Czech and Slovak Pharmacy, 2022 (vol. 71), issue 3

Original Articles

The effect of Aronia melanocarpa extract on the phospholipid composition of the rat myocardium during stress

Volodymyr Shvets, Hanna Maslak, Vadim Davydov, Halyna Berest, Inna Nosulenko

Čes. slov. farm. 2022, 71(3):98-102 | DOI: 10.5817/CSF2022-3-98

The research was performed on 80 male rats of the Wistar line. Animals of two age groups were used: adults (10-12 months) and old (22-25 months). The obtained data show that the development of immobilization stress in adult and aged rats are accompanied by the formation of a characteristic complex of changes in the phospholipid composition of the myocardium. Intraperitoneal injection of the chokeberry extract (Aronia melanocarpa) at a dose of 0.2 g/kg 60 minutes before the immobilization has limited stress modulation of myocardial phospholipid composition in aged animals. Thus, the extract of Aronia melanocarpa increases the myocardial...

Pulsed electric field energy calculation to damage red galangal (Alpinia purpurata, K. Scumm) rhizome slices and its essential oil yield and quality with hydrodistillation

Sukardi Sukardi, Maimunah Hindun Pulungan, Sang Norma Lintang Asmara

Čes. slov. farm. 2022, 71(3):103-115 | DOI: 10.5817/CSF2022-3-103

This study aimed to determine the amount of energy to damage the red galangal rhizome sliced cell tissue and the amount and quality of the essential oil obtained by steam-water distillation. This study was a randomized block design, with pulsed electric field (PEF) voltage treatment starting at 1000, 2000, 3000, 4000, and 5000 V and without PEF and repeated three times. The results showed that the voltage between 3000 and 4000 V (E = 120-160 V/cm) or equivalent to 271.5-365.0 kJ/cm3 had damaged the red galangal rhizome slice cell tissue. The increase in yield due to PEF ranged from 13% to 73%, and there was no change in the value of the refractive...

Study of possible sex features of ramipril and candesartan treatment under experimental arterial hypertension in rats

Natalia Tsubanova, Alona Kovpak, Igor Zamorskyi

Čes. slov. farm. 2022, 71(3):116-120 | DOI: 10.5817/CSF2022-3-116

The article presents the results of a preclinical study of ramipril and candesartan in an experimental group of hypertensive rats of different sexes. Antihypertensive therapy was performed for 21 days. The drugs were administered daily in moderate therapeutic doses calculated for rats using the coefficient of species sensitivity. It was found that the course of experimental hypertension has gender differences, and in males, according to blood pressure, the level of NO metabolites is more pronounced. The use of ramipril from the group of ACE inhibitors and candesartan from the ARBs group in experimental hypertension in rats has gender differences. Ramipril...

Review articles

Metronomic therapy in the treatment of cancer

Dana Mazánková, Veronika Bárková, Pavel Mazánek

Čes. slov. farm. 2022, 71(3):91-97 | DOI: 10.5817/CSF2022-3-91

Metronomic therapy is a therapeutic method in selected oncological diseases, using long-term administration of low doses of drugs with direct or indirect antitumor effect. In addition, to direct cytotoxic eradication of tumor cells, metronomic therapy can very strongly affect the tumor microenvironment; it also has an immunomodulatory and antiangiogenic effect. Its minimal toxic profile allows for use in patients with severe organ dysfunctions and directly impacts the quality of life and social inclusion of oncological patients.