JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2000, 49(4):195-198

Evaluation of the Quality of Mexiletine Hydrochloride by Means of CapillaryElectrophoresis

B. Proksa, A. Proksová
Slovakofarma, a. s., Hlohovec

Mexiletine hydrochloride and its potential impurity xylenol were determined by micelar electrokinetic chromatography in a 25 cm long capillary. The effect of parameters - temperature, electricfield, concentration of analyzed compounds, type and composition of background electrolyte - on theseparation of analytes and precision of analysis was studied. The advantage of the elaboratedmethod is a very short time of analysis (2.3 min) at the sufficient level of precision and reliabilityof results.

Keywords: mexiletine hydrochloride; xylenol; separation; determination; micelarelectrokinetic chromatography.

Published: April 1, 2000  Show citation

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Proksa B, Proksová A. Evaluation of the Quality of Mexiletine Hydrochloride by Means of CapillaryElectrophoresis. Čes. slov. farm. 2000;49(4):195-198.
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