JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2020, 69(3):130-136 | DOI: 10.36290/csf.2020.020

Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone

Lucie Černá1,2, Zuzana Baďo1, Petra Šalamúnová4, Karel Šmejkal1,3, Jaroslav Hanuš4, Jan Hošek2,*
1 Farmaceutická fakulta, Masarykova univerzita, Brno
2 Přírodovědecká fakulta, Univerzita Palackého, Oddělení biologicky aktivních komplexů a molekulových magnetů, Regionální centrum pokročilých technologií a materiálů, Olomouc
3 Univerzita veterinárskeho lekárstva a farmácie, Katedra farmakognózie a botaniky, Košice, SR
4 Vysoká škola chemicko-technologická, Praha, Ústav chemického inženýrství, Fakulta chemicko-inženýrská

Geranylated flavanone diplacone is a flavanone isolated from Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae) with anti-inflammatory and antioxidant properties, nevertheless showing high lipophilicity and low solubility in water. Diplacone was therefore used as a model molecule for incorporation into glucan particles (GPs). GPs are prepared by intensive washing of yeast (Saccharomyces cerevisiae) leading to hollow shells consisting of β-(1→3)/β-(1→6) glucan mainly. The aim of this study was to compare anti-inflammatory potential of GPs-diplacone composites with the compound itself, GPs themselves and the physical mixture of GPs and diplacone. The cell line THP1-XBlueTM-MD2-CD14 derived from human leukemic monocytes was stimulated with lipopolysaccharide (LPS) from Escherichia coli to trigger inflammatory reaction. The composites of GPs with diplacone significantly decreased the activity of pro-inflammatory transcription factors nuclear factor κB (NF-κB) and activator protein 1 (AP-1).

Keywords: AP-1; diplacone; encapsulation; glucan particles; NF-κB; inflammation
Grants and funding:

Podpořeno z programového projektu Ministerstva zdravotnictví ČR s reg. č. 16-27522A.

Received: March 25, 2020; Accepted: April 28, 2020; Published: March 1, 2020  Show citation

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Černá L, Baďo Z, Šalamúnová P, Šmejkal K, Hanuš J, Hošek J. Anti-inflammatory potential of composites of yeast glucan particles and geranylated flavonoid diplacone. Čes. slov. farm. 2020;69(3):130-136. doi: 10.36290/csf.2020.020.
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