JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2025, 74(3):E8-E11 | DOI: 10.36290/csf.2025.025

Oral ulceration and stomatitis induced by mycophenolate mofetil in a 4-year-old boy after kidney transplantation – a case report

Nikola Halačová1, Miroslava Brndiarová1, Jakub Zieg2, Júlia Kvaššayová1, Alena Szökeová1, 3, Miloš Jeseňák1
1 Klinika detí a dorastu, Jesseniova lekárska fakulta v Martine, Univerzita Komenského v Bratislave, Univerzitná nemocnica v Martine
2 Pediatrická klinika 2. lékařské fakulty UK a Fakultní nemocnice v Motole
3 Ambulancia klinickej farmakológie, Univerzitná nemocnica v Martine

Kidney transplantation is currently considered the optimal and effective treatment for pediatric patients with end-stage kidney disease. Immunosuppressive treatment is essential throughout the entire functioning period of the transplanted kidney to prevent graft rejection. Aphthous stomatitis with painful ulcerations is a common complication among kidney transplant recipients. A rare cause of this condition is the adverse effect of mycophenolate mofetil, which is part of the most common stable triple combination of immunosuppressive drugs. This article presents a case of multiple painful oral ulcerations induced by mycophenolate mofetil in a 4-year-old boy following a related donor kidney transplant. The lesions resolved promptly after discontinuing the medication.

Keywords: oral ulcerations, aphthous stomatitis, mycophenolate mofetil, kidney transplantation

Accepted: September 15, 2025; Published: October 2, 2025  Show citation

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Halačová N, Brndiarová M, Zieg J, Kvaššayová J, Szökeová A, Jeseňák M. Oral ulceration and stomatitis induced by mycophenolate mofetil in a 4-year-old boy after kidney transplantation – a case report. Čes. slov. farm. 2025;74(3):E8-11. doi: 10.36290/csf.2025.025.
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