Čes. slov. farm. 2023, 72(2):95-99 | DOI: 10.5817/CSF2023-2-95

Antimicrobial properties of the new combined dental gel

Nataliia Dev Atkina

Department of Pharmacology, Clinical Pharmacology and Pharmacy, Poltava State Medical University, Poltava, Ukraine

Given the role of the microbial factor in the development of infectious-inflammatory processes in the oral mucosa, the research aim was to study the antimicrobial action of a new combined dental gel containing Rotocan® (10%) and triclosan (0.4%) in vitro and in the traumatic stomatitis in albino rats. Rotrin-Denta® exhibited strong antimicrobial activity against etalon strains of gram-positive (S. aureus ATTC 6538, S. pyogenes DICK 1, B. subtilis ATCC 6633) and gramnegative (E. coli ATCC 25922) bacteria, which exceeded the action of the reference drug Camident-Zdorovia® and weak effects on pseudomonads (P. aeruginosa ATCC 27853) and fungi (C. albicans CCV 885-653), which is less to the reference preparation. Rotrin- Denta® reduced microbial insemination and eliminated oral dysbiosis in albino rats with traumatic stomatitis, exceeding the effect of Kamident-Zdorov'ya®. The results open up the prospect of its clinical testing and further implementation in the dentistry practice.

Keywords: dysbiosis; dental gel; microorganisms susceptibility; traumatic stomatitis

Grants and funding:

The work was performed within the planned initiative research work of the Department of Pharmacology, Clinical Pharmacology and Pharmacy of the Poltava State Medical University «Pharmacological study of biologically active substances and drugs for the correction of homeostasis disturbances of various etiologies», state registration number 0117U004681.

Received: January 2, 2023; Accepted: March 9, 2023; Published: February 1, 2023  Show citation