JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2025, 74(4):272-275 | DOI: 10.36290/csf.2025.044

Topical application of vitamin C and its derivatives in dermatology and cosmetics

Hana Hořavová, Kateřina Brückner
Ústav farmaceutické technologie, Farmaceutická fakulta, Masarykova univerzita, Brno

Vitamin C (ascorbic acid) is a highly valued bioactive substance with extensive use in dermatology and cosmetics. Its main effects are strong antioxidant capacity, collagen synthesis boosting, depigmentation effect and improvement of the skin barrier. Due to these properties, it is a popular ingredient in preparations intended for the prevention of aging and correction of photodamage. Despite its biological efficacy, topical use of vitamin C represents a technological challenge due to its low stability and limited ability to penetrate the skin. The work summarizes the key factors influencing its efficacy - including concentration, pH, formulation and additional stabilizing substances - and presents approaches to improve stability and absorption, including the use of derivatives, excipients or technological processes. The result is a comprehensive overview of the conditions under which effective and safe topical action of vitamin C in cosmetic preparations can be achieved.

Keywords: vitamin C, antioxidant, skin, topical application, ascorbic acid derivatives.

Accepted: November 21, 2025; Published: December 5, 2025  Show citation

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Hořavová H, Brückner K. Topical application of vitamin C and its derivatives in dermatology and cosmetics. Čes. slov. farm. 2025;74(4):272-275. doi: 10.36290/csf.2025.044.
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    References

    1. Global Growth Insights. Vitamin C Market Size & Trends | Global Forecast 2025 2033 [Internet]. Global Growth Insights; c2025 [cited 2025 08 29]. Available from: https://www.globalgrowthinsights.com/market reports/100790.
    2. Cosmetics Business. Vitamin C: The versatile skincare ingredient that still has the power to surprise [Internet]. Cosmetics Business; 2019 [cited 2025 08 29]. Available from: https://www.cosmeticsbusiness.com/vitamin c the versatile skincare ingredient that still has the power to surprise 159853.
    3. Verified Market Reports. Vitamin C Derivatives for Cosmetic Market Size, Trends, Growth & Forecast. Consumer Goods and Retail [Internet]. VERIFIED MARKET REPORTS; c2025 [cited 2025 08 29]. Available from: https://www.verifiedmarketreports.com/product/vitamin c derivatives for cosmetic market/.
    4. Agostoni C, Berni Canani R, Fairweather Tait S, et al. Scientific Opinion on Dietary Reference Values for vitamin C. EFSA J. 2013;11(11):3418. Go to original source...
    5. Colven R M, Pinnell S R. Topical vitamin C in aging. Clin Dermatol. 1996;14(2):227 234. Go to original source... Go to PubMed...
    6. Farris P K. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg. 2005;31(7 Pt 2):814-818. Go to original source... Go to PubMed...
    7. Pullar J M, Carr A C, Vissers M C M. The Roles of Vitamin C in Skin Health. Nutrients. 2017;9(8):866. Go to original source... Go to PubMed...
    8. Pinnell S R, Madey D L. Topical Vitamin C in Skin Care. Aesthet Surg J. 1998;18(6):468 470. Go to original source... Go to PubMed...
    9. Darr D, Combs S, Dunston S, et al. Topical vitamin C protects porcine skin from ultraviolet radiation induced damage. Br J Dermatol. 1992;127(3):247-253. Go to original source... Go to PubMed...
    10. Correia G, Magina A. Efficacy of topical vitamin C in melasma and photoaging: A systematic review. J Cosmet Dermatol. 2023;22(7):1938-1945. Go to original source... Go to PubMed...
    11. Al Niaimi F, Yi Zhen Chiang N. Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. J Clin Aesthet Dermatol. 2017;10(7):14.
    12. Sauermann K, Jaspers S, Koop U, et al. Topically applied vitamin C increases the density of dermal papillae in aged human skin. BMC Dermatol. 2004;4(1):1-6. Go to original source... Go to PubMed...
    13. Taira N, Katsuyama Y, Yoshioka M, et al. 3 O Glyceryl 2 O hexyl ascorbate suppresses melanogenesis by interfering with intracellular melanosome transport and suppressing tyrosinase protein synthesis. J Cosmet Dermatol. 2018;17(6):1209-1215. Go to original source... Go to PubMed...
    14. Caritá A C, Fonseca Santos B, Shultz J D, et al. Vitamin C: One compound, several uses. Advances for delivery, efficiency and stability. NBM. 2020;24:102117. Go to original source... Go to PubMed...
    15. Isoir Ingrez M, Falip A, Yousfi N, et al. Mastering the formulation of an unstable vitamin C (VC) as anti aging skin care ingredient. Part I: A new approach. Int J Cosmet Sci. 2025;47(4):597-603. Go to original source... Go to PubMed...
    16. Zhang L, Lerner S, Rustrum W V, et al. Electroporation mediated topical delivery of vitamin C for cosmetic applications. Bioelectrochem Bioenerg. 1999;48(2):453 461. Go to original source... Go to PubMed...
    17. Enescu C D, Bedford L M, Potts G, et al. A review of topical vitamin C derivatives and their efficacy. J Cosmet Dermatol. 2022;21(6):2349-2359. Go to original source... Go to PubMed...
    18. Napolitano A, Chool Boo Y. Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Anti aging Purposes: Emerging Combination Therapies. Antioxid. 2022;11(9):1663. Go to original source... Go to PubMed...
    19. Sasidharan O, Gholap A, Rastogi R. A Review of Clinical Efficacy of Topical Vitamin C and Its Derivatives. PST. 2023;7(2):20-26. Go to original source...
    20. Yin X, Chen K, Cheng H, et al. Chemical Stability of Ascorbic Acid Integrated into Commercial Products: A Review on Bioactivity and Delivery Technology. Antioxidants. 2022;11(1):153. Go to original source... Go to PubMed...
    21. Shelke O, Susarla K P C, Bankar M. Understand the Stabilization Engineering of Ascorbic Acid, Mapping the Scheme for Stabilization, and Advancement. AAPS Pharm Sci Tech. 2024;25(6):1-10. Go to original source... Go to PubMed...
    22. Gallarate M, Carlotti M E, Trotta M, et al. On the stability of ascorbic acid in emulsified systems for topical and cosmetic use. Int J Pharm. 1999;188(2):233-241. Go to original source... Go to PubMed...
    23. Liston L S, Rivas P L, Sakdiset P, et al. Chemical Permeation Enhancers for Topically Applied Vitamin C and Its Derivatives: A Systematic Review. Cosmetics. 2022;9(4):85. Go to original source...

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