Čes. slov. farm. 2002, 51(2):73-77

Effects of Consupren, Carvedilol and BL-443 on Lactate Dehydrogenase Pattern in Tissues of Rats with Cyclosporine Nephropathy

J. Šalplachta¹, V. Strnadová², J. Csöllei³

¹ Ústav biochemie a biofýziky Fakulty veterinární hygieny a ekologie Veterinární farmaceutické univerzity, Brno

² Ústav humánní farmakologie a toxikologie Farmaceutické fakulty a Veterinární farmaceutické univerzity, Brno

³ Ústav chemických léčiv Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno

L-Lactate dehydrogenase pattern in tissues was determined by polyacrylamide gel electrophoresis adjusted to be more sensitive to LDl and LD2. Three groups of rats (Wistar) were treated for 18 days with single oral daily doses of 45 mg consuprene/kg body weight to induce cyclosporine nephropathy. Two treated groups were further medicated either with carvedilol or BL-443 in single daily doses of 10 mg/kg b.w., unmedicated rats were given single i.p. daily doses of 1 ml saline. No significant difference in the LD(1-4) isoenzyme pattern in the liver between intact rats, rats with cyclosporine nephropathy, and rats with cyclosporine nephropathy medicated with carvedilol or BL-443 was found by F-test and t-test (p

Keywords: consupren; carvedilol; cyclosporine nephropathy; L-lactate dehydrogenase isoenzymes

Published: February 1, 2002  Show citation