Doktorské studium na Farmaceutické fakultě UK v Hradci Králové: cesta k vědě, která má smysl

prof. PharmDr. František Štaud, Ph.D.

Čes. slov. farm. 2025, 74(2):79

Current trends in insulin therapy

Kateřina Štechová

Čes. slov. farm. 2025, 74(2):84-89 | DOI: 10.36290/csf.2025.011

In January 2025, 103 years have passed since the injection of insulin saved the life of the first patient with type 1 diabetes mellitus. The aim of the article is to familiarize readers with current insulin therapy, which is an essential treatment modality for patients with type 1 diabetes, but also for many patients with other types of diabetes mellitus. The current treatment of patients with type 1 diabetes consists of using 2^nd generation insulin analogues, either rapid in insulin pumps, which now also have the so-called hybrid closed-loop function, or patients apply a rapid analogue in combination with a basal analogue by insulin pens....

Current pharmacotheraupeutical options of lower urinary tract symptoms

Marcela Fontana

Čes. slov. farm. 2025, 74(2):90-93 | DOI: 10.36290/csf.2025.012

Lower urinary tract symptoms (LUTS) represent a wide unit with multifactorial etiology, and therefore, treatment is not uniform. In most patients with LUTS, pharmacotherapy is an effective option for managing these symptoms, thereby improving the quality of life. We have medications from various drug classes available, which can be effectively combined to achieve the best therapeutic outcome. The following text provides an overview of the current pharmacotherapy for LUTS.nce-based medicine principles are essential when searching for and critically evaluating information use in pregnancy.

Proposal of limit values for surface contamination by cytotoxic drugs in pharmacies and hospitals

Lenka Doležalová, Lucie Bláhová, Jan Kuta, Tereza Hojdarová, Luděk Bláha

Čes. slov. farm. 2025, 74(2):96-102 | DOI: 10.36290/csf.2025.013

Introduction: Cytotoxic drugs (cytostatics), widely used in the treatment of not only cancer diseases, are substances with potentially dangerous properties for healthcare personnel. Long-term daily exposure to cytostatics is associated with the possible manifestation of their genotoxic, carcinogenic and teratogenic effects. Handling of these drugs (during receipt, storage, preparation, packaging, transport, administration) can lead to contamination of the workplace and thus to exposure of healthcare personnel present. Objective: The aim of our work was to propose, based on previous results and experience gained from long-term monitoring, a limit threshold...

Anticonvulsant biotargets of digoxin: in silico study and in vivo verification

Vadym Tsyvunin, Hanna Severina, Sergii Shtrygol’, Victoriya Georgiyants, Diana Shtrygol’

Čes. slov. farm. 2025, 74(2):E1-E8 | DOI: 10.36290/csf.2025.021

One of the promising ways to control multidrug-resistant epilepsy may be to use, in addition to traditional antiepileptic drugs (AEDs), medicines from other pharmacological groups – the so-called „non-antiepileptic” drugs. Among such drugs, the cardiac glycoside digoxin deserves special attention. It was established that sub-cardiotonic doses of digoxin exhibit both their own anticonvulsant effect and have been shown to enhance the anticonvulsant potential of classical AEDs. However, the mechanisms of this action and the probable cerebral biotargets with which these properties of digoxin may be associated, remain completely unknown....

The management of vulvovaginal candidiasis: the results of survey in Lviv, Ukraine

Oksana Horodnycha, Tetiana Ryvak, Oksana Nepyivoda

Čes. slov. farm. 2025, 74(2):E10-E15 | DOI: 10.36290/csf.2025.022

Vulvovaginal candidiasis (VVC) is a serious clinical and social issue. The questionnaire-based study was performed to assess the management of VVC in Lviv, Ukraine. Totally 408 women were enrolled in the survey. The lifetime prevalence of VVC was high (72.6 %). 35.8 % of women had VVC during the last year with the predominance of 1 episode (72.6 %). The most common symptoms were vaginal itching and cottage cheese-like vaginal discharge, affecting 89.7 % and 71.7 % of women with VVC, respectively. Stress (57.2 %) was the main self-reported factor associated with the VVC, followed by antibiotic therapy (49.7 %)....

CAR-T therapy - the role of the pharmacist

Marcela Heislerová

Čes. slov. farm. 2025, 74(2):103-107 | DOI: 10.36290/csf.2025.014

CAR-T therapy uses and advances the ability of the human immune system to attack tumor cells. It can currently only be administered in specialized treatment centers in the Czech Republic, which must be able to ensure the collection of T lymphocytes, their sending for preparation, the subsequent administration of CAR-T preparations, as well as the recognition, monitoring and management of possible adverse effects of the treatment (1). The aim of this article is to highlight the role of hospital pharmacists, who are key to the correct handling of these highly specialized preparations. Due to the difficulty of handling and the high price of these preparations,...

Resources and drug information on pharmacotherapy in pregnancy

Kateřina Malá-Ládová, Eliška Rožníčková, Petra Rozsívalová

Čes. slov. farm. 2025, 74(2):108-113 | DOI: 10.36290/csf.2025.015

Pregnancy is a unique period requiring careful assessment of safety and effectiveness of pharmacotherapeutic interventions regarding the mother and foetus. The main source of information on the choice of a drug in pregnancy is usually the summary of product information, which often offers only brief general information and encourages excessive caution. The aim of this article is therefore a narrative overview of available professional information resources on medication use during pregnancy, which can be utilized in the care of pregnant women taking medicines. It demonstrates national and international monographs, biomedical databases, clinical guidelines,...

Good storage practices for medical devices and in vitro diagnostic medical devices by healthcare providers

Pavla Justová

Čes. slov. farm. 2025, 74(2):114-116 | DOI: 10.36290/csf.2025.016

To maintain the quality of medical devices and in vitro diagnostic medical devices used in the provision of healthcare, one of the important factors is also the fulfillment of the conditions for their storage set by the manufacturer. Healthcare providers are required to adhere to good storage practices, which are controlled by the State Institute for Drug Control. The aim of this article is to familiarize themselves with the requirements of good storage practices, which are required and controlled by the regulatory authority.

Self-treatment options for gynecological issues

Nina Netíková, Táňa Ryantová

Čes. slov. farm. 2025, 74(2):117-125 | DOI: 10.36290/csf.2025.017

Gynecological issues such as itching, discharge, burning, or dryness are common reasons for seeking medical attention. However, with the wide availability of over-the-counter medications, self-treatment is becoming increasingly relevant. This review article summarizes the most frequent vaginal complaints - vaginal candidiasis, bacterial vaginosis, aerobic vaginitis, mucosal dryness, and genital herpes - and outlines treatment options available within the scope of pharmaceutical care. It highlights the pharmacist's role in educating patients, recommending appropriate therapies, and identifying cases that require medical evaluation. The text also includes...

Repellents and protection against insects and ticks

Irena Bumbalíková

Čes. slov. farm. 2025, 74(2):126-132 | DOI: 10.36290/csf.2025.018

Mosquitoes, ticks and various other types of annoying insects are often carriers of serious and life-threatening diseases, for this reason it is advisable to protect yourself against them. Repellents are an effective protection. The aim of this article is to introduce you to the substances most often used in repellents, to warn you about their correct use and to create an overview of the preparations used in the Czech Republic. Repellents containing DEET, icaridin, IR3535 and citridiol are, when used correctly, effective and safe means of protection against insects.

Photoprotection

Zuzana Hajšelová

Čes. slov. farm. 2025, 74(2):133-135 | DOI: 10.36290/csf.2025.019

A significant factor for skin cancer development and premature aging of the skin is undesirable effect of the ultraviolet (UV) radiation. Therefore, appropriate sunprotection method is important. The highest endogenic risk factors are in people with phototype I and II.

Cestovatelský průjem - příčiny, léčba a prevence

Marcela Stibůrková

Čes. slov. farm. 2025, 74(2):136-138