Antibiotics and the quality indicators for outpatient antibiotic use in Slovakia

Tomáš Tesař, Lucia Masaryková, Slávka Porubcová, Monika Čičová, Miloš Okša, Kristína Malíková, Ľubica Lehocká

Čes. slov. farm. 2021, 70(6):199-205 | DOI: 10.5817/CSF2021-6-199  

The aims of this study was to compare the data on the consumption of antibiotics in the outpatient care sector for Slovakia from 2019 to 2020 and to calculate quality indicators for outpatient antibiotic use. The data source on the consumption of antibiotics (ATC group J01), is the sales data from the NCZI. The main indicator describing the consumption of antibacterials for systemic use is the number of DDDs per 1000 inhabitants per day (DID). The data released by the European Centre for Disease Protection were used as the source for antibiotic consumption for 2019. The most frequently consumed antibacterials for systemic use in the outpatient care...

Phenylpropanoids and flavonoid from Helichrysum petiolare Hilliard & B. L. Burtt

Renata Kubínová, Marcela Nejezchlebová, Markéta Gazdová, Mária Gáborová, Ivana Várady, Lenka Molčanová

Čes. slov. farm. 2021, 70(6):206-209 | DOI: 10.5817/CSF2021-6-206  

The phytochemical analysis of a methanolic extract from Helichrysum petiolare Hilliard & B. L. (Asteraceae) confirmed the content of phenylpropanoids and flavonoids. Five secondary metabolites were isolated using preparative HPLC, namely coumarin scopolin ( 1), 3-chlorogenic acid ( 2), caffeic acid-hexose derivative ( 3), dicaffeoylquinic acid ( 5), and the flavonoid isoquercitrin ( 4). These compounds were identified from this species for the first time. Only dicaffeoylquinic acid was able to inhibit Escherichia coli CCM 7929 at the concertation of 512 μg ∙ mL^-1 in a screening...

Preformulation design of PLGA particulate system for multi-day drug delivery of the antidepressant mirtazapine

Martina Holická, Jan Muselík, Martina Kejdušová, Miroslava Pavelková, Kateřina Kubová, Petr Doležel, David Vetchý, Vratislav Košťál, Jakub Vysloužil, Josef Mašek

Čes. slov. farm. 2021, 70(6):210-219 | DOI: 10.5817/CSF2021-6-210  

In this experimental study, the biodegradable polylactide-co-glycolide (PLGA) microparticles (MP) loaded with the insoluble antidepressant mirtazapine were prepared by the simple o/w solvent evaporation method. The formation involved intrinsic variables, such as the content of polymer (700, 900 or 1200 mg), dichloromethane (5 or 10 ml) and/or drug (200 or 400 or 600 mg), and the volume of the aqueous emulsion phase (400, 600 or 800 ml). The influence of these parameters on the size and morphology of microparticles, encapsulation efficiency, and drug release behavior was observed. All MP were successfully prepared, and their size ranged between 165.34...

Supply of medicines in the Terezín ghetto

Tomáš Arndt, František Dohnal

Čes. slov. farm. 2021, 70(6):220-230 | DOI: 10.5817/CSF2021-6-220  

The article describes the supply and distribution of medicines in the Terezín (Theresienstadt) ghetto (1941-1945). The delivery of medicines for the ghetto took place in several ways. At the beginning of the ghetto's existence, doctors brought the most medicines in their suitcases. Some of the drugs came from incoming prisoners (confiscated). Later, the German doctor Krönert from Litoměřice (Leitmeritz), supplied medicaments. The Prague Jewish community, with the help of a member of the SS Bartels, procured medicines, too. The drugs were also supplied by nearby pharmacies in Roudnice nad Labem and Budyně nad Ohří. At the end of the war, the Red Cross...

XLII. pracovní den Radiofarmaceutické sekce ČSNM

Čes. slov. farm. 2021, 70(6):231-235  

Spomienka na osobnosti farmakognózie

Milan Nagy

Čes. slov. farm. 2021, 70(6):236-237