Čes. slov. farm. 2003, 52(5):252-257

Extraction-Spectrophotometric Determination of Carbethopendecinium Bromide inSelected Medicinal Preparations

M. Lašková, M. Blešová

Ústav chemických léčiv Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno

The paper elaborated the conditions for the determination of carbethopendecinium bromide withbromthymol blue and methyl orange (concentration of the drug and the colouring agent, pH of theaqueous phase, period of extraction with chloroform). Within a carbethopendecinium bromideconcentration range of 1.10-5 to 6.10-5 mol/l, the linear dependence of absorbance of the ion-associatewith the colouring agent on concentration was confirmed. At pH 3 and pH 10, the above-describedprocedure was used to determine the content of carbethopendecinium bromide in medicinal preparations(eye and nasal drops) using the calibration curve and comparison with one standard. Theresults were reproducible and the found deviations from the declared content ranged withina tolerance of ± 10 %.

Keywords: extraction-spectrophotometric determination; carbethopendecinium bromide; ion-associates; drug analysis

Published: May 1, 2003  Show citation