Medical and non-medical costs of Parkinson disease - comparison of Europe, USA, Asia an Australia

Petra Marešová, Blanka Klímová, Kamil Kuča

Čes. slov. farm. 2017, 66(1):3-8 | DOI: 10.36290/csf.2017.001  

At present different kinds of dementia impose a significant economic burden on the whole societies. Parkinson's disease is the second most common type of dementia. The purpose of this study is to analyze the costs of people suffering from Parkinson's disease in the context of public expenditure needs for the affected people. Firstly, the treatment costs and care in the selected European countries are analyzed, and secondly, these data are compared with the data from other countries and continents. The focus is not only on the developed economies where the issue of costs and PD already causes significant expenditure from public budgets, but also on...

Gas chromatography - mass spectrometry studies of the component composition of carboxylic acids of the rhizomes of Iris medwedewii and Iris carthaliniae (Iridaceae)

Javanshir I. Isayev, Оlga O. Mykhailenko, Vladumir M. Kovalyov, Gamid M. Gurbanov, Murad Y. Suleymanov

Čes. slov. farm. 2017, 66(1):9-14 | DOI: 10.36290/csf.2017.002  

The composition of carboxylic acids of the rhizomes of Iris carthaliniae and Iris medwedewii by the gas chromatography - mass spectrometry method has been studied for the first time. The total content of carboxylic acids for I. carthaliniae was 1.34%, including (%) - 0.65 fatty; 0.36 mono-, di- and tri-carboxylic; 0.33 phenol carboxylic acids. The yield of carboxylic acids for I. medwedewii was 1.58%, including (%) - 0.73 fatty; 0.38 mono-, di- and tri-carboxylic; 0.47 phenol carboxylic acids. The dominant fatty acids in the rhizomes of I. carthaliniae were myristic acid (25%), palmitic acid (14.41%), stearic acid...

Cytotoxic, anti-cancer, and anti-microbial effects of different extracts obtained from Artemisia rupestris

Shamshabanu Nokerbek, Zuriyadda Sakipova, Marta Chalupová, Marcela Nejezchlebová, Jan Hošek

Čes. slov. farm. 2017, 66(1):15-22 | DOI: 10.36290/csf.2017.003  

Artemisia rupestris is a part of traditional Kazakh folk medicine. Extracts obtained from this plant are used to treat various diseases, including cancer. This study evaluates the anti-microbial, cytotoxic, and anti-cancer effects of different extracts of the plant. Different extraction techniques were used and the resultant activities were compared. Extracts of A. rupestris were prepared from the flowers plus the leaves and from the stems. The antimicrobial activity against Candida albicans and Staphylococcus aureus was quantified. Cell lines L1210 and THP-1 were used to evaluate the cytotoxic potential of these extracts...

Self-emulsifying drug delivery system (SEDDS) of Ibuprofen: formulation, in vitro and in vivo evaluation

Subhash Chandra Bose Penjuri, Saritha Damineni, Nagaraju Ravouru, Srikanth Reddy Poreddy

Čes. slov. farm. 2017, 66(1):23-34 | DOI: 10.36290/csf.2017.004  

The goal of the present study was to develop a self-emulsifying drug delivery system for the oral poorly water-soluble drug ibuprofen and to evaluate its oral bioavailability. Phase diagrams were constructed to determine the phase behaviour of the microemulsions and to compare the efficiency of various surfactant-oil mixtures. The SEDDS formulations of ibuprofen were prepared from a mixture of Labrafil M2125, Cremophor RH40, and Plurol oleique. The prepared emulsions were characterized for in vitro and in vivo behaviour. A FTIR study confirmed there is no interaction between the drug and excipients. DSC studies showed that the drug is...

The fate of Jewish pharmacists from the Czech Lands during the holocaust

Tomáš Arndt, František Dohnal

Čes. slov. farm. 2017, 66(1):35-45 | DOI: 10.36290/csf.2017.005  

The authors describe the lives of several Jewish pharmacists and their families who lived and worked in the Czech Lands during the years 1918-1945. Their stories represented a typical mosaic, which corresponds to the fate of the Jewish community in the Czech Lands during World War II - all lost their property and the majority of them were murdered or lost their immediate families. Only a few of them succeeded to survive thanks to early emigration. Some of them lived until the liberation of the concentration camp Theresienstadt, too.

Sympozia Sekce dějin farmacie ČFS v roce 2016

Čes. slov. farm. 2017, 66(1):46-52