JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2022, 71(4):149-158 | DOI: 10.5817/CSF2022-4-149

Investigation of the antimicrobial and antifungal activities of some 1,2,4-triazole derivatives

Yuliia Frolova1,*, Andrii Kaplaushenko1, Sameliuk Yurii1, Daria Romanina2, Liubov Morozova3
1 Zaporizhzhia State Medical University, Department of Physical and Colloidal Chemistry, Ukraine
2 Zaporizhzhia State Medical University, Department of Medicines Technology, Ukraine
3 Vinnytsia National Agrarian University, Department Technologies, Processing of Livestock Products and Feeding, Ukraine

This article presents the results of the study of the antimicrobial and antifungal properties among 1,2,4-triazole derivatives synthesized at the Department of Physical and Colloidal Chemistry of the Zaporizhzhia State Medical University. Previous studies have established the antimicrobial and antifungal activity of 1,2,4-triazole derivatives. Therefore, it was reasonable to investigate highly effective substances with antimicrobial and antifungal properties among synthesized compounds. In the first stage of our research, acute toxicity prediction was performed. The antimicrobial and antifungal properties were carried out by the method of "serial dilutions" on a liquid nutrient. Forty-seven compounds of the different classes were studied for these types of activities. According to our research, derivatives of 3-amino-1,2,4-triazole showed better performance than 3-thio-1,2.4-triazoles for Staphylococcus aureus and Candida albicans. 5-(1Н-tetrazole-1-іl)methyl-4Н-1,2,4-triazole-3-yl-1-(5-nitrofuran-2-yl)methanimin (11.6) was showed the greatest antimicrobial and antifungal activity. Deeper research for compound 11.6 was done by diffusion in agar (method of "wells"). Studies have shown that molecule 11.6 showed antimicrobial and antifungal action to the studied test strains at a concentration of 2 μg/ml. Hence, this compound can be developed as a helpful therapeutic agent after establishing its safety pharmacology and toxicity.

Keywords: 1,2,4-triazole; antimicrobial activity; antifungal activity

Received: February 15, 2022; Accepted: August 1, 2022; Published: April 1, 2022  Show citation

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Frolova Y, Kaplaushenko A, Yurii S, Romanina D, Morozova L. Investigation of the antimicrobial and antifungal activities of some 1,2,4-triazole derivatives. Čes. slov. farm. 2022;71(4):149-158. doi: 10.5817/CSF2022-4-149.
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