Čes. slov. farm. 2005, 54(2):96-99
Effect of Polymer Concentration on Rheological Properties of Carbopol® 980 Hydrogels Containing Trimecainium Chloride
- 1 Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra galenickej farmácie
- 2 SZTE Gyógyszertechnológiai Intézet, Szeged, Maďarsko
Rheological properties exert influence on the manufacturing processes, stability and usability of a dosage form as well as the biological availability of an active ingredient. The present paper examines the effect of Carbopol® 980 concentration on rheological properties of hydrogels with and without trimecainium chloride for a period of 2, 7, and 14 days after their preparation. On the basis of an evaluation of the changes in structural viscosity in dependence on the period of measurement, it has been concluded that for formulation of trimecainium chloride to a dermal dosage form, Carbopol® 980 concentrations of 0.5 and 1.2 % are suitable.
Keywords: Carbopol® 980; trimecainium chloride; hydrogels; rheological properties
Received: April 6, 2004; Accepted: June 25, 2004; Published: February 1, 2005 Show citation
References
- Stankovičová, T., Nemček, V., ©tolc, S.: Čes. a Slov. Farm., 1995; 5, 265-267.
- Ebel, S., Roth, H. J.: Lexikon der Pharmazie, Georg Theime Verlag Stuttgart, New York, 1987, s. 525.
- Bernkop-Schnuerch, A., Valenta, C.: Sci. Pharm., 1995; 63, 65-70.
- Csanyi, E., Erös, I., Blum, A.: Farm. Vestn., 1997; 48, 352-353.
- Owen, D. H., Peters, J. J., Katz, D. F.: Contraception, 2000, 2001; 62, 321-326.
Go to original source... 
Go to PubMed... - Fang, J. Y., Chen, S. S., Wu, P. C., Tsai, Y. H.: Pharmazie, 1999; 54, 154-155. Go to original source...
- Český lékopis, 1. vyd., Praha, Grada Publishing, 1997.
- USP Dictionary of USAN and International Drug Names, United States Pharmacoieal Convention, Twinbrook Parkway, Rockwille, 1996, s.125-126.
- Firemná literatúra BF Goodrich Company, Bulletin 2, Cleveland, Ohio, 1994.