JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2017, 66(4):164-167 | DOI: 10.36290/csf.2017.025

Synergistic effect of azole antimycotics (clotrimazole and fluconazole) and natural substances

Martin Kuruc, Eva Čonková*
Univerzita veterinárskeho lekárstva a farmácie v Košiciach, Ústav farmakológie, Košice, Slovenská republika

Nowadays the treatment of fungal infections is difficult due to increasing resistance of fungal pathogens to antimycotics. The efficacy of antimycotics can be increased by a proper combination of commercial drugs and natural substances. The 100% antimycotic activity was found using susceptibility testing of Candida albicans yeasts on clotrimazole alone and in combination with tea tree oil, or with a multicomponent preparation containing cannabis oil and various essential oils and in combination with propolis tincture. Combination of natural substances with fluconazole seems to be also prospective. Fluconazole alone achieved an antifungal activity of 80.95% but natural active substances increased its efficacy by 9.55-14.25%.

Keywords: Candida albicans; fluconazole; clotrimazole; natural active substances; synergism
Grants and funding:

Práca bola podporovaná Agentúrou na podporu výskumu a vývoja na základe Zmluvy č. APVV-15-0377

Received: June 4, 2017; Accepted: July 11, 2017; Published: April 1, 2017  Show citation

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Kuruc M, Čonková E. Synergistic effect of azole antimycotics (clotrimazole and fluconazole) and natural substances. Čes. slov. farm. 2017;66(4):164-167. doi: 10.36290/csf.2017.025.
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