JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2026, 75(1):E8-E11 | DOI: 10.36290/csf.2026.002

Skin hydration: How to increase the water content in the skin with dermocosmetics?

Andrej Kováčik1, Barbora Vraníková1, Robert Čáp2
1 Katedra farmaceutické technologie, Farmaceutická fakulta UK v Hradci Králové
2 Oddělení plastické chirurgie, Sanatorium Sanus - První privátní chirurgické centrum, spol. s r. o., Hradec Králové

The ability of skin to retain water and its hydration are essential for both the appearance and function of the skin barrier. Dry skin occurs when natural hydration mechanisms are impaired, accompanied by a loss of elasticity, scaling and an unpleasant feeling of tightness. The aim of this article is to explain the mechanisms of skin hydration and describe the properties of moisturizing cosmetic products. The article discusses the mechanisms of action and examples of cosmetic humectants, emollients, and occlusives that prevent transepidermal water loss. Moisturizing cosmetics containing these ingredients are therefore essential for restoring and maintaining skin hydration. Knowledge of the composition and function of dermocosmetics can assist not only in selecting suitable products but also in educating users/patients on their proper use.

Keywords: skin barrier, hydration, humectants, natural moisturizing factor, emollients, occlusives, (dermo)cosmetics.

Accepted: February 19, 2026; Published: March 13, 2026  Show citation

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Kováčik A, Vraníková B, Čáp R. Skin hydration: How to increase the water content in the skin with dermocosmetics? Čes. slov. farm. 2026;75(1):E8-11. doi: 10.36290/csf.2026.002.
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References

  1. Elias PM. Epidermal lipids, barrier function, and desquamation. J Invest Dermatol. 1983;80(Suppl):44s-9s. Go to original source...
  2. Warner RR, Myers MC, Taylor DA. Electron probe analysis of human skin: determination of the water concentration profile. J Invest Dermatol. 1988;90:218-24. Go to original source...
  3. Caspers PJ, Lucassen GW, Puppels GJ. Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin. Biophys J. 2003;85:572-80. Go to original source...
  4. Strianse SJ. The search for the ideal moisturizer. Cosmet Perfum. 1974;89:57.
  5. Tammi R, Ripellino JA, Margolis RU, Tammi M. Localization of epidermal hyaluronic acid using the hyaluronate binding region of cartilage proteoglycan as a specific probe. J Invest Dermatol. 1998;90:412-4. Go to original source...
  6. Wehr RF, Krochmal L. Considerations in selecting a moisturizer. Cutis. 1987;39:512-5.
  7. Verdier-Sévrain S, Bonté F. Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol. 2007;6:75-82. Go to original source...
  8. Vojáčková N, et al. Suchá pokožka - možné příčiny a možnosti každodenní péče. Dermatol Praxi. 2020;14:188-92. Go to original source...
  9. Obstová I, Iličová S. Každodenní péče o suchou a citlivou pokožku. Med Praxi. 2010;7(Suppl A):???.
  10. Jarešová L. Celoroční péče o atopickou a velmi suchou pokožku. Med Praxi. 2013;10(10):344-46.
  11. Obstová I. Péče o ruce v zimě. Prakt Lékáren. 2009;5(6):294.
  12. Polášková S. Epidermální bariéra a její význam u zdravé a atopické kůže. Pediatr Praxi. 2014;15(4):210-12.
  13. Nevoralová Z, et al. Atopický ekzém - teorie i praktické rady. Dermatol Praxi. 2015;9:104-10.
  14. Gutová V, et al. Současný přístup k diagnostice a léčbě atopického ekzému. Dermatol Praxi. 2010;4:10-4.
  15. Schmiedbergerová R. Eczema atopicum. Pediatr Praxi. 2005;4:145-50.
  16. Chalupová Z, Masteiková R. Hydratace kůže a kosmetické prostředky. Prakt Lékáren. 2006;2(4):192-4.
  17. Dwayebová R. Přehled přípravků k regeneraci bariérové funkce kůže. Dermatol Praxi. 2020;14:208-12. Go to original source...
  18. Kováčik A, Vraníková B. Co (ne)víme o kosmetických přípravcích aneb kosmetologie pro farmaceuty. Prakt Lékáren. 2022;18:53-7. Go to original source...
  19. Boisits EK. The evaluation of moisturizing products. Cosmet Toilet. 1986;101:31-39. Go to original source...
  20. Jass HE, Elias PM. The living stratum corneum: implications for cosmetic formulation. Cosmet Toil. 1991;106:47-53.
  21. Holleran W, Feingold K, Man MQ, Gao W, Lee J, Elias PM. Regulation of epidermal sphingolipid synthesis by permeability barrier function. J Lipid Res. 1991;32:1151-8. Go to original source...
  22. Grubauer G, Elias PM, Feingold KR. Transepidermal water loss: the signal for recovery of barrier structure and function. J Lipid Res. 1989;30:323-33. Go to original source...
  23. Fluhr JW, Mao-Qiang M, Brown BE, et al. Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice. J Invest Dermatol. 2003;120:728-37. Go to original source...
  24. Hara M, Ma T, Verkman AS. Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration, elasticity, and barrier recovery. J Biol Chem. 2002;277:46616-21. Go to original source...
  25. Lodén M, Andersson AC, Anderson C, et al. A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients. Acta Derm Venereol. 2002;82:45-7. Go to original source...
  26. Middleton J. Development of a skin cream designed to reduce dry and flaky skin. J Soc Cosmet Chem. 1974;25:519-34.
  27. Wilkinson JB, Moore RJ. Harry's Cosmeticology. New York: Chemical Publishing; 1982:62-4.
  28. Wehr RF, Krochmal L. Considerations in selecting a moisturizer. Cutis. 1987;39:512-5.
  29. Bourguignon LY, Ramez M, Gilad E, et al. Hyaluronan-CD44 interaction stimulates keratinocytes differentiation, lamellar body formation/secretion, and permeability barrier homeostasis. J Invest Dermatol. 2006;126:1356-65. Go to original source...
  30. Dumas M, Gondran C, Senechal E, Bonté F. Stimulation of glycosaminoglycan synthesis in keratinocytes by d-Xylose. J Invest Dermatol. 1999;113:457.
  31. Draelos ZD. The science behind skin care: Moisturizers. J Cosmet Dermatol. 2018;17:138-44. Go to original source...
  32. Idson B. Dry skin: moisturizing and emolliency. Cosmet Toilet. 1992;107:69-78.
  33. Brand HM, Brand-Garnys EE. Practical application of quantitative emolliency. Cosmet Toilet. 1992;107:93-9.
  34. Lodén M. The increase in skin hydration after application of emollients with different amounts of lipids. Acta Derm Venereol. 1992;72:327-30. Go to original source...
  35. Lodén M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol. 2003;4:771-88. Go to original source...
  36. Mayoral FA, Kenner JR, Draelos ZD. The skin health and beauty pyramid: a clinically based guide to selecting topical skincare products. J Drugs Dermatol. 2014;13:414-42.




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