Čes. slov. farm. 2007, 56(2):67-72

Pellets preparation by the drug layering technique in a rotary processor

M. Švarcová, D. Vetchý

Farmaceutická fakulta, Veterinární a Farmaceutická Univerzita Brno, Ústav technologie léků

Pelletization by the layering technique can be carried out by applying a liquid (a drug solution or suspension) or a drug powder using either coating drums or a fluidized bed equipment. This technique is used particularly for the formulation of multiparticulate controlled release dosage forms. Application of a drug on inactive beads in a centrifugal fluid-bed equipment (a rotary processor) represents the up-to-date technique of pellets production. Pelletization by the tangential drug-layering process is a multivariate process, and it is important to identify as well as to control the process variables and conditions. The goal of this paper is to give a summary about one of the newest pelletizing technologies - drug layering in a rotary processor, to outline its possibilities, and particularly to describe the influence of formulation and process parameters on the properties of the final product.

Keywords: pellets; powder layering; suspension and solution layering; rotoprocessor

Received: February 1, 2007; Accepted: February 20, 2007; Published: February 1, 2007  Show citation