JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2004, 53(5):225-227

HPLC Determination of Diperodon Enantiomers in Blood Serum by Using Teicoplanin Chiral Stationary Phase

K. Hroboňová1, J. Lehotay1, J. Čižmárik2
1 Katedra analytickej chémie Fakulty chemickej a potravinárskej chémie Slovenskej technickej univerzity, Bratislava
2 Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava

The chiral stationary phase on the base of teicoplanin and the polar-organic mobile phase methanol/acetonitrile/acetic acid/triethylamine 45/55/0.3/0.2 was used for the separation of diperodonenantiomers. The developed method was suitable to determine the enantiomers in blood serum upto 0.5 µg/ml. The degradation of diperodon enantiomers was studied in serum by an in vitro methodand the experimental rate constants were determined.

Keywords: HPLC; teicoplanin; enantiomers; diperodon; enzymatic hydrolysis; rate constants

Published: May 1, 2004  Show citation

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Hroboňová K, Lehotay J, Čižmárik J. HPLC Determination of Diperodon Enantiomers in Blood Serum by Using Teicoplanin Chiral Stationary Phase. Čes. slov. farm. 2004;53(5):225-227.
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