Čes. slov. farm. 2005, 54(2):86-89
Use of Capillary Isotachophoresis for the Determination o Pheniramine in Granulated Powders
- Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra farmaceutickej analýzy a nukleárnej farmácie
The method of capillary isotachophoresis was used to assay pheniramine in granulated powders. Several electrolyte systems of different composition and different pH were tested. Two electrolyte systems were selected for the validation of the method and pheniramine determination in real samples. Precision, accuracy, linearity, robustness, and selectivity of the ITP method for both electrolyte systems were evaluated. The pre-treatment of samples prior to analysis consisted in dissolving pheniramine-containing granulated powder in demineralized water and subsequent diluting with demineralized water to required concentration.
Keywords: isotachophoresis; pheniramine; drug; granulated powders; validation
Received: April 1, 2004; Accepted: May 8, 2004; Published: February 1, 2005 Show citation
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