alice Sychrová

Čes. slov. farm. 2025, 74(4):258-262 | DOI: 10.36290/csf.2025.042

Introduction: Neurodegenerative diseases and peripheral neuropathies share several common pathophysiological mechanisms, including oxidative stress, neuroinflammation, and mitochondrial dysfunction. Although their clinical manifestations differ, similar neuroprotective therapeutic approaches are applied in both conditions. Aim: The aim of this review is to summarize current knowledge on the use of nutraceuticals and vitamin supplementation as adjuvant strategies in the prevention and treatment of neurodegenerative diseases and peripheral neuropathies. Methods: The literature review focused on studies evaluating the efficacy, mechanisms of action,...

Selected case reports from the practice of a clinical pharmacist in the field of pneumologyCase reports from pharmacy practice

Blanka Pelantová, Petra Halvová, Petra Rozsívalová, Lenka Dejdarová, Vladimír Koblížek, Filip Gabalec, Josef Malý

Čes. slov. farm. 2025, 74(4):252-257 | DOI: 10.36290/csf.2025.041

This article presents three case studies highlighting complex pharmacotherapeutic challenges and the role of a clinical pharmacist in clinical practice. The first case describes the long-term treatment of avian mycobacteriosis (MAC - Mycobacterium avium complex) in a patient with cystic fibrosis. It details the patient's history of multi-drug resistant MAC infection, numerous antituberculosis regimens, and significant drug intolerances, emphasizing the need for careful consideration of drug interactions, particularly with cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The second case focuses on the management of a drug...

Choosing wisely in practice: How sick day rules help prevent medication-related complicationsFor the practice of a clinical pharmacist

Petra Rozsívalová, Petra Šubrtová, Karolína Russ, Petr Grenar, Jiří Nový, Dan Rakušan, Jiří Cyrany, Kateřina Langmaierová

Čes. slov. farm. 2025, 74(4):244-251 | DOI: 10.36290/csf.2025.040

Introduction and Aim: Sick Day Rules represent a practical multidisciplinary procedure for temporarily adjusting or suspending certain medications during an acute illness to prevent drug-related complications, especially acute kidney injury. This article aims to introduce the international concept of Sick Day Rules and proposes its application in Czech clinical practice. Methods: Literature search and analysis in the PubMed and Google Scholar databases using keywords focused on Sick Day Rules, prevention of medication-related complications, and medicine re-initiation during acute illness. Resources used included consensus documents, clinical reviews,...

Radiopharmaceutical ⁶⁸Ga-PSMA-11 for prostate cancer diagnosticsPharmaceutical technology

Michal Budinský, Ján Melicherík, Petr Vyšinský

Čes. slov. farm. 2025, 74(4):238-242 | DOI: 10.36290/csf.2025.039

Introduction: Radiopharmaceutical ⁶⁸Ga-PSMA-11 represents gallium-68 radiolabeled peptide, molecular target for prostate-specific membrane antigen (PSMA) in prostate cancer. Objective: The aim of this paper is to describe the experience with this radiopharmaceutical in view of radiopharmaceutical technology of preparation and radiopharmaceutical analysis. Methods: This work studies and evaluates quality parameters of radiopharmaceutical ⁶⁸Ga-PSMA-11. Results: Quality parameters of radiopharmaceutical ⁶⁸Ga-PSMA-11 prepared at our department from kits for radiopharmaceutical and radionuclide generator ⁶⁸Ge/⁶⁸Ga...

The role of the pharmacist in the management of anticoagulant therapy with warfarin - literature reviewReview articles

Stanislav Gregor, Josef Malý

Čes. slov. farm. 2025, 74(4):230-237 | DOI: 10.36290/csf.2025.038

Introduction and aim: Warfarin treatment is associated with the risk of bleeding and thrombotic events. Although it is used less frequently, it still holds an important position in a specific patient population. Therefore, it is necessary to find ways to improve the management of its administration. One option is the implementation of a pharmacist in the anticoagulation team. The aim of the work is to provide a literature review of the role and contribution of the pharmacist in the anticoagulation management of warfarin and the possibilities of pharmacist implementation in the anticoagulation team. Methods: When searching for suitable works, the PubMed...

Treatment of arterial hypertension in children and adolescentsCurrent pharmacotherapy

Eva Klásková, Sabina Kaprálová, Alžběta Palátová, Josef Vičar, Blažena Ševčíková

Čes. slov. farm. 2025, 74(4):222-227 | DOI: 10.36290/csf.2025.035

Arterial hypertension (AH) is a serious health problem that begins in childhood and adolescence and contributes significantly to the early development of ischemic heart disease in adulthood. The prevalence of AH in childhood is approximately 2-5 %. Secondary aetiology of AH is significantly more common in children than in adults. Within paediatric populations, primary AH treatment regimens prioritise non-pharmacological interventions. The selection of an appropriate antihypertensive treatment is dependent on the underlying aetiology of hypertension, whilst also considering the presence of any concomitant comorbidities.

Hearing aids and hearing protectionMedical devices#E-publication

PharmDr. Petra Svačinová, Ph.D., Bc. Vendula Guldánová, doc. PharmDr. Barbora Vraníková, Ph.D.

Čes. slov. farm. 2025, 74(3):E12-E16 | DOI: 10.36290/csf.2025.026  

Hearing impairments or hearing loss affect a person's social, professional, and personal activities, and are therefore closely linked to quality of life. The largest group of hearing-impaired patients consists of older adults whose hearing deteriorates with age, but hearing disorders also affect children and people of working age. The use of an appropriate and properly adjusted hearing aid can help improve hearing and speech comprehension in cases of hearing loss. One of the most common causes of hearing loss or damage is exposure to excessive noise. For this reason, it is important to focus on prevention, which includes the use of hearing...

Oral ulceration and stomatitis induced by mycophenolate mofetil in a 4-year-old boy after kidney transplantation – a case reportFor the practice of a clinical pharmacist # E-publication

Nikola Halačová, Miroslava Brndiarová, Jakub Zieg, Júlia Kvaššayová, Alena Szökeová, Miloš Jeseňák

Čes. slov. farm. 2025, 74(3):E8-E11 | DOI: 10.36290/csf.2025.025  

Kidney transplantation is currently considered the optimal and effective treatment for pediatric patients with end-stage kidney disease. Immunosuppressive treatment is essential throughout the entire functioning period of the transplanted kidney to prevent graft rejection. Aphthous stomatitis with painful ulcerations is a common complication among kidney transplant recipients. A rare cause of this condition is the adverse effect of mycophenolate mofetil, which is part of the most common stable triple combination of immunosuppressive drugs. This article presents a case of multiple painful oral ulcerations induced by mycophenolate mofetil...

ADME Profile Calculation and Drug Similarity Study of New 1,2,4-Triazole Derivatives Containing 2-Bromo-5-Methoxyphenyl RadicalOriginal articles # E-publication

Mykola Skoryi, Roman Shcherbyna, Sergii Kulish, Volodymyr Salionov, Oleksandra Cherchesova

Čes. slov. farm. 2025, 74(3):E1-E5 | DOI: 10.36290/csf.2025.024  

Introduction: Evaluating ADME (absorption, distribution, metabolism, excretion) profiles is critical in drug development to ensure bioavailability, efficacy, and safety. 1,2,4-Triazole derivatives, particularly those with a 2-bromo-5-methoxyphenyl radical, are promising due to their broad biological activities, yet their pharmacokinetic properties are insufficiently studied. The objective of this study was to predict the ADME characteristics and drug-likeness of these compounds to identify candidates with optimal pharmacokinetic potential for therapeutic applications. Objectives: This study aimed to assess the ADME profiles of new 1,2,4-triazole...

Mezinárodní sympozium EFMC o pokrocích v syntetické a medicinální chemiiInformation

prof. PharmDr. Martin Doležal, Ph.D.

Čes. slov. farm. 2025, 74(3):210  

Specializační vzdělávání farmaceutů v gesci katedry lékárenství: Klíč k profesnímu růstu a kvalitní farmaceutické péčiEditorial

PharmDr. Marcela Heislerová, Ph.D.

Čes. slov. farm. 2025, 74(3):147  

Self-treatment for dry eye syndromeSelf medication

Tereza Korejsová, Iva Klicmanová, Dana Liláková

Čes. slov. farm. 2025, 74(3):199-207 | DOI: 10.36290/csf.2025.034  

Dry eye syndrome is the most common cause that leads a patient to seek quick relief from symptoms in a pharmacy. The aim of the article is to define dry eye syndrome, distinguish it from other eye diseases and provide guidance in choosing appropriate products or over-the-counter remedies. As part of comprehensive care for a patient with dry eye syndrome in a pharmacy, an overview of nutritional and dietary measures that can be offered by a pharmacist and a pharmaceutical assistant is also provided.

Periodontitis: pharmacist's options in its prevention and treatmentSelf medication

Lucie Hromčík Brunclíková

Čes. slov. farm. 2025, 74(3):194-198 | DOI: 10.36290/csf.2025.033  

Periodontitis is the most common non-communicable inflammatory disease of humans. Although it affects the periodontal apparatus, its prevention and treatment are not solely the responsibility of the dentist and the dental hygienist. The pharmacist, as part of a multidisciplinary team, plays a role in supporting the patient's dental health and in identifying and educating at-risk patients. Increasing pharmacists' competence in the care of patients with periodontitis could lead to a reduction in its incidence and more effective treatment.

Interesting pharmacological effects of phenolic acids found in plantsMedicinal plants and nutraceutics

Jana Karlíčková, Lucie Klížová

Čes. slov. farm. 2025, 74(3):188-192 | DOI: 10.36290/csf.2025.032  

Fenolic acids are present in plants as secondary metabolites and are a common part of the human diet. This is beneficial for the consumer, as their antioxidant activity is known to reduce the risk of neurodegenerative, cardiovascular and oncological diseases. This activity is related to the ability to scavenge free radicals and depends on their structure, especially on the number and positions of hydroxyl groups, as well as the character of substitutions on aromatic rings. Their other significant effects are antiviral, antibacterial, anti-inflammatory and antifungal. Due to the complex of many beneficial effects, they are investigated in more detail...

Case reports from individual consultations provided to patients in the pharmacyCase reports from pharmacy practice

Eliška Kolmanová, Josef Malý

Čes. slov. farm. 2025, 74(3):182-187 | DOI: 10.36290/csf.2025.031  

The focus of pharmaceutical care is to optimise the patient's pharmacotherapy, aiming to maximise the effects and minimise the risks of treatment. In the pharmacy, the current legislation allows the pharmacist to carry out this activity not only in the context of dispensing activities, but also during the provision of individual counselling. This area of 'modern pharmaceutical care' is a more individualised form of expert advice, ideally carried out in a separate consulting room of the pharmacy through a structured conversation with a trained pharmacist. In addition to the management of drug-related problems in optimising pharmacotherapy, pharmacists...

Resources and drug information on pharmacotherapy in breastfeedingFor the practice of a clinical pharmacist

Kateřina Malá-Ládová, Eliška Rožníčková, Petra Rozsívalová

Čes. slov. farm. 2025, 74(3):172-178 | DOI: 10.36290/csf.2025.030  

Breastfeeding is the optimal method of infant nutrition in early life, supporting physical health, reinforcing maternal-infant bonding, and offering economic and ecological benefits. The aim of this article is a narrative review of available professional information sources utilized by pharmacists, paediatricians, and other healthcare providers in breastfeeding pharmacotherapy decision-making. These include primary evidence (e.g., case reports, clinical lactation studies, adverse drug events reporting systems), secondary systematic reviews and meta-analyses, and tertiary sources comprising authoritative monographs (e.g., Hale's Medications & Mothers'...

Individually prepared medicinal products in palliative carePharmaceutical technology

Lukáš Láznička, Anna Králová

Čes. slov. farm. 2025, 74(3):166-170 | DOI: 10.36290/csf.2025.029  

Individually prepared medicinal products represent one of the forms of personalisation of pharmacotherapy in palliative care. We use the full range of individually prepared medicinal products for symptom management and rational supportive care, especially in situations where a medicinal product with appropriate therapeutic properties is not available for the patient.

Current trends in the teatment of multiple sclerosisCurrent pharmacotherapy

Jana Libertínová

Čes. slov. farm. 2025, 74(3):158-163 | DOI: 10.36290/csf.2025.028  

Multiple sclerosis is a chronic disease of the central nervous system, in the pathogenesis of which both autoimmune inflammation and neurodegeneration play a role. It is a serious disease diagnosed most often in young adulthood and, without treatment, is the most common cause of non-traumatic disability at this age. Therapy, which is currently available immediately after diagnosis, leads to a significant improvement in the prognosis and quality of life of patients.

Medications with dependence potential: Pharmacological aspects and clinical practiseCurrent pharmacotherapy

Ivana Tašková

Čes. slov. farm. 2025, 74(3):152-156 | DOI: 10.36290/csf.2025.027  

The abuse of medications represents a serious and ongoing public health concern. It has extensive consequences for individuals in the form of deteriorating physical and mental health, while also imposing a significant socioeconomic burden on society. This article focuses on the pharmacological aspects of medications associated with the development of substance dependence, with particular emphasis on sedatives, hypnotics, opioid analgesics, stimulants, gabapentinoids, and selected over-the-counter preparations. The development of dependence results from a complex interaction of various risk factors and is primarily influenced by the pharmacokinetic...

The management of vulvovaginal candidiasis: the results of survey in Lviv, UkraineOriginal articles # E-publication

Oksana Horodnycha, Tetiana Ryvak, Oksana Nepyivoda

Čes. slov. farm. 2025, 74(2):E10-E15 | DOI: 10.36290/csf.2025.022  

Vulvovaginal candidiasis (VVC) is a serious clinical and social issue. The questionnaire-based study was performed to assess the management of VVC in Lviv, Ukraine. Totally 408 women were enrolled in the survey. The lifetime prevalence of VVC was high (72.6 %). 35.8 % of women had VVC during the last year with the predominance of 1 episode (72.6 %). The most common symptoms were vaginal itching and cottage cheese-like vaginal discharge, affecting 89.7 % and 71.7 % of women with VVC, respectively. Stress (57.2 %) was the main self-reported factor associated with the VVC, followed by antibiotic therapy (49.7 %)....

Anticonvulsant biotargets of digoxin: in silico study and in vivo verificationOriginal articles # E-publication

Vadym Tsyvunin, Hanna Severina, Sergii Shtrygol’, Victoriya Georgiyants, Diana Shtrygol’

Čes. slov. farm. 2025, 74(2):E1-E8 | DOI: 10.36290/csf.2025.021  

One of the promising ways to control multidrug-resistant epilepsy may be to use, in addition to traditional antiepileptic drugs (AEDs), medicines from other pharmacological groups – the so-called „non-antiepileptic” drugs. Among such drugs, the cardiac glycoside digoxin deserves special attention. It was established that sub-cardiotonic doses of digoxin exhibit both their own anticonvulsant effect and have been shown to enhance the anticonvulsant potential of classical AEDs. However, the mechanisms of this action and the probable cerebral biotargets with which these properties of digoxin may be associated, remain completely unknown....

Doktorské studium na Farmaceutické fakultě UK v Hradci Králové: cesta k vědě, která má smyslEditorial

prof. PharmDr. František Štaud, Ph.D.

Čes. slov. farm. 2025, 74(2):79  

Cestovatelský průjem - příčiny, léčba a prevenceCompany information

Marcela Stibůrková

Čes. slov. farm. 2025, 74(2):136-138  

PhotoprotectionSelf medication

Zuzana Hajšelová

Čes. slov. farm. 2025, 74(2):133-135 | DOI: 10.36290/csf.2025.019  

A significant factor for skin cancer development and premature aging of the skin is undesirable effect of the ultraviolet (UV) radiation. Therefore, appropriate sunprotection method is important. The highest endogenic risk factors are in people with phototype I and II.

Repellents and protection against insects and ticksSelf medication

Irena Bumbalíková

Čes. slov. farm. 2025, 74(2):126-132 | DOI: 10.36290/csf.2025.018  

Mosquitoes, ticks and various other types of annoying insects are often carriers of serious and life-threatening diseases, for this reason it is advisable to protect yourself against them. Repellents are an effective protection. The aim of this article is to introduce you to the substances most often used in repellents, to warn you about their correct use and to create an overview of the preparations used in the Czech Republic. Repellents containing DEET, icaridin, IR3535 and citridiol are, when used correctly, effective and safe means of protection against insects.

Self-treatment options for gynecological issuesSelf medication

Nina Netíková, Táňa Ryantová

Čes. slov. farm. 2025, 74(2):117-125 | DOI: 10.36290/csf.2025.017  

Gynecological issues such as itching, discharge, burning, or dryness are common reasons for seeking medical attention. However, with the wide availability of over-the-counter medications, self-treatment is becoming increasingly relevant. This review article summarizes the most frequent vaginal complaints - vaginal candidiasis, bacterial vaginosis, aerobic vaginitis, mucosal dryness, and genital herpes - and outlines treatment options available within the scope of pharmaceutical care. It highlights the pharmacist's role in educating patients, recommending appropriate therapies, and identifying cases that require medical evaluation. The text also includes...

Good storage practices for medical devices and in vitro diagnostic medical devices by healthcare providersSocial pharmacy

Pavla Justová

Čes. slov. farm. 2025, 74(2):114-116 | DOI: 10.36290/csf.2025.016  

To maintain the quality of medical devices and in vitro diagnostic medical devices used in the provision of healthcare, one of the important factors is also the fulfillment of the conditions for their storage set by the manufacturer. Healthcare providers are required to adhere to good storage practices, which are controlled by the State Institute for Drug Control. The aim of this article is to familiarize themselves with the requirements of good storage practices, which are required and controlled by the regulatory authority.