Čes. slov. farm. 2025, 74(3):188-192 | DOI: 10.36290/csf.2025.032
Interesting pharmacological effects of phenolic acids found in plants
- Katedra farmakognozie a farmaceutické botaniky, Farmaceutická fakulta UK v Hradci Králové
Fenolic acids are present in plants as secondary metabolites and are a common part of the human diet. This is beneficial for the consumer, as their antioxidant activity is known to reduce the risk of neurodegenerative, cardiovascular and oncological diseases. This activity is related to the ability to scavenge free radicals and depends on their structure, especially on the number and positions of hydroxyl groups, as well as the character of substitutions on aromatic rings. Their other significant effects are antiviral, antibacterial, anti-inflammatory and antifungal. Due to the complex of many beneficial effects, they are investigated in more detail preclinical studies (in vitro, ex vivo and in vivo). The aim of this article is to summarize an overview of the most common phenolic acids and their positive effects on human body.
Keywords: plants, phenolic acids, pharmacological effects.
Accepted: September 15, 2025; Published: October 2, 2025 Show citation
References
- Životská I. Faktory ovlivňující kvalitu a množství látek fenolické povahy v rodě Mentha L. Bakalářská práce MENDELU, 2016.
- https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-tilia-cordata-miller-tilia-platyphyllos-scop-tilia-x-vulgaris-heyne-or-their-mixtures-flos-first-version_en.pdf [cit. 6.6.2025].
- Saxena M, Saxena J, Pradhan A. Flavonoids and phenolic acids as antioxidants in plants and human health. Int. J. Pharm. Sci. Rev. Res. 2012;16(2):130.
- Homolová L. Popis a obsahové látky farmaceuticky a toxikologicky významných rostlin. Diplomová práce FaF UK, 2008.
- Harčárová P, Lomozová Z, Kallivretaki M, et al. Different behavior of food-related benzoic acids toward iron and copper. Food Chem. 2025;462:141014.
Go to original source... 
Go to PubMed... - Bílková A. Metodika stanovení hlavních fenolických sloučenin v genotypech jabloní s ohledem na různé podmínky skladování. Výzkumný a šlechtitelský ústav ovocnářský Holovousy s.r.o., 2018.
- Osičková M. Antimikrobiální aktivita extraktu z květu a plodu černého bezu (Sambucus nigra). Diplomová práce MUNI SCI, 2023.
- Laxová L. Biologicky aktivní fenolické látky v drobném ovoci. Diplomová práce JCU, 2017.
- Fadrhoncová P. Antioxidanty v bylinných čajích. Diplomová práce MENDELU, 2015.
- Pourová J, Najmanová I, Vopršalová M et al. Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo. Vasc. Pharmacol. 2019;111:36-43. Go to original source... Go to PubMed...
- Kumar N, Goel N. Phenolic acids: Natural versatile molecules with promising therapeutic applications. Biotech. Rep. 2019, 24. Go to original source... Go to PubMed...
- Sarker U, Oba S. Antioxidant constituents of three selected red and green color Amaranthus leafy vegetable. Sci. Rep. 2019;9:18233. Go to original source... Go to PubMed...
- Fursenco C, Calalb T, Uncu L, et al. A review of its ethnomedicinal uses, phytochemistry, and pharmacological activities. Biomolecules 2020;10:1619. Go to original source... Go to PubMed...
- Elansary HO, Szopa A, Klimek‑Szczykutowicz M, et al. Mammillaria species-polyphenols studies and anti‑cancer, anti‑oxidant, and anti‑bacterial activities. Molecules 2020, 25:131. Go to original source... Go to PubMed...
- Jiang X, Liu Y, Li W, et al. Tissue-specific, development-dependent phenolic compounds accumulation profile and gene expression pattern in tea plant [Camellia sinensis]. PLoS One, 2013, 8(4): e62315. Go to original source... Go to PubMed...
- Graja Z. Přírodní látky a jejich biologická aktivita VIII. Antioxidační aktivita obsahových látek nati Rhodiola rosea L. Rigorózní práce FaF UK, 2021.
- Lachman J, Hamouz K, Orsák M. Červeně a modře zbarvené brambory - významný zdroj antioxidantů v lidské výživě. Chem. Listy 2005, 99: 474-482.
- Karlíčková J, Klížová A. Rosemary - its biologically active compounds and their pharmacological effects. Čes. slov. farm. 2024;73(1):42-46. Go to original source... Go to PubMed...
- Brancová P. Syntéza derivátů kyseliny kávové a jejich toxicita. Diplomová práce. MU SCI, 2008.
- Habtemariam S. Molecular pharmacology of rosmarinic and salvianolic acids: potential seeds for Alzheimer´s and vascular dementia drugs. Int. J. Mol. Sci. 2018;19 (2):458. Go to original source... Go to PubMed...
- Gricová M. Faktory ovlivňující množství a kvalitu silice v rodu Origanum L. (dobromysl). Bakalářská práce, MENDELU 2017.
- Alam N, Hossain M, Khalil MI, et al. High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis. BMC Comp. Alt. Med. 2011,11:65. Go to original source... Go to PubMed...
- https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-althaea-officinalis-l-radix_en.pdf [cit. 6.6.2025]
- Stepanova SI, Boynik VV. Fenolové kyseliny a antioxidační potenciál výhonků Caragana frutex. Čes. slov. farm. 2021;70(3):112-115. Go to original source...
- https://vuzv.cz/wp-content/uploads/2018/03/Mykotoxiny-studie-2012-1.pdf [cit. 6.6.2025]
- Ferreira-Santos P, Genisheva Z, Botelho C, et al. Unravelling the Biological Potential of Pinus pinaster Bark Extracts. Antioxidants (Basel) 2020;20(4):334. Go to original source... Go to PubMed...
- Kumar N, Goel N. Phenolic acids: Natural versatile molecules with promising therapeutic applications. Biotechnol. Rep. 2019;24:e00370.Další literatura u autorky. Go to original source... Go to PubMed...