A clinical study of the relationship of selenium plasma level to atopic dermatitis, a comparison of the results of determination using the methods of galvanostatic dissolution chronopotentiometry and atomic absorption spectrometry

A. Planková, P. Mikuš, E. Havránek

Čes. slov. farm. 2009, 58(3):109-115  

In the human organism, the external factors of the environment, smoking and stress provoke the production of very reactive free particles - radicals. In the case of deficiency of suitable protective mechanisms in the organism, these reactive particles produce the conditions for the development of inflammatory diseases in the body. The human body possesses protective mechanisms of its own to defend the organisms against free radicals. From this viewpoint, particularly antioxidants, i.e. substances capable to neutralize free radicals, are of increased importance. One of the antioxidants of key importance is the nutritional element selenium, the importance...

Formulation of chlorhexidin into gels

Z. Vitková, P. Herdová, M. Šubová, V. Šimunková

Čes. slov. farm. 2009, 58(3):116-118  

The paper deals with the selection of optimal auxiliary substances from the group of enhancers and humectants for the formulation of chlorhexidin into the dosage form chitosan hydrogel. The concentrations of the active ingredient and the gel-producing substance are always constant, 0.1% (m/m) and 2.5% (m/m), respectively. The active ingredient chlorhexidin is one of the most widely used antiseptic agents to treat the inflammations of the oral cavity. The paper evaluated its release from hydrogels without and with Polysorbat 80 in 0.1 and 0.5% (m/m) and glycerol in 10% (m/m). The content of the active ingredients was determined spectrophotometrically,...

Implementation of radio-frequency identification (RFID) in the process of preparation and administration of drugs

Š. Kozáková, V. Pechmann, R. Goněc, L. Doležalová, J. Štumpf, J. Rydval

Čes. slov. farm. 2009, 58(3):119-124  

The RFID project is focused on a multidisciplinary part of the healthcare system: the use of cytotoxic drugs with a risk of cancerogenity and mutagenity in a process of oncological patient healthcare. Implementation of RFID technology means higher safety of preparation and administration of chemotherapy with respect both to the patient and personnel. RFID technology enables multiple and retrospective control of the constitution of preparation. RFID technology implementation will result in minimization of the professional failure during preparation and administration of chemotherapy. Successful running of RFID technology demands the integration of the...

Review of hydroxamic matrix metalloproteinase inhibitors and their therapeutic potential

J. Šille, V. Garaj, M. Šramko, M. Remko

Čes. slov. farm. 2009, 58(3):95-102  

The hydroxamic acid moiety is the key structural element for the potency of the inhibitors against metalloprotease enzymes. However, the selectivity of the inhibitors towards various metalloproteases depends on the structures of the templates or scaffolds as well as the variations of the substituents. A combination of the traditional substrate- and mechanism-based approaches and the new technologies, such as the structural-based drug design as well as combinatorial chemistry, will be essential for the future development of specific protease inhibitors. Success in a clinical trial of new hydroxamic acid-based inhibitors is expected soon.

A short introduction to algal and cyanobacterial constituents - the occurrence of phenolic metabolites

J. Vacek, M. Šnóblová, B. Klejdus

Čes. slov. farm. 2009, 58(3):103-108  

Algae and cyanobacteria belong to photosynthetic organisms responsible for primary production of the Earth. Algae are able to synthesize different compounds (phycocolloids and low-molecular metabolites, such as vitamins, glycosides, toxins, and photosynthetic pigments) which are applied and tested in biotechnology, pharmacy, and food industry. Many of algal metabolites are antioxidants and/or antimicrobial agents and therefore the application of these metabolites in pharmaceutical and biomedical research and development is discussed. In the present review, the compounds important for chemical industry and basic algal phenolic metabolites are described.

Ointments in medieval Europe

P. Drábek

Čes. slov. farm. 2009, 58(3):125-128  

Being based primarily on Czech literary sources, the paper deals with the ointments used in European countries in the Middle Ages. It deals with the terminology, raw materials and technologies of ointment formulation, and discusses some interesting sorts of ointments and their development.

Nové knihy

Čes. slov. farm. 2009, 58(3):115  

XXXI. pracovní dny sekce radiofarmacie české společnosti nukleární medicíny ČLS JEP

Čes. slov. farm. 2009, 58(3):129-137  

Pracovní den sekce přírodních léčiv české farmaceutické společnosti ČLS JEP

Čes. slov. farm. 2009, 58(3):138-140  

Ze zasedání Rady EUFEPS 2009

P. Komárek

Čes. slov. farm. 2009, 58(3):141-142