JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2007, 56(6):259-263

Oxycellulose - a cellulose derivative with a potential to become an active pharmaceutical substance as well as an auxiliary substance

J. Gajdziok, M. Bajerová, Z. Chalupová, R. Masteiková
Veterinární a farmaceutická univerzita Brno, Farmaceutická fakulta, Ústav technologie léků

The review article is focused on one of the wide range of pharmaceutically and medicinally employed cellulose derivates - oxycellulose. This substance, prepared by oxidation of cellulose, in contrast to cellulose esters and ethers, has not been not employed in practice in a wide extent yet. However, recent studies reveal its potential use in modern therapeutical systems, whether as a release-modifying excipient, a drug carrier, or also an active substance with ability of hemostasis, prevention of tissue adhesion after surgical operations, and a substance with antimicrobial and immunomodulating activity, whose unique property of biodegradability, promoted by hypoallergenicity and non-irritability, has not been observed in any of the hitherto used cellulose derivates. The article presents a comprehensive overview about the history of this derivate, from its physico-chemical properties through the description of the ability of biodegradability to its already realized and planned utilization.

Keywords: oxycellulose; oxidized cellulose; biodegradability; hemostasia; modern therapeutical systems

Received: October 2, 2007; Accepted: October 30, 2007; Published: June 1, 2007  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Gajdziok J, Bajerová M, Chalupová Z, Masteiková R. Oxycellulose - a cellulose derivative with a potential to become an active pharmaceutical substance as well as an auxiliary substance. Čes. slov. farm. 2007;56(6):259-263.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Stillwell, R. L. et al.: Handbook of Biodegradable Polymers, (Domb, A. J., Kost, J., Wiseman, M. W. eds.), London: Harwood Academic Publishers, 1997, s. 291-306
    2. Chen, L. F., Seethanathan, P.: United States Patent US4480089, 1984.
    3. USP 29: Oxidized Cellulose, Oxidized Regenerated Cellulose, s. 444-445.
    4. Rabišková, M. et al.: Chemické listy, 2007; 101, 70-77.
    5. Sedláková, M. et al.: Čes. slov. Farm., 2006; 55, 4-11.
    6. Schmidt, R., Bogan, D., Moore, J.: European Patent EP1153618, 2001.
    7. Watt, P. W., Harvey, W., Lorimer, E., Wiseman, D.: World Patent WO9800180, 1998.
    8. Jelínková, M., Briestenský, J., Santar, I., Říhová, B.: Int. Immunol., 2002; 2, 1429-1441. Go to original source... Go to PubMed...
    9. Zhu L., Kumar V., Banker G. S.: Int. J. Pharm., 2000; 223, 35-47. Go to original source... Go to PubMed...
    10. Kumar, V., Yang, T.: Carbohyd. Polym., 2002; 48, 403-412. Go to original source...
    11. http://www.synthesia.cz/cs/produkty/podle-sbu/nitroceluloza/oxyceluloza-a-jeji-soli/ 10. 11. 2006.
    12. Zimnitsky, D. S., Yurkshtovich, T. L., Bychkovsky, P. M.: J. Colloid. Interface Sci., 2006; 295, 33-40. Go to original source... Go to PubMed...
    13. Santar, I., Kiss, F., Briestensky, J.: World Patent WO9833822, 1998.
    14. Dimitrijevich, S. D., Tatarko, M., Gracy, R. W.: Carbohyd. Res., 1990; 195, 247-256. Go to original source... Go to PubMed...
    15. Dimitrijevich, S. D., Tatarko, M., Gracy, R. W. et al.: Carbohyd. Res., 1990; 198, 331-341. Go to original source... Go to PubMed...
    16. Yackel, E. C., Kenyon, W. O.: United States Patent US2232990, 1941.
    17. Nada Abd-Allah, M. A., Hassan Mohammad, L. : Cellulose and Paper Department, National Research Center, Dokki, Cairo, Egypt 12622, 2006.
    18. Ashton, W. H.: United States Patent US3364200, 1968.
    19. Bertocchi, C., Konowicz, P., Signore, S. et al.: Carbohyd. Res., 1995; 27, 295-297. Go to original source...
    20. Nevell, T. P.: Ellis Horwood, New York, 1985, 243-265.
    21. Walimbe, A. M., Pandya, B. N., Lalla, J. K.: Res. Ind., 1978; 23, 162-165.
    22. Gert, E. V., Shishonok, O. V., Zubets, O. V. et al.: J. Polym. Sci. A-Polym. Chem., 1995; 37, 670-675.
    23. Státní výzkumný ústav textilní: Britský patent GB1593513, 1981
    24. Wanleg, H.: United States Patent US2758112, 1956.
    25. Painter, T. J.: Carbohyd. Res., 1977; 55, 95. Go to original source...
    26. Wei, S., Kumar, V., Banker, G. S.: Int. J. Pharm., 1996; 142, 175-181. Go to original source...
    27. Heinze, T., Klemm, D., Schnabelrauch, M., Nehls, I.: Cellulosics: chemical, biochemical and material aspects. Ellis Horwood, New York, 1993, 349-355.
    28. Banker, S. G., Kumar, V.: United States Patent US5405953, 1995.
    29. Saito, T., Okita, Y., Nge, T. T. et al.: Carbohyd. Polym., 2006; 65, 435-440. Go to original source...
    30. Kato, K., Vasilets, V. N., Fursa, M. N. et al.: J. Polym. Sci. A-Polym. Chem., 1999; 37, 357-361. Go to original source...
    31. Otterlei, M., Espvik, T., Skjak-Braek, G., Smidsrod, O.: United States Patent US5169840, 1992.
    32. Brandon, G. J.: World Patent WO2006006140, 2006.
    33. Možíšek, M., Černý, P., Možíšková, J. et al.: Český patent CS253042, 1988.
    34. Banker, G. S., Kumar, V.: United States Patent US5780618, 1998.
    35. Varma, A. J., Chavan, V. B.: Polym. Degrad. Stabil., 1995; 49, 245-250. Go to original source...
    36. Sheleg, S. V., Korotkevich, E. A., Zhavrid, E. A. et al.: J. Neuro-Oncol., 2002; 60, 53-59. Go to original source... Go to PubMed...
    37. Zhu, L., Kumar, V., Banker, G. S.: AAPS PharmSciTech, 2004; 5. Go to original source... Go to PubMed...
    38. Zimnitsky, D. S., Yurkshtovich, T. L., Bychkovsky, P. M.: J. Colloid. Interface Scie., 2005; 285, 502-508. Go to original source... Go to PubMed...
    39. Vetchý, D., Ceral, J.: Neurologie pro praxi, 2005; 4, 218220.
    40. Singh, M., Ray, A. K., Vasudevan, P.: Biomaterials, 1982; 3. Go to original source... Go to PubMed...
    41. Bala, K., Guha, S. K., Vasudevan, P.: Biomaterials, 1982; 3. Go to original source... Go to PubMed...
    42. Gert, E. V., Torgashov, V. I., Zubets, O. V., Kaputskii, F. N.: Cellulose, 2005; 12, 517-526. Go to original source...
    43. Jin, B., Wu, W.-Y.: World Patent WO2005020997, 2005.
    44. Cohen, E. C.: United States Patent US4597960, 1986.
    45. Dvořáčková, K., Masteiková, R., Rabišková, M., Vocilková, L.: Čes. slov. Farm., 2007; 56(3), 129-134.

    Return to the content


    Czech and Slovak Pharmacy

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.