Čes. slov. farm. 1999, 48(6):276-280

Studies of Local Anaesthetics CL. Models of Dependence of Local Anaesthetic Effectiveness of Basic Esters of Alkoxy-substituted Phenylcarbamic Acids on the Capacity Factor k'

J. Čižmárik¹, J. Lehotay², A. Bednáriková², K. Hroboňová²

¹ Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava

² Katedra analytickej chémie Chemickotechnologickej fakulty Slovenskej technickej univerzity, Bratislava

On the basis of proposed six models of the dependence of local anaesthetic effectiveness of series ofalkoxysubstituted derivatives of phenylcarbamic acid, this activity was studies in dependence onthe capacity factor k' as the parameter of lipophilicity. The most suitable models proved to be y =(Cx + Ci).k' for surface anaesthesia, and y = Cx + Ci log k' for infiltration anaesthesia, y being thevalue of the decadic logarithm of surface or infiltration local anaesthetic activity, Cx the coefficientcharacterizing the nitrogenous base, Ci the coefficient characterizing the individual alkoxygroups,and k' the capacity factor from HPLC.

Keywords: local anaesthetic activity; derivatives of alkoxyphenylcarbamic acid; capacity factor k'; dependence

Published: June 1, 1999  Show citation