Resources and drug information on pharmacotherapy in pregnancyFor the practice of a clinical pharmacist

Kateřina Malá-Ládová, Eliška Rožníčková, Petra Rozsívalová

Čes. slov. farm. 2025, 74(2):108-113 | DOI: 10.36290/csf.2025.015  

Pregnancy is a unique period requiring careful assessment of safety and effectiveness of pharmacotherapeutic interventions regarding the mother and foetus. The main source of information on the choice of a drug in pregnancy is usually the summary of product information, which often offers only brief general information and encourages excessive caution. The aim of this article is therefore a narrative overview of available professional information resources on medication use during pregnancy, which can be utilized in the care of pregnant women taking medicines. It demonstrates national and international monographs, biomedical databases, clinical guidelines,...

CAR-T therapy - the role of the pharmacistHospital Pharmacy

Marcela Heislerová

Čes. slov. farm. 2025, 74(2):103-107 | DOI: 10.36290/csf.2025.014  

CAR-T therapy uses and advances the ability of the human immune system to attack tumor cells. It can currently only be administered in specialized treatment centers in the Czech Republic, which must be able to ensure the collection of T lymphocytes, their sending for preparation, the subsequent administration of CAR-T preparations, as well as the recognition, monitoring and management of possible adverse effects of the treatment (1). The aim of this article is to highlight the role of hospital pharmacists, who are key to the correct handling of these highly specialized preparations. Due to the difficulty of handling and the high price of these preparations,...

Proposal of limit values for surface contamination by cytotoxic drugs in pharmacies and hospitalsOriginal Articles

Lenka Doležalová, Lucie Bláhová, Jan Kuta, Tereza Hojdarová, Luděk Bláha

Čes. slov. farm. 2025, 74(2):96-102 | DOI: 10.36290/csf.2025.013  

Introduction: Cytotoxic drugs (cytostatics), widely used in the treatment of not only cancer diseases, are substances with potentially dangerous properties for healthcare personnel. Long-term daily exposure to cytostatics is associated with the possible manifestation of their genotoxic, carcinogenic and teratogenic effects. Handling of these drugs (during receipt, storage, preparation, packaging, transport, administration) can lead to contamination of the workplace and thus to exposure of healthcare personnel present. Objective: The aim of our work was to propose, based on previous results and experience gained from long-term monitoring, a limit threshold...

Current pharmacotheraupeutical options of lower urinary tract symptomsCurrent pharmacotherapy

Marcela Fontana

Čes. slov. farm. 2025, 74(2):90-93 | DOI: 10.36290/csf.2025.012  

Lower urinary tract symptoms (LUTS) represent a wide unit with multifactorial etiology, and therefore, treatment is not uniform. In most patients with LUTS, pharmacotherapy is an effective option for managing these symptoms, thereby improving the quality of life. We have medications from various drug classes available, which can be effectively combined to achieve the best therapeutic outcome. The following text provides an overview of the current pharmacotherapy for LUTS.nce-based medicine principles are essential when searching for and critically evaluating information use in pregnancy.

Current trends in insulin therapyCurrent pharmacotherapy

Kateřina Štechová

Čes. slov. farm. 2025, 74(2):84-89 | DOI: 10.36290/csf.2025.011  

In January 2025, 103 years have passed since the injection of insulin saved the life of the first patient with type 1 diabetes mellitus. The aim of the article is to familiarize readers with current insulin therapy, which is an essential treatment modality for patients with type 1 diabetes, but also for many patients with other types of diabetes mellitus. The current treatment of patients with type 1 diabetes consists of using 2^nd generation insulin analogues, either rapid in insulin pumps, which now also have the so-called hybrid closed-loop function, or patients apply a rapid analogue in combination with a basal analogue by insulin pens....

Covalent drugsReview articles # E-publication

PharmDr. Marta Kučerová, Ph.D.

Čes. slov. farm. 2025, 74(1):E11-E16 | DOI: 10.36290/csf.2025.001  

Covalent drugs are substances capable of forming a reversible or an irreversible covalent bond with a macromolecular target in the body. Despite the risk of adverse reactions in the organism, the design of such agents has become a trend over the last two decades. Drugs acting by covalent mechanisms from different indication groups are summarized in this article and possibly supported with a reference to the crystallographic structure in the Protein Data Bank. The advantages and the disadvantages of using covalent drugs are also discussed.

Adherence to the Pharmacist’s Protocol of sore throat symptomatic treatment in Ukraine and problems of harmonization with international guidelinesOriginal articles # E-publication

Viktoriia Propisnova, Svitlana Misiurova

Čes. slov. farm. 2025, 74(1):E1-E10 | DOI: 10.36290/csf.2025.002  

Background: Good pharmaceutical counselling in the sore throat symptomatic treatment is an important component of the health care first line, timely detection of infectious diseases, provision of qualified assistance, prevention of complications, and correct use of medications. Methods: The study included a self-assessment of adherence of Ukrainian pharmacists to the Pharmacist Protocol through a survey, evaluation of the level of awareness of Ukrainian pharmacists with international standards for the symptomatic treatment of sore throat, assessing prospects and finding ways to harmonize the Ukrainian standard with international ones....

Management of gastrointestinal adverse effects of cancer treatment part 2: Nausea, vomiting, immune-related gastrointestinal adverse effectsCurrent pharmacotherapy

doc. PharmDr. Jan Juřica, Ph.D., PharmDr. Miroslav Turjap, Ph.D.

Čes. slov. farm. 2025, 74(1):8-13 | DOI: 10.36290/csf.2025.003  

Gastrointestinal adverse effects are common in patients with cancer and can be exacerbated by the disease itself. These adverse effects lead to decreased quality of life and may result in discontinuation of therapy and worsening of treatment outcomes. In extreme cases, adverse effects may even result in patient death. Oncology therapy has undergone significant changes in recent decades, introducing a range of new treatments. Unfortunately, these advancements have also brought about a previously unseen spectrum of adverse effects. The first separate part of this article was devoted to diarrhoea, constipation, mucositis and anorexia. This...

Doktorské studium na FaF MU v BrněEditorial

doc. Ing. Pavel Bobáľ, CSc.

Čes. slov. farm. 2025, 74(1):3  

Zaznělo na webináři: Trochu jiný pohled na respirační infekce aneb rozpustit hlen nestačíCompany information

MUDr. Andrea Skálová

Čes. slov. farm. 2025, 74(1):65-68  

Střípky z XXVI. sympozia klinické farmacie René MachaNews from Czech Pharmaceutical Society

Šárka Bělochová, Gabriela Strnadová, Zuzana Juhásová

Čes. slov. farm. 2025, 74(1):58-64 | DOI: 10.36290/csf.2025.009  

Chronic venous disease - what to advice at the pharmacy?Self medication

Klára Kotyková

Čes. slov. farm. 2025, 74(1):51-57 | DOI: 10.36290/csf.2025.008  

In practice, it is quite common to encounter patients who come to the pharmacy because of problems associated with chronic venous disease. They complain, for example, of a feeling of heavy legs, tingling, pain or swelling of the lower limbs. Chronic venous disease is often underestimated, even though it can significantly reduce the quality of life and bring other complications. It is therefore important to start treatment as early as possible, as early-stage therapy tends to be more effective and cost-effective compared to more advanced conditions. Considering that the severity of symptoms does not always correlate with the degree of venous system...

Acute diarrhoea - self-treatment optionsSelf medication

Martin Doseděl, Tereza Hendrychová, Josef Malý

Čes. slov. farm. 2025, 74(1):43-49 | DOI: 10.36290/csf.2025.007  

Diarrhea is a common symptom that is suitable for self-treatment in a significant proportion of patients. The aim of this article was to summarize current knowledge and therapeutic options regarding the management of diarrhea in the context of self-treatment, with emphasis on the active role of the pharmacist or pharmaceutical assistant. To maximize the effect, the most appropriate therapeutic alternative should be recommended to the patient depending on the characteristics of the diarrhea and taking into account the patient's specificities and preferences, while focusing on the appropriate dosage, frequency and route of administration of the product....

A patient with allergy symptoms and options of self-medicationSelf medication

Zuzana Hajšelová

Čes. slov. farm. 2025, 74(1):37-42 | DOI: 10.36290/csf.2025.006  

With the rising prevalence of allergic diseases also rises a demand for safe and effective options for self-medication. The main aim of this article is focused on various types of self-medication using over-the counter preparations and distinguishing the warning signals. Over-the-countermedications contain antihistaminics for local or systemic application and glucocorticoids for local application. Self-medications suitable for short-term management of less severe accute symptoms of allergies.

Self-treatment of acute cough in adults and adolescents older than 12 yearsSelf medication

Lenka Ťupová, Tereza Hendrychová, Josef Malý

Čes. slov. farm. 2025, 74(1):24-36 | DOI: 10.36290/csf.2025.005  

Acute cough is a frequent symptom accompanying upper respiratory tract infections and acute bronchitis. In order to start self-treatment, a thorough consideration of its suitability is necessary. A systematic algorithm can help pharmacists to do this, and its subconscious automation will help them reliably detect warning signs (red flags) of an acute illness or the inappropriateness of self-treatment in risk groups of patients. The presentation of the practical application of the cough self-treatment algorithm is therefore the main goal of this publication. Although a number of over-the-counter products are available for the symptomatic treatment of...

Possibilities of mixing powder mixtures for capsules using three-dimensional mixer devices in pharmacy practicePharmaceutical technology

Ondřej Černý

Čes. slov. farm. 2025, 74(1):16-22 | DOI: 10.36290/csf.2025.004  

Preparing oral powders for filling of hard capsules is one of the basic activities in pharmacies. One of the key operations that affects the resulting homogeneity of the substances in the mixture is the mixing process. Until recently, most pharmacies have used only a porcelain mortar and pestle for the mixing process, where the homogeneity of the resulting mixture is highly dependent on the experience and thoroughness of the preparing pharmacist or pharmacy assistant. In recent years, compact mixing devices that can be used in the pharmacy environment have become more widely employed. One of them is the FagronLab™ InvoMatic three-dimensional...

Pharmaceutical literature in the Broumov Benedictine convent library in the year 1801From the history of pharmacy and healthcare # E-publication

Barbora Machová

Čes. slov. farm. 2024, 73(4):E34-E38 | DOI: 10.36290/csf.2024.038  

The article describes composition of the medical collection in the Broumov Benedictine convent library based on a catalogue from the year 1801, with detailed description of titles on pharmacy and botanics. This is followed by comparison with contemporary content of the "Medici" library department, identification of previous book owners and users based on records on preserved books, and an attempt to find out how the monastery communicated with its secular surroundings in the field of pharmacy.

Evaluation tools used for assessing inhalation technique in patients with chronic obstructive lung disease - a literature reviewReview articles # E-publication

Gabriela Strnadová, Tereza Hendrychová, Vladimír Koblížek, Vratislav Sedlák, Josef Malý

Čes. slov. farm. 2024, 73(4):E9-E33 | DOI: 10.36290/csf.2024.037  

Introduction and aim: Chronic obstructive lung diseases, including bronchial asthma and chronic obstructive pulmonary disease, among others, are characterized by inadequate adherence to inhalation technique. Evaluation of inhalation technique and subsequent repeated patient's education should be a routine part of therapy management. The aim of this article was to provide an overview of tools used to assess inhalation technique in patients with chronic obstructive lung disease based on a literature search and to analyse in more detail individual questionnaires/checklists specific for a group of inhalers or for a particular type of inhaler. Methods:...

Rising consumption of anticoagulants in Central and Eastern European countries in the period 2007–2019Original articles # E-publication

Kateřina Malá-Ládová, Helena Šťastná Koblihová, Eva Zimčíková, Anna Oleárová, Ria Benko, Maria Matuz, Reka Viola, Katarina Gvozdanovic, Pero Draganic, Irina Iaru, Josef Malý

Čes. slov. farm. 2024, 73(4):E1-E8 | DOI: 10.36290/csf.2024.036  

Introduction and Aim: Due to the growing incidence of thromboembolic disease and atrial fibrillation, increasing trends in anticoagulants consumption can be expected. The aim of this study was to analyse the consumption of anticoagulants in the Czech Republic, Croatia, Hungary, Romania, and Slovakia between 2007 and 2019. Methods: A retrospective analysis of anticoagulants comprising B01AA, B01AB, B01AE, B01AF and B01AX was performed using ATC/DDD methodology. The analysis was initiated in the year before the launch of the first non-vitamin K oral anticoagulant (NOAC). The consumption of each drug was assessed based on annual data and was expressed...

XXVIII. mezinárodní sympozium o medicinální chemii se letos konalo v Římě; 52. mezinárodní konference Syntéza a analýza léčiv se vydařilaNews from Czech Pharmaceutical Society

prof. PharmDr. Martin Doležal, Ph.D.

Čes. slov. farm. 2024, 73(4):265  

K 55. výročí založení Farmaceutické fakulty UK v Hradci KrálovéEditorial

doc. PharmDr. Jaroslav Roh, Ph.D.

Čes. slov. farm. 2024, 73(4):211  

Význam vitaminu C v prevenci poruch nervového a imunitního systémuCompany information

Pavel Kostiuk, Lucie Kotlářová, Zdeněk Procházka

Čes. slov. farm. 2024, 73(4):271-275  

Objev nových účinných látek v extraktech z Ginkgo biloba?Company information

MUDr. Andrea Skálová

Čes. slov. farm. 2024, 73(4):268-270  

Medical devices in wound healing V: Special types of wound plasters IIMedical devices

Barbora Vraníková, Andrej Kováčik

Čes. slov. farm. 2024, 73(4):261-264 | DOI: 10.36290/csf.2024.045  

Patches represent a broad category of medical devices with versatile applications that go far beyond their traditional function as wound dressings. This article focuses on the other possible utilization of patches, such as fixation patches for cannulas, patches for epicutaneous tests, warming and cooling patches, patches for acne, anti-snoring patches, and mosquito-repellent patches. In addition to their specific functions, the article highlights the importance of correct application, which represents crucial knowledge not only for pharmacists and pharmacy assistants but also for other healthcare professionals who work with these patches in practice.

Pharmaceutical care for patients with sore throat not requiring medical attentionSelf medication

Lenka Ťupová, Tereza Hendrychová, Josef Malý

Čes. slov. farm. 2024, 73(4):252-260 | DOI: 10.36290/csf.2024.044  

Counsultancy in self-treatment of mild health problems is one of the dominant aspects of providing pharmaceutical care, especially in pharmacy practice. A sore throat is one of the most common reasons for visiting a pharmacy. According to current knowledge, the biggest pitfall of sore throat management is the systematic and reliable classification of patients into uncomplicated and potentially complicated cases, which should ideally take place at the level of pre-medical care, i.e. in a pharmacy. For this purpose, the practical use of the self-treatment algorithm in the therapy of sore throat was presented in the article. The introduction of a systematic...

Adjunctive treatment of behavioral disorders in patients with cognitive deficitFor the practice of a clinical pharmacist

Ivana Tašková

Čes. slov. farm. 2024, 73(4):245-250 | DOI: 10.36290/csf.2024.043  

The article provides an overview of the pharmacotherapy of behavioural and psychological symptoms of dementia (BPSD) in the context of evidence-based medicine. Its goal is to provide readers with a practical and educational overview of managing these symptoms. Cognitive disorders, including dementia, result from the disruption of higher cortical functions of the brain. Dementia often manifests not only through cognitive dysfunction but also through BPSD, such as agitation, aggression, anxiety, psychosis, and sleep disturbances. These symptoms affect up to 97% of patients with dementia and significantly reduce the quality of life for both patients and...

Evaluation tools used for assessing inhalation technique in patients with chronic obstructive lung disease - a literature reviewReview articles

Gabriela Strnadová, Tereza Hendrychová, Vladimír Koblížek, Vratislav Sedlák, Josef Malý

Čes. slov. farm. 2024, 73(4):234-244 | DOI: 10.36290/csf.2024.042  

Introduction and aim: Chronic obstructive lung diseases, including bronchial asthma and chronic obstructive pulmonary disease, among others, are characterized by inadequate adherence to inhalation technique. Evaluation of inhalation technique and subsequent repeated patient's education should be a routine part of therapy management. The aim of this article was to provide an overview of tools used to assess inhalation technique in patients with chronic obstructive lung disease based on a literature search and to analyse in more detail individual questionnaires/checklists specific for a group of inhalers or for a particular type of inhaler. Methods:...

Contamination of drugs with nitrosamines, a restored problemCurrent pharmacotherapy

Martin Doležal, Petr Kastner

Čes. slov. farm. 2024, 73(4):228-232 | DOI: 10.36290/csf.2024.041  

This review article deals with the issue of nitrosamines as impurities in pharmaceuticals. Medicinal products contaminated with nitrosamine raise legitimate concerns about the safety of medicinal use. Nitrosamines are known to be carcinogens and mutagens. This applies not only to valsartan and all tetrazole-containing angiotensin II receptor blockers, but also to ranitidine, nizatidine, pioglitazone, metformin, rifampicin, rifabutin, varenicline and other drugs, some of which have already been withdrawn from clinical practice. The detection of impurities above the limit in pharmaceutical substances then leads to interruptions in production and shortages...

Management of gastrointestinal side effects of cancer pharmacotherapy: Part 1: Diarrhoea, constipation, mucositis and anorexiaCurrent pharmacotherapy

Jan Juřica, Miroslav Turjap

Čes. slov. farm. 2024, 73(4):222-227 | DOI: 10.36290/csf.2024.040  

Gastrointestinal side effects are common in cancer pharmacotherapy and may be facilitated by the disease itself. These adverse effects lead to reduced quality of life and may result in premature termination of therapy, which can adversely affect treatment outcomes. In extreme cases, adverse effects can even lead to patient death. This article reviews the main gastrointestinal side effects of anticancer drug therapy anticancer drug therapy in the context of solid tumor treatment and discusses the appropriate management and discusses the appropriate management of these complications. In the first part of this two-part article, we discuss diarrhoea, constipation,...

Pharmacotherapy of chronic heart failure - essential summary for pharmacistsCurrent pharmacotherapy

Zdeněk Monhart

Čes. slov. farm. 2024, 73(4):216-221 | DOI: 10.36290/csf.2024.039  

Heart failure is a severe and life-threatening condition with significant morbidity and mortality, a reduction in functional capacity and quality of life, and, importantly, heart failure is a substantial social and economic burden. The latest significant advances in therapy have established the recommended pharmacotherapy for patients with heart failure with reduced left ventricular systolic function with fourkey medication classes in each patient: renin-angiotensin-aldosterone system inhibitors (ACE inhibitors, sartans, or sacubitril/valsartan), SGLT2 inhibitors (gliflozins), beta-blockers, and mineralocorticoid receptor antagonists, with diuretics...