JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2021, 70(6):206-209 | DOI: 10.5817/CSF2021-6-206

Phenylpropanoids and flavonoid from Helichrysum petiolare Hilliard & B. L. Burtt

Renata Kubínová1,*, Marcela Nejezchlebová3, Markéta Gazdová1, Mária Gáborová1, Ivana Várady2, Lenka Molčanová1
1 Masarykova univerzita, Veterinární a farmaceutická univerzita, Farmaceutická fakulta, Ústav přírodních léčiv, Brno
2 Institut klinické a experimentální medicíny, Praha, Ústavní lékárna
3 Masarykova univerzita Brno, Veterinární a farmaceutická univerzita, Farmaceutická fakulta, Ústav molekulární farmacie

The phytochemical analysis of a methanolic extract from Helichrysum petiolare Hilliard & B. L. (Asteraceae) confirmed the content of phenylpropanoids and flavonoids. Five secondary metabolites were isolated using preparative HPLC, namely coumarin scopolin (

1), 3-chlorogenic acid (

2), caffeic acid-hexose derivative (

3), dicaffeoylquinic acid (

5), and the flavonoid isoquercitrin (

4). These compounds were identified from this species for the first time. Only dicaffeoylquinic acid was able to inhibit Escherichia coli CCM 7929 at the concertation of 512 μg ∙ mL-1 in a screening of antibacterial activity.

Keywords: HPLC; antibacterial activity; Helichrysum petiolare; plant phenols

Received: September 23, 2021; Accepted: November 4, 2021; Published: June 1, 2021  Show citation

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Kubínová R, Nejezchlebová M, Gazdová M, Gáborová M, Várady I, Molčanová L. Phenylpropanoids and flavonoid from Helichrysum petiolare Hilliard & B. L. Burtt. Čes. slov. farm. 2021;70(6):206-209. doi: 10.5817/CSF2021-6-206.
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