Čes. slov. farm. 2023, 72(3):125-131 | DOI: 10.5817/CSF2023-3-125
Comparison of the preparation of the radiopharmaceutical 68Ga-PSMA-11 at two Czech worksites
- 1 Ústavní lékárna, Masarykův onkologický ústav, Brno
- 2 Ústav aplikované farmacie, Farmaceutická fakulta MU, Brno
- 3 Ústavní lékárna, Nemocnice České Budějovice
Radiopharmaceutical 68Ga-PSMA-11 is one of the newest positron radiopharmaceuticals available for nuclear medicine departments in the Czech Republic. The radiopharmaceutical preparation can be carried out manually or instrumentally using modules for synthesis. Despite the greater technological difficulty of preparation, the success of synthesis of this radiopharmaceutical by both methods is very high, and the evaluated quality parameters of the radiopharmaceutical are comparable by both manual and instrumental preparation methods. Also, regarding professional exposure, the preparation of 68Ga-PSMA-11 does not significantly affect the whole-body and finger dosimetry results.
Keywords: Instrumentation; radiopharmacy; gallium-68; 68Ga-PSMA-11
Received: February 17, 2023; Accepted: March 28, 2023; Published: March 1, 2023 Show citation
References
- García Garzón J. R., de Arcocha Torres M., Delgado- Bolton R., Ceci F., Alvarez Ruiz S., Orcajo Rincón J., Caresia Aróztegui A. P., García Velloso M. J., García Vicente A. M. 68Ga-PSMA PET/CT in prostate cancer. Rev. Esp. Med. Nucl. Imagen Mol. (Engl. Ed.) 2018; 37(2), 130-138. doi: 10.1016/j.remn.2017.07.004
Go to original source... 
Go to PubMed... - Erdoğan M., Özkan E. E., Öztürk S. A., Yildiz M., Şengül S. S. The Role of Ga-68 PSMA PET/CT Scan on Differentiating of Oligometastatic and High Risk Prostate Cancer. Mol. Imaging Radionucl. Ther. 2020; 29(3), 98-104. doi: 10.4274/mirt.galenos.2020.89421
- Esen T., Kiliç M., Seymen H., Acar Ö., Demirkol M. O. Can Ga-68 PSMA PET/CT replace conventional imaging modalities for primary lymph node and bone staging of prostate cancer? Eur. Urol. Focus 2020; 6(2), 2018-2020. doi: 10.1016/j.euf.2019.05.005 Go to original source... Go to PubMed...
- Haberkorn U., Eder M., Kopka K., Babich J. W., Eisenhut M. New Strategies in Prostate Cancer: Prostate-Specific Membrane Antigen (PSMA) Ligands for Diagnosis and Therapy. Clin. Cancer Res. 2016; 22(1), 9-15. doi: 10.1158/1078-0432.CCR-15-0820 Go to original source... Go to PubMed...
- Bertagna F., Albano D., Cerudelli E., Gazzilli M., Giubbini R., Treglia G. Potential of Radiolabeled PSMA PET/CT or PET/MRI Diagnostic Procedures in Gliomas/Glioblastomas. Current Radiopharmaceuticals 2020; 13, 94-98. doi: 10.2174/1874471012666191017093721 Go to original source... Go to PubMed...
- Kunikowska J., Cieślak B., Gierej B., Patkowski W., Kraj L., Kotulski M., Zieniewicz K., Królicki L. [68 Ga] Ga-Prostate-Specific Membrane Antigen PET/CT: a novel method for imaging patients with hepatocellular carcinoma. Eur. J. Nucl. Med. Mol. Imaging 2021; 48(3), 883-892. doi: 10.1007/s00259-020-05017-0. Go to original source... Go to PubMed...
- Muzaffar S., Ahmed N., Rahman U., Al Kandari F., Usmani S. 68 Ga-Prostate-Specific Membrane Antigen Uptake as a Surrogate Biomarker of Neovascularity in Hepatocellular Carcinoma. Indian J. Nucl. Med. 2021; 36(1), 90-91. doi: 10.4103/ijnm.IJNM_38_20 Go to original source... Go to PubMed...
- Bertagna F., Albano D., Cerudelli E., Gazzilli M., Tomasini D., Bonu M., Giubbini R., Treglia G. Radiolabeled PSMA PET/CT in breast cancer. A systematic review. Nucl. Med. Rev. 2020; 23(1), 32-35. doi: 10.5603/NMR.2020.0004
- Sathekge M., Modiselle M., Vorster M., Mokgoro N., Nyakale N., Mokaleng B., Ebenhan T. 68Ga-PSMA imaging of metastatic breast cancer. Eur. J. Nucl. Med. Mol. Imaging 2015; 42(9), 1482-1483. doi: 10.1007/s00259-015-3066-x Go to original source... Go to PubMed...
- Kumar A., Ballal S.,Yadav M. P., ArunRaj S. T., Haresh K. P., Gupta S., Damle N. A., Garg A., Tripathi M., Bal Ch. 177Lu-/68Ga-PSMA Theranostics in Recurrent Glioblastoma Multiforme. Clin. Nucl. Med. 2020; 45(2), e512-e513. doi: 10.1097/RLU.0000000000003142 Go to original source... Go to PubMed...
- Kunikowska J., Charzyńska I., Kuliński R., Pawlak D., Maurin M., Królicki L. Tumor uptake in glioblastoma multiforme after IV injection of [177Lu] Lu-PSMA-617. Eur. J. Nucl. Med. Mol. Imaging 2020; 47(6), 1605-1606. doi: 10.1007/s00259-020-04715-z Go to original source... Go to PubMed...
- Plichta K. A., Graves S. A., Buatti J. M. Prostate-Specific Membrane Antigen (PSMA) Theranostics for Treatment of Oligometastatic Prostate Cancer. Int. J. Mol. Sci. 2021; 22(12095). doi: 10.3390/ijms222212095 Go to original source... Go to PubMed...