Čes. slov. farm. 2009, 58(2):47-54

Beneficial effects of rutin, quercitrin and quercetin on inflammatory bowel disease

M. Rabišková^1,*, T. Bautzová¹, K. Dvořáčková¹, J. Spilková²

¹ University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy, Department of Pharmaceutics, Czech Republic

² Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmacognosy, Czech Republic

The aim of this review article was to obtain a deeper understanding of the reported effects of flavonols, in particular rutin, quercitrin and their aglycone quercetin, with respect to their potential beneficial action on inflammatory bowel disease. Research in the field of flavonoids has increased significantly in recent few years and many new investigations have been performed concerning their absorption, metabolism, and probable mechanisms of action. Recently published results obtained in in vitro approaches and in vivo experiments on animal models are reported. Further investigation aimed at the clinical effects of rutin may be important for the development of a new therapeutic agent for the treatment of inflammatory bowel disease in humans.

Keywords: inflammatory bowel disease; flavonols; absorption; metabolism; effects

Grants and funding:

This work was supported by the Research Project MSM 0021620822 and IGA VFU 253/2009/FaF.

Received: March 24, 2009; Accepted: April 8, 2009; Published: February 1, 2009  Show citation