JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2004, 53(2):96-98

Effect of Auxiliary Substances on the Physicochemical Indices of the Solutions of Substance XXII B

Z. Vitková, K. Gardavská, M. Šubová, E. Cirbusová, M. Mišeková
Katedra galenickej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava

Within a study of optimization of auxiliary substances in the formulation of a hydrogel containinga potential local anaesthetic agent, substance XXII B, the paper evaluated the effect of a preservative(Ajatin) and humectants (glycerol, propylene glycol, sorbitol) on selected physicochemicalindices, which included the partition coefficient, surface tension, and viscosity of the solutions ofpotential drug XXII B. On the basis of the statistical evaluation of the results, the optimalcombination of auxiliary substances in this case seems to be Ajatin + glycerol.

Keywords: potential drugs XXII B; humectants; preservatives; physiochemical indices

Published: February 1, 2004  Show citation

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Vitková Z, Gardavská K, Šubová M, Cirbusová E, Mišeková M. Effect of Auxiliary Substances on the Physicochemical Indices of the Solutions of Substance XXII B. Čes. slov. farm. 2004;53(2):96-98.
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