JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2012, 61(5):229-233

A study of a co-processed dry binder composed of microcrystalline cellulose and glycerol monostearate

Jitka Mužíková*, Sandra Muchová
Department of Pharmaceutical Technology Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic

The paper studies the co-processed dry binder LubriToseTM MCC from the viewpoint of energy evaluation of the compression process, strength and disintegration time of tablets. The results were compared with the identical evaluation of physical mixtures of microcrystalline cellulose with several types of lubricants. LubriTose MCC showed the lowest value of energy for friction, the highest value of energy accumulated by the tablet, and the highest plasticity of all tableting materials under study. There were no marked differences in the values of the energy of decompression. The tensile strength of tablets from LubriTose MCC was lower than in those from the mixture of Vivapur® 12 and glycerol monostearate, in the compression forces of 4 and 5 kN it was comparable with the tensile strength of tablets from Vivapur 12 with Poloxamer 407. Disintegration time of tablets from LubriTose MCC was shorter than that of those from Vivapur 12 with glycerol monostearate at the compression force of 3 kN, in the case of the compression forces of 4 and 5 kN no statistically significant difference was found between the values of these tableting materials.

Keywords: LubriTose MCC; Vivapur 12; lubricants; tensile strength of tablets; disintegration time of tablets; energy profile of compression
Grants and funding:

The study was supported by the firm Kerry Bio-Science and JRS Pharma GmbH & Co. KG, which supplied the samples of the dry binders tested.

Received: August 23, 2012; Accepted: September 18, 2012; Published: May 1, 2012  Show citation

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Mužíková J, Muchová S. A study of a co-processed dry binder composed of microcrystalline cellulose and glycerol monostearate. Čes. slov. farm. 2012;61(5):229-233.
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