JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2001, 50(6):303-307

HPLC Analysis of Non-Steroidal Antirheumatics in Biological Material V. Fenamates

J. Sochor, J. Klimeš, J. Sedláček, M. Hnilová
Katedra farmaceutické chemie a kontroly léčiv Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
Katedra patologické fyziologie Lékařské fakulty Univerzity Karlovy, Hradec Králové

The present paper surveys published HPLC methods estimating derivates of fenamic acid inbiological materials and an HPLC method for estimation of meclofenamic acid in the samples ofwhole blood. Meclofenamic acid was isolated from the sample of the blood both liquid-liqud extractionand solid-liquid extraction. For determination of meclofenamic acid in the blood was preferredsolid-liquid extraction. The adjust sample was analysed on reverse phase Separon SGX C-18 withthe mobile phase methanol - water (pH 2.3) and detected at 220 nm. The method was used ina pharmacokinetic study of meclofenamic acid on rabbits.

Keywords: HPLC; review of fenamic acid derivates; meclofenamic acid; blood samples; pharmacokinetics

Published: June 1, 2001  Show citation

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Sochor J, Klimeš J, Sedláček J, Hnilová M. HPLC Analysis of Non-Steroidal Antirheumatics in Biological Material V. Fenamates. Čes. slov. farm. 2001;50(6):303-307.
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