Čes. slov. farm. 2008, 57(4):170-176

A study of the properties of tablets from two types of directly compressible xylitol

J. Mužíková, H. Komínková

Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Technology

The paper deals with the study of tensile strength and disintegration time of tablets from two types of directly compressible xylitol, Xylitab 100 and Xylitab 200, in dependence on compression force, addition of two types of lubricants in one concentration, and two types of active ingredients. Tablets were compressed using the compression forces of 6, 8, and 10 kN, in the case of tableting materials with active ingredients, only 10 kN. The lubricants employed were magnesium stearate and sodium stearyl fumarate at the concentration of 1%, the active ingredients, ascorbic acid and acetylsalicylic acid at the concentration of 50%. The strength of tablets increased with compression force. Compacts from Xylitab 100 possessed a higher strength and it was more decreased by added lubricants than compacts from Xylitab 200, in which, in contrast to Xylitab 100, magnesium stearate decreased strength more. Disintegration time was longer in the case of compacts with Xylitab 200; it increased with compression force, except in those with Xylitab 200 with magnesium stearate and it was prolonged in the case of the presence of lubricants, more in the case of magnesium stearate . Compacts with both active ingredients were stronger and possessed a shorter disintegration time in the case of Xylitab 100. A significantly higher strength and a longer disintegration time was observed in the tablets with acetylsalicylic acid.

Keywords: Xylitab 100; Xylitab 200; lubricants; tensile strength of tablets; time of disintegration

Grants and funding:

The study was supported by the grant MSM 0021620822 and by the firm Danisco, which supplied the samples of the dry binders tested.

Received: June 27, 2024; Accepted: July 2, 2008; Published: April 1, 2008  Show citation