JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2003, 52(6):306-309

Anticomplementary Activity of Saponins from Cynara cardunculus L.

P. Mučaji1, M. Bukovský2, D. Grančai1, M. Nagy1
1 Katedra farmakognózie a botaniky Farmaceutickej fakulty Univerzity Komenského, Bratislava
2 Katedra bunkovej a molekulárnej biológie liečiv Farmaceutickej fakulty Univerzity Komenského, Bratislava

Triterpene saponins of ursane and oleane type isolated from the involucral bracts of Cynara cardunculus L. (Asteraceae) were investigated in in vitro assays for their activity on the complement system. The anticomplementary activity of bidesmosidic saponins on the classical pathway activation of the complement was higher than the activity of monodesmosidic saponins, but esterificationof the carboxylic group of glucuronic acid in the sugar residue resulted in a significant decrease in anticomplementary activity.

Keywords: Cynara cardunculus L.; Asteraceae; saponins; triterpenes; anticomplementary activity

Published: June 1, 2003  Show citation

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Mučaji P, Bukovský M, Grančai D, Nagy M. Anticomplementary Activity of Saponins from Cynara cardunculus L. Čes. slov. farm. 2003;52(6):306-309.
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