Czech and Slovak Pharmacy, 2022 (vol. 71), issue 5

Original Articles

Safety of drug administration from the perspective of hospitalized patients in selected hospitals of the South Bohemia Region

Hana Hajduchová, Iva Brabcová, Radka Prokešová, Valérie Tóthová, Ivana Chloubová, Květoslava Slabáková, Dana Velimská, Edita Klavíková, Hana Kubešová, Martin Doseděl, Josef Malý

Čes. slov. farm. 2022, 71(5):179-189 | DOI: 10.5817/CSF2022-5-179

Drug administration is one of the riskiest areas of healthcare provision, accompanied by several possible mistakes. Patient and family involvement is crucial for patient safety in a hospital environment. The research study aimed to evaluate the subjective perception of the safety of the drug administration process from hospitalized patients' point of view and their involvement in drug administration. A structured questionnaire of its own design was used to obtain data. Three hundred twenty-nine respondents from 4 hospitals in the South Bohemian Region in the Czech Republic were included in the research, including patients hospitalized in the internal...

Formulation and evaluation of novel collagen/carboxymethylcellulose blend film wound dressing

Kateřina Tenorová, Jana Kurfürstová, Ruta Masteiková, Sylvie Pavloková, Jurga Bernatonienė

Čes. slov. farm. 2022, 71(5):190-199 | DOI: 10.5817/CSF2022-5-190

Films are thin, flexible, and transparent wound dressings. They can be prepared from both synthetic and natural materials. In practice, synthetic polyurethane dominates, but research is mainly focused on substances of natural origin. An endogenous substance with excellent filmforming properties, which is involved in the wound healing process, is collagen. However, collagen films themselves have weak mechanical properties, which can be improved by, among other things, combining collagen with other materials. Such material could be carboxymethylcellulose, which has been shown to affect wound healing positively. Films consisting only of CMC also have...

Characteristics of development and dissemination of environmental management systems in the area of production of medicines in Ukraine

Victoria V. Zhurenko, Viacheslav O. Lebedynets

Čes. slov. farm. 2022, 71(5):200-213 | DOI: 10.5817/CSF2022-5-200

The article presents the results of a study based on an expert survey of senior management and leading experts of enterprises for the production of medicines in Ukraine and typical problematic aspects of implementing environmental management systems (EMS). It was found that among the enterprises whose respondents took part in the survey, only 25% implemented EMS and passed the certification procedure following the requirements of ISO 14001. A significant problem identified is the lack of influential information tools and methodological developments for the implementation, operation, and benefits of EMS in pharmaceutical production, especially to ensure...

The effect of non-steroidal anti-inflammatory drugs with different mechanisms of action on the body temperature and cyclooxygenase pathway of the arachidonic acid cascade on the model of acute general cooling (air hypothermia) in rats

Sergiy Shtrygol', Olga Tovchiga, Olesia Kudina, Olga Koiro, Tetiana Yudkevich, Tetiana Gorbach

Čes. slov. farm. 2022, 71(5):214-223 | DOI: 10.5817/CSF2022-5-214

NSAIDs are promising agents for preventing cold injury (frigoprotectors). The influence of prophylactic administration of the non-selective COX inhibitor diclofenac sodium (7 mg/kg) and the highly selective COX-2 inhibitor etoricoxib (5 mg/kg) on cyclooxygenase pathway biomarkers was studied on the model of acute general cooling (air hypothermia at -18 °C for 2 hours). Diclofenac completely prevented a decrease in body temperature, surpassing etoricoxib. In the liver of the rats immediately after cold exposure, the content of COX-1 was increased moderately and the content of COX-2 highly significantly. Very significantly, the level of PGE2 decreased,...

Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico

Sergiy Shtrygol', Sergiy Zalevskyi, Mariia Mishchenko, Diana Shtrygol', Hanna Severina, Wassim El Kayal, Victoriya Georgiyants

Čes. slov. farm. 2022, 71(5):224-233 | DOI: 10.5817/CSF2022-5-224

The anticonvulsant spectrum of the original promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide was studied. The compound had a pronounced anticonvulsant effect, significantly reducing the mortality of mice in models of seizures induced by pentylenetetrazole, picrotoxin, strychnine, and caffeine. In the thiosemicarbazideinduced seizure model, the test compound did not reduce mortality. The obtained results indicated that the mechanism of anticonvulsant action involved GABA-ergic (effective in models of pentylenetetrazole and picrotoxin-induced seizures), glycinergic (efficiency in the strychnine model...