JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2026, 75(2):92-98 | DOI: 10.36290/csf.2026.017

Neuropsychiatric symptoms of chronic stress and pharmacist counseling

Daniela Mináriková1, Hana Kotolová2, Milan Grofik3, Jozef Dragašek4, Ján Grossmann5
1 Katedra organizácie a riadenia farmácie, Farmaceutická fakulta, Univerzita Komenského v Bratislave
2 Ústav farmakologie a toxikologie, Farmaceutická fakulta, Masarykova univerzita Brno
3 Neurologická klinika, Jesseniova lekárska fakulta v Martine, Univerzita Komenského v Bratislave, Univerzitná nemocnica Martin
4 I. psychiatrická klinika, Lekárska fakulta Univerzity Pavla Jozefa Šafárika v Košiciach, Univerzitná nemocnica L. Pasteura Košice
5 Psychologická ambulancia, Neurologická klinika, Jesseniova lekárska fakulta v Martine, Univerzita Komenského v Bratislave, Univerzitná nemocnica Martin

Chronic stress negatively affects both mental and physical health. The most common manifestations are neuropsychiatric disorders, which can be characterized by their symptoms and assessed using the proposed "6N" concept. The growing prevalence of these disorders increases the need to address them in pharmacies as well. An effective and safe self-treatment for the neuropsychiatric symptoms of chronic stress involves treating magnesium deficiency with over-the-counter magnesium-containing medications as an etiopathogenetically oriented approach, given the vicious cycle of stress and magnesium, as well as symptomatic treatment of the main symptoms using registered phytopharmaceuticals. In this article, we present the results of a survey and provide explanations and recommendations for the pharmacist's practical approach in real-world pharmacy practice.

Keywords: stress, neuropsychiatric symptoms, magnesium, phytopharmaceuticals, pharmacy.

Accepted: May 27, 2026; Published: June 10, 2026  Show citation

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Mináriková D, Kotolová H, Grofik M, Dragašek J, Grossmann J. Neuropsychiatric symptoms of chronic stress and pharmacist counseling. Čes. slov. farm. 2026;75(2):92-98. doi: 10.36290/csf.2026.017.
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References

  1. Herman JP, Nawreen N, Smail MA, Cotella EM. Brain mechanisms of HPA axis regulation: neurocircuitry and feedback in context Richard Kvetnansky lecture. Stress. 2020;23(6):617-632. doi:10.1080/10253890.2020.1859475. Go to original source... Go to PubMed...
  2. Prokopová B, Ježová D. Stres a možnosti jeho farmakologického ovplyvnenia - vieme merať stresovú záťaž? Psychiatr. praxi. 2013;14(4):150-154.
  3. Grofik M, Mináriková D. Magnézium a stres. Súč Klin Pr. 2024;1:17-24.
  4. Pickering G, Mazur A, Trousselard M, et al. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients 2020; 12(12): 3672. doi: 10.3390/nu12123672 Go to original source... Go to PubMed...
  5. Dragášek J. Magnézium v psychiatrii. In: Grofik M, Cibulka M, Mináriková D, editors. Magnézium - funkcie a homeostáza, klinická medicína, farmakoterapia. Bratislava: Raabe 2024. p. 171-175.
  6. Grofik M. Magnézium v neurológii. In: Grofik M, Cibulka M, Mináriková D, editors. Magnézium - funkcie a homeostáza, klinická medicína, farmakoterapia. Bratislava: Raabe 2024. p. 111-124.
  7. Jezova D, Herman J. P. Stress and stressrelated disease states as topics of multi-approach research, Stress, 2020; 23(6): 615-616, doi:10.1080/10253890.2020.1853400. Go to original source... Go to PubMed...
  8. Východiskový stav duševného zdravia na Slovensku. Project Health Care. [Internet]. Liga za duševné zdravie 2024 [cited 2024 December 5]. Available from: https://dusevnezdravie.sk/unikatna-studia-o-stave-dusevneho-zdravia-na-slovensku-oktober-2023/.
  9. Fan Y, Fan A, Yang Z, Fan D. Global burden of mental disorders in 204 countries and territories, 1990-2021: results from the global burden of disease study 2021. BMC Psychiatry. 2025;25(1):486. doi: 10.1186/s12888-025-06932-y. Go to original source...
  10. Mental health care: A handbook for pharmacists. [Internet]. International Pharmaceutical Federation 2022 [cited 2025 Janury 11]. Available from: https://www.fip.org/file/5212.
  11. Mináriková D, Grofik M, Dragášek J, et al. Stresom podmienené neuropsychiatrické poruchy v lekárni. Súč Klin Pr. 2025;1:5-14.
  12. Mináriková D. Magnézium - farmakoterapia. In: Grofik M, Cibulka M, Mináriková D, editors. Magnézium - funkcie a homeostáza, klinická medicína, farmakoterapia. Bratislava: Raabe 2024. p. 194-220.
  13. Databáze léků 2026. [Internet]. Státní ústav pro kontrolu léčiv 2026 [cited 2026 February 2]. Available from: https://prehledy.sukl.cz/prehled_leciv.html#/.
  14. Nařízení Komise (EU) č. 432/2012 ze dne 16. května 2012, kterým se zřizuje seznam schválených zdravotních tvrzení při označování potravin jiných než tvrzení o snížení rizika onemocnění a o vývoji a zdraví dětí.. [Internet]. Zákony pro lidi [cited 2026 February 2]. Available from: https://www.zakonyprolidi.cz/pravoeu/dokument?celex=32012R0432.




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