JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2013, 62(5):220-222

Evaluation of liberation of caffeine from dermal semisolids drugs

Alexandra Kodadová*, Zuzana Vitková, Petra Herdová
Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra galenickej farmácie, Bratislava, Slovenská republika

The paper deals with formulation of caffeine into dermal semisolid dosage forms - hydrogels. Caffeine was chosen as a model drug because its properties can be successfully used just in hydrogels. Protective and tranquilization effects can be used in the preparations for sunbathing, and its lipolytic and regenerative effect can be used for the treatment of androgenic alopecia or cellular bioprotection. The aim of the study was to investigate the influence of different concentrations of chitosan and caffeine on the liberation of gels. Besides, stability of the prepared samples was evaluated by means of the evaluation of their rheological parameters. Based on the obtained results, there was determined the optimal drug concentration - caffeine 0.2% (w/w) and also the gel forming substance - chitosan 2.3% (w/w).

Keywords: caffeine; hydrogels; chitosan; liberation; rheological parameters
Grants and funding:

Výskum bol podporený grantami UK/101/2013, VEGA 1/0024/11, FAF UK/3/2013.

Received: August 26, 2013; Accepted: September 14, 2013; Published: May 1, 2013  Show citation

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Kodadová A, Vitková Z, Herdová P. Evaluation of liberation of caffeine from dermal semisolids drugs. Čes. slov. farm. 2013;62(5):220-222.
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    References

    1. Velasco M. V. R., Tano C. T. N., Machado-Santelli G. M., Consiglieri V. O., Kaneko T. M., Baby A. R. Effects of caffeine and siloxanetriol alginate caffeine, as anticellulite agents, on fatty tissue: histological evaluation. JCD. 2008; 7, 23-29. Go to original source... Go to PubMed...
    2. Bansal M., Manchanda K., Pandey S. S. Role of Caffeine in the Management of Androgenetic Alopecia. Int J Trichology 2012; 4, 185-186. Go to original source... Go to PubMed...
    3. Herdová P., Vitková Z. Štúdium liberácie liečiv z chitosanových hydrogélov. Derma 2010; 10, 20.

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