JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2024, 73(3):E7-E12 | DOI: 10.36290/csf.2024.032

Novel pyrazole bearing heterocyclic hybrids as promising biologically active compounds

Kostiantyn Shabelnyk1, Yevhen Zaika2, Dmytro Skoryna1, Inna Nosulenko3, Anna Kinichenko3, Oleksii Voskoboinik4, Serhii Kovalenko5
1 Department of Pharmaceutical, Organic and Bioorganic chemistry, Zaporizhzhia State Medical and Pharmaceutical University, Mariia Pryimachenko av. 26, Zaporizhzhia, 69035, Ukraine.
2 Enamine Ltd, Kyiv, Ukraine, Winston Churchill st. 78, Kyiv, 02094 Ukraine.
3 Department of Pharmacognosy, Pharmacology and Botany, Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine, Mayakovski av. 26, Zaporizhzhia, 69035, Ukraine.
4 Department of Composite Materials, Chemistry and Technologies, National University „Zaporizhzhia Polytechnic“, Universytetska st. 64, Zaporizhzhia, 69063, Ukraine.
5 Research Institute of Chemistry and Geology, Oles Honchar Dnipro National University, Ukraine, 72, Nauky av., Dnipro, 49010, Ukraine.

The paper presents the results of a study devoted to the synthesis, evaluation of physicochemical properties, antiradical, and antimicrobial activity of pyrazole-containing heterocyclic hybrids. It has been shown that pyrazole bearing heterocyclic hybrids that contain quinazoline, triazoloquinazoline or triazole moieties are available via a series of reactions that include the interaction of 4-chloroquinazoline with pyrazole-containing hydrazides, cyclization of formed products into corresponding triazoloquinazolines, and hydrolytic cleavage of the electron-deficient tricyclic system. The structures of synthesized compounds have been verified by a complex of physicochemical methods, and the features of 1H NMR spectral characteristics have been described as well. The evaluation of obtained compounds’ biological activity revealed a moderate bacteriostatic effect against Pseudomonas aeruginosa and Candida albicans, as well as high radical scavenging activity of some of the studied heterocyclic hybrids.

Keywords: heterocyklické hybridy, pyrazol, chinazolin, triazol, antiradikálová aktivita

Accepted: September 23, 2024; Published: October 8, 2024  Show citation

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Shabelnyk K, Zaika Y, Skoryna D, Nosulenko I, Kinichenko A, Voskoboinik O, Kovalenko S. Novel pyrazole bearing heterocyclic hybrids as promising biologically active compounds. Čes. slov. farm. 2024;73(3):E7-12. doi: 10.36290/csf.2024.032.
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