Čes. slov. farm. 2012, 61(3):130-132

Studies of local anaesthetics - Part 197. Effect of xylitol on pharmaceutical availability of lidocaine and flow properties of hydrogels

Zuzana Vitková¹, Petra Herdová^1,*, Jozef Čižmárik², Daniel Grančai³, Lukáš Benč¹

¹ Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra galenickej farmácie

² Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra farmaceutickej chémie

³ Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra farmakognózie a botaniky

The paper examines the formulation of hydrogel on the base of a synthetic polymer containing a local anaesthetic and a mass-produced drug in the form of a solution with an antiphlogistic effect. It aimed to prepare a hydrogel of a suitable composition with suitable flow properties and drug release, the active ingredient being lidocaine hydrochloride. Besides the role of a synthetic polymer which ensures that the active ingredient remains at the affected site, an important role in the formulation is played by the presence of an artificial sweetener, which to a great extent as a taste correcting agent of the unpleasant taste of the active ingredient influences the compliance of many patients. The study examined the effect of concentration of the artificial sweetener xylitol on the liberation of the active ingredient from prepared hydrogels. The optimum concentration of the artificial sweetener was adjusted to a degree which does not affect the qualitative properties of the active ingredient.

Keywords: lidocaine hydrochloride; xylitol; hydrogel; liberation

Grants and funding:

Tento výskum bol podporený grantami VEGA č. 1/0024/11 a 1/0055/11 a grantom FaF 8/2012.

Received: March 15, 2012; Accepted: April 15, 2012; Published: March 1, 2012  Show citation