JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 2009, 58(3):95-102

Review of hydroxamic matrix metalloproteinase inhibitors and their therapeutic potential

J. ©ille*, V. Garaj, M. ©ramko, M. Remko
Univerzita Komenského Bratislava, Farmaceutická fakulta, Katedra farmaceutickej chémie, SR

The hydroxamic acid moiety is the key structural element for the potency of the inhibitors against metalloprotease enzymes. However, the selectivity of the inhibitors towards various metalloproteases depends on the structures of the templates or scaffolds as well as the variations of the substituents. A combination of the traditional substrate- and mechanism-based approaches and the new technologies, such as the structural-based drug design as well as combinatorial chemistry, will be essential for the future development of specific protease inhibitors. Success in a clinical trial of new hydroxamic acid-based inhibitors is expected soon.

Keywords: hydroxamates; MMP; TACE; metalloenzymes; metalloproteinases
Grants and funding:

Táto práca bola vytvorená s podporou grantu Ministerstva ąkolstva SR (č. grantu 1/4301/07).

Received: April 14, 2009; Accepted: May 5, 2009; Published: March 1, 2009  Show citation

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©ille J, Garaj V, ©ramko M, Remko M. Review of hydroxamic matrix metalloproteinase inhibitors and their therapeutic potential. Čes. slov. farm. 2009;58(3):95-102.
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