JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2005, 54(3):109-113

Pre-Formulation Studies of the H1-Antihistamine Loratadine for a Topical Dosage Form

Z. Capková, Z. Vitková, V. Vysokaiová
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie

The paper focuses on the formulation of the antihistamine loratadine for hydrogels. In the first stage of this study, the evaluated polymer for the preparation of hydrogels was Carbopol® 980 of concentrations of 0.5, 0.8, and 1.0 %. The paper aimed to determine the optimal concentration of Carbopol® 980 in hydrogel formulation on the basis of the evaluation of the rheological properties and biological availability of loratadine from prepared hydrogels. The results of the study show 0.5% hydrogel of Carbopol® 980 to be optimal for loratadine from the standpoint of topical administration.

Keywords: hydrogels; Carbopol® 980; loratadine; liberation; rheological properties

Received: March 22, 2004; Accepted: May 26, 2004; Published: March 1, 2005  Show citation

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Capková Z, Vitková Z, Vysokaiová V. Pre-Formulation Studies of the H1-Antihistamine Loratadine for a Topical Dosage Form. Čes. slov. farm. 2005;54(3):109-113.
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    References

    1. Pátek, M.: Čas. čes. lekárníků, 1998; 6, 27.
    2. Gazdík, F, Janek, M.: Slov. Rev., 2000; 10, 68-70. Go to original source...
    3. Urbánek, R.: Remedia, 1993; 3, 216-221.
    4. Chalabala, M., Špringer, V., Čižmárik, J.: Pharma J., 1998; 8, 154-159.
    5. Gispert, J., Antonijoan, R., Barbanoj, M. et al.: Ann. Allerg. Asthma Imm., 2002; 89, 259-264. Go to original source... Go to PubMed...
    6. Ramboer, I., Bumtbacea, R., Lazarescu, D., Radu, R. R.: J. Int. Med. Res., 2000; 28, 69-77. Go to original source... Go to PubMed...
    7. Siergiejko, Z., Chyrek-Borowska, S.: Pol. Tyg. Lek., 1994; 49, 334-336.
    8. Monroe, E. W.: Clin. Ther., 1997; 19, 232-242. Go to original source... Go to PubMed...
    9. Československý liekopis, zväzok I. 4. vyd., Praha, Avicenum, 1987, s. 366-371.
    10. Haake, Betriebsanleitung Viscotester VT 500/VT 501, Germany, 1994, s. 24. Go to original source...
    11. El Ragehy, N. A., Badawey, A. M., El Khateeb, S. Z.: J. Pharm. Biomed. Anal., 2002; 28, 1041-1053. Go to original source... Go to PubMed...
    12. Indrayanto, G., Darmawan, L., Widjaja, S., Noorrizka, G.: J. Plan. Chrom. - Modern TLC, 1999; 12, 261-264.
    13. Slovenský liekopis, zväzok I. 1. vyd., Bratislava, Herba, 1997, s. 74.
    14. Keil, B. et al.: Laboratórní technika biochemie. Praha, ČSA, 1959, s. 303.
    15. Šubová, M., Vitková, Z., Bírová, M.: Zborník abstraktov, 32. konferencia Syntéza a analýza liečiv, Bratislava
    16. -19. 9., s. 91.

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