Čes. slov. farm. 2020, 69(4):163-171 | DOI: 10.36290/csf.2020.024

Collagen in combination with the acid form of carboxymethylcellulose in the form of a nonwoven textile as a modern wound dressing - formulation, preparation and evaluation

Kateřina Tenorová^1,*, Ruta Masteiková¹, Jana Jarábková¹, David Vetchý¹, Jurga Bernatonienė²

¹ Masarykova univerzita, Farmaceutická fakulta, Ústav farmaceutické technologie, Brno

² Akademie medicíny, Litevská univerzita zdravotnických věd, Farmaceutická fakulta, Katedra technologie léků a sociální farmacie, Kaunas, Litva

The acid form of carboxymethylcellulose (HCMC) is less known than its sodium salt (NaCMC). However, it is commonly used as a sorbent for chromatographic columns and has a number of valuable properties for its use in wound care. As a wound dressing in the form of hydrofibers, it is already commercially available on our market. Collagen, the most abundant protein in the human body, fulfils both a building and a physiological function in the body, also has an irreplaceable place in the treatment of wounds. It is important in the process of wound healing and is used in wound therapy in various forms. It exhibits very good film-forming properties as well, but the collagen-based films themselves have weaker mechanical resistance, which limits their successful application to a wound. Therefore, the effort is to combine collagen with other materials in order to ensure better mechanical and application properties even in the wet state. The aim of this experiment was to create a wound dressing by combining a collagen film with HCMC in the form of a nonwoven textile. The resulting dressing had satisfactory organoleptic, physicochemical (pH, absorbency) and application properties for its use in wound therapy. The textile HCMC formed a mechanical support for collagen, which enabled its saving during the dressing preparation and partly served as an absorbent layer.

Keywords: wound dressing; collagen; acid form of carboxymethylcellulose; hydrofibers; films; wound therapy

Grants and funding:

Práce vznikla za podpory IGA VFU Brno, Česká republika pod číslem (304/2019/FaF).

Received: July 31, 2020; Accepted: August 25, 2020; Published: April 1, 2020  Show citation