JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2015, 64(4):144-148 | DOI: 10.36290/csf.2015.031

Study of local anaesthetics: Part 206. Micellization of selected of quaternary ammonium salt derived from heptacaine

Jana Gališinová, Jozef Čižmárik, Eva Salanci, Andrea Gálusová, Lenka Stopková, Fils Andriamainty*
Farmaceutická fakulta UK, Katedra farmaceutickej chémie, Bratislava, SR

Micellization of selected quaternary ammonium compounds derived from heptacaine have been studied by absorption spectroscopy in the UV/VIS spectral region with the use of a pyrene probe. The compounds studied in the aqueous solution have been marked as H22, H26, H27, H29, H34, H + Al and H + B and the derivative marked as H34 was studied in a 3 mol/l ethanol solution at the temperature of 25 °C. In the homologous series of the studied bromides H22, H26, H27 and H29, cmc was observed to be dependent on the number of carbon atoms nC in the hydrophobic chain: ln (cmc) = -3.131-0.421nC. The Free Gibbs energy necessary for the transfer of a methyl group of the alkyl chain from the water phase to the inner part of the micelle at the temperature of 25 °C is (-0.421 ± 0.034)RT.

Keywords: heptacaine; quaternary ammonium compounds; critical micelle concentration; pyrene; Boltzmann-sigmoidal equation; alcohol

Received: June 8, 2015; Accepted: June 25, 2015; Published: April 1, 2015  Show citation

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Gališinová J, Čižmárik J, Salanci E, Gálusová A, Stopková L, Andriamainty F. Study of local anaesthetics: Part 206. Micellization of selected of quaternary ammonium salt derived from heptacaine. Čes. slov. farm. 2015;64(4):144-148. doi: 10.36290/csf.2015.031.
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