JOURNAL OF THE CZECH PHARMACEUTICAL SOCIETY AND THE SLOVAK PHARMACEUTICAL SOCIETY

Čes. slov. farm. 1999, 48(5):233-236

Preparation of Hydrazones of R- and S-usnic Acid Their Antitumor Activity

B. Proksa, A. Proksová
Slovakofarma, a. s., Hlohovec

Hydrazones of R- and S-usnic acid were prepared by condensation of the appropriate enantiomer ofusnic acid with hydrazides of aromatic acids. Prepared compounds were characterized by spectral methods. Reaction kinetic was studied with capillary electrokinetic chromatography, enantiomeric purity of products was checked by capillary electrophoresis in the presence of g-cyclodextrin. Obtained hydrazones were tested as prospective antimitotic agents. The antitumor activity was screened in vitro on human tumor cell lines. The overall activity of tested compounds was low, however, the R-enantiomers were more active than their opposite stereoisomers.

Keywords: R-, S-usnic acid; hydrazones; MEKC; antimitotic activity; antitumor activity

Published: May 1, 1999  Show citation

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Proksa B, Proksová A. Preparation of Hydrazones of R- and S-usnic Acid Their Antitumor Activity. Čes. slov. farm. 1999;48(5):233-236.
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