Již 155 let pomáháme rozvíjet farmacii

prof. PharmDr. Martin Doležal, Ph.D.

Čes. slov. farm. 2026, 75(1):3

Idiopathic interstitial lung diseases - treatment options

Martina Šterclová

Čes. slov. farm. 2026, 75(1):8-13 | DOI: 10.36290/csf.2026.003

Idiopathic interstitial pneumonias (IIPs) represent a heterogeneous group of rare lung diseases characterized by distinct radiological and histological phenotypes. The new 2025 classification provides a more detailed definition of individual entities, including the incorporation of idiopathic eosinophilic pneumonias and rare forms, without yet altering current therapeutic approaches. The most common form is idiopathic pulmonary fibrosis (IPF), where antifibrotic therapy with pirfenidone and nintedanib has been shown to improve prognosis. Recent clinical trials (FIBRONEER, TETON) suggest further therapeutic options. The treatment of other IIPs, particularly...

Drug unavailability increases off-label prescribing in the pediatric population in Slovakia

Michala Hrončová, Simona Valášková, Andrea Gažová

Čes. slov. farm. 2026, 75(1):E12-E18 | DOI: 10.36290/csf.2026.010

Drug shortages may lead to interruption of ongoing treatment, delays in therapy initiation, or the need to modify therapeutic regimens. This represents a current and persistent problem that requires systematic and long-term solutions, as it may be a significant contributing factor to off-label prescribing. Between 2018 and 2020, the occurrence of drug shortages increased up to twentyfold, accompanied by a growing demand for essential medicines. The aim of this study was to analyse the occurrence of off-label prescribing in the paediatric population in a community pharmacy and to assess a possible association between the unavailability of a selected...

Syntéza a antimikrobiální vlastnosti derivátů 2-[(7-ethyl-3-methylxanthin-8-yl)sulfanyl]acetohydrazidu

Dmytro Ivanchenko, Mykola Romanenko, Olha Pakhomova, Oleksandra Cherchesova, Natalia Rudko, Natalia Voronova, Horban Valerii

Čes. slov. farm. 2026, 75(1):E20-E26 | DOI: 10.36290/csf.2026.011

Antimikrobiální rezistence (AMR) představuje zásadní globální zdravotní hrozbu, která podněcuje naléhavé hledání nových terapeutických látek. Hybridní molekuly založené na xanthinových a 1,2,4-triazolových skeletech představují slibný směr díky svým potenciálním multitargetovým antimikrobiálním účinkům. Tato studie měla za cíl syntetizovat nové deriváty 2-[(7-ethyl-3-methylxanthin-8-yl)sulfanyl]acetohydrazidu obsahující 1,2,4-triazolové zbytky, charakterizovat jejich struktury a vyhodnotit jejich antimikrobiální a protiplísňové vlastnosti. Byla syntetizována řada dosud nepopsaných sloučenin za použití N-substituovaných isothiokyanátů a následných...

Pharmacokinetic changes and approach to drug dosing in patients with obesity and after bariatric surgery

Alena Pilková

Čes. slov. farm. 2026, 75(1):16-23 | DOI: 10.36290/csf.2026.004

Introduction: Obesity is a chronic disease associated with multiple comorbidities and can affect drug pharmacokinetics. Appropriate dosing in obese patients is essential to ensure therapeutic efficacy and safety. Objective: To summarize the impact of obesity and bariatric surgery on drug pharmacokinetics and provide recommendations for individualized dosing. Methods: Review of available literature and clinical guidelines addressing changes in drug absorption, distribution, metabo­lism, and excretion in obese patients and after bariatric procedures. Results: Obesity is associated with nonlinear changes in volume of distribution and heterogenous changes...

Artificial intelligence in pharmacy services - practical applications

Milan Rydrych

Čes. slov. farm. 2026, 75(1):24-29 | DOI: 10.36290/csf.2026.005

Introduction: Paper presents the principles of modern artificial intelligence (AI), its current capabilities, limitations, and practical applications in pharmacy. The text outlines the development of AI, explains key terms, and introduces the most important models and their capabilities. Objective: The objective of the article is to show how AI can support pharmaceutical practice, where its limits lie, and what legislative and safety requirements must be respected when using it. Results: Modern AI models enable text generation, data processing, image analysis, and decision support. In pharmacy, they can speed up data analysis (e.g., LEK-13 reports),...

Effective communication in the pharmacy

Pavel Novák

Čes. slov. farm. 2026, 75(1):30-33 | DOI: 10.36290/csf.2026.006

The text summarizes the principles of effective communication in pharmacy practice and emphasizes its key role in ensuring the safe and high-quality provision of pharmaceutical services. The introduction provides a detailed description of verbal, paraverbal, and nonverbal communication elements, including their interaction in everyday patient interactions. The text further describes internal and external communication barriers that may disrupt or hinder information exchange. Significant attention is given to empathy and active listening, which enable pharmacists to better understand the needs, concerns, and expectations of patients. Active listening...

Pelargonium sidoides DC. vs. Pelargonium reniforme (Andrews) Curtis -active constituents and medicinal effects

Zdeňka Navrátilová

Čes. slov. farm. 2026, 75(1):35-41 | DOI: 10.36290/csf.2026.007

Pelargonium sidoides and Pelargonium reniforme are two closely related species of geraniums growing in Southern Africa. The species belong to the section Reniformia and are morphologically quite similar and often confused. Both species are used for medicinal purposes, but differ in the representation of the compounds and pharmacological effects. The article summarizes information about their composition and medicinal effects and compare it.

Sinusitis self-treatment

Tomáš Hammer

Čes. slov. farm. 2026, 75(1):42-47 | DOI: 10.36290/csf.2026.008

Inflammation of the paranasal sinuses is a common respiratory tract disease and a frequent reason for visiting the pharmacy. In most cases, acute sinusitis is of viral origin, treatment is aimed at alleviating symptoms and does not require physician intervention. The article briefly summarizes the groups of over-the-counter products suitable for self-treatment of acute sinusitis, their use and limitations, complementary non-pharmacological measures, and situations where self-treatment is no longer sufficient.

Ocular manifestations of allergies - options for self-treatment

Martina Čudová, Jana Melicharová, Tereza Kauerová

Čes. slov. farm. 2026, 75(1):48-53 | DOI: 10.36290/csf.2026.009

Ocular allergies, the majority of which are seasonal allergic conjunctivitis, are one of the most common ocular conditions for which patients seek professional help. These allergies mainly affect the structures of the anterior segment of the eye, including the conjunctiva, cornea, eyelids, or lacrimal glands. Patients may experience a range of symptoms, from mild to severe, and in some cases, chronic forms of the condition can lead to gradual vision impairment. Currently, several over-the-counter medications containing antihistamines, mast cell stabilizers, and decongestants are available for the treatment of ocular allergies, when used in combination...

Skin hydration: How to increase the water content in the skin with dermocosmetics?

Andrej Kováčik, Barbora Vraníková, Robert Čáp

Čes. slov. farm. 2026, 75(1):E8-E11 | DOI: 10.36290/csf.2026.002

The ability of skin to retain water and its hydration are essential for both the appearance and function of the skin barrier. Dry skin occurs when natural hydration mechanisms are impaired, accompanied by a loss of elasticity, scaling and an unpleasant feeling of tightness. The aim of this article is to explain the mechanisms of skin hydration and describe the properties of moisturizing cosmetic products. The article discusses the mechanisms of action and examples of cosmetic humectants, emollients, and occlusives that prevent transepidermal water loss. Moisturizing cosmetics containing these ingredients are therefore essential for restoring and maintaining...

Where did history of the pharmacy go?

Sixtus Bolom-Kotari, Jindřich Kolda

Čes. slov. farm. 2026, 75(1):E2-E7 | DOI: 10.36290/csf.2026.001

The text is based on the authors' paper at this year's LXXth Symposium on the History of Pharmacy (24/05/2025, Kuks) and summarizes their arguments as to why contemporary Czech pharmaceutical historiography is in an attenuation (decline?) and what are the possible paths to its re-flourishing. The authors see the cause of this situation in an overly narrow conception of the field, focused exclusively on strictly pharmaceutical matters, further in a certain preference for pharmaceutical education as a prerequisite for research into the history of the field and, last but not least, a impression that the picture of the history of pharmacy is already more...

Střípky z XXVII. sympozia klinické farmacie René Macha

Kateřina Zyková, Markéta Dresslerová, Eliška Kolmanová

Čes. slov. farm. 2026, 75(1):55-60

Fixní kombinace antihypertenziv, adherence a rizika záměny v klinické praxi

PharmDr. Josef Suchopár, Mgr. Štěpán Suchopár

Čes. slov. farm. 2026, 75(1):62-64