JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2010, 59(6):277-279

Study of local anaestetics - Part 192. Formulation of lidocaine into gels with anti-inflammatory effect

J. Čižmárik1, D. Matušová2, Z. Vitková3, B. Brázdovičová3, P. Herdová3,*
1 Comenius University Bratislava, Faculty of Pharmacy, Department of Pharmaceutical Chemistry
2 Slovak Medical University, Department of Pharmaceutical Technology
3 Comenius University Bratislava, Faculty of Pharmacy, Department of Galenic Pharmacy

The paper deals with the formulation of hydrogels with anti-inflammatory effect for oral application. Liberation of lidocaine from hydrogels with zinc chloride and Bukofit solution as well as the rheological properties of the prepared dermal semisolid dosage forms revealed that addition of zinc chloride and Bukofit positively influences liberation of lidocaine and the properties of the gel itself.

Keywords: gels; lidocaine; Carbopol; anti-inflammatory drugs

Received: October 20, 2010; Accepted: November 16, 2010; Published: June 1, 2010  Show citation

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Čižmárik J, Matušová D, Vitková Z, Brázdovičová B, Herdová P. Study of local anaestetics - Part 192. Formulation of lidocaine into gels with anti-inflammatory effect. Čes. slov. farm. 2010;59(6):277-279.
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    References

    1. Enterprise norm Calendula, a.s. Nová Ľubovňa, PN-08-002-02 (2002) Bukofit solution. Go to original source...
    2. Kolodziejska, J.: Carbopol 974 P in the prescription of dental anti-inflammatory hydrogels. Polim. Med., 2008; 38, 27-38.
    3. Brázdovičová, B., Vitková, Z., Grančaiová, K., Liščáková, A.: Influence of exogenous factors on rheological properties of Carbopol 940 hydrogels. Farm. Obzor., 2008; 77, 211-214.

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