Role Subkatedry klinické farmacie v systému specializačního vzdělávání farmaceutů v České republice

PharmDr. Martina Maříková, Ph.D.

Čes. slov. farm. 2025, 74(4):219

Treatment of arterial hypertension in children and adolescents

Eva Klásková, Sabina Kaprálová, Alžběta Palátová, Josef Vičar, Blažena Ševčíková

Čes. slov. farm. 2025, 74(4):222-227 | DOI: 10.36290/csf.2025.035

Arterial hypertension (AH) is a serious health problem that begins in childhood and adolescence and contributes significantly to the early development of ischemic heart disease in adulthood. The prevalence of AH in childhood is approximately 2-5 %. Secondary aetiology of AH is significantly more common in children than in adults. Within paediatric populations, primary AH treatment regimens prioritise non-pharmacological interventions. The selection of an appropriate antihypertensive treatment is dependent on the underlying aetiology of hypertension, whilst also considering the presence of any concomitant comorbidities.

Efficacy of quercetin and the role of endothelial protection in the treatment of patients with arterial hypertension

Valentyna Volodymyrivna Chopyak, Igor Grygorovich Hayduchok, Yuriy Volodymyrovych Fedorov, Alona Vasylivna Kovpak, Bogdana Fedorivna Baida, Oksana Volodymyrivna Levytska, Volodymyr Antonovych Doroshko

Čes. slov. farm. 2025, 74(4):E2-E7 | DOI: 10.36290/csf.2025.036

Introduction: The article presents the findings of a clinical trial investigating the impact of quercetin, as an adjunct to antihypertensive therapy, on endothelial function and daily blood pressure profiles. The aim of the study. To conduct a comparative analysis of the impact of quercetin on 24-hour blood pressure monitoring parameters and cytokine profiles in patients with hypertension. Materials and methods: A total of 120 patients with stage II hypertension (66 female and 54 male) were enrolled in the study. Patients were divided into 2 groups: Group I (study) – 58 patients who took quercetin (Corvitin®) in...

Organizational challenges and benefits of electronic prescriptions in physicians’ daily practice: Survey findings from Ukraine

Uliana Khomut, Iryna Fediak

Čes. slov. farm. 2025, 74(4):E8-E14 | DOI: 10.36290/csf.2025.037

Background: Electronic prescriptions (e-prescriptions) are a key element of the digital transformation of Ukraine’s healthcare system. However, their implementation and usage levels vary significantly depending on the physician’s specialty, years of experience, and the type of locality. This study is relevant due to the need for empirical analysis of these differences to improve the e-prescription system and enhance its overall efficiency. Objective: To assess the impact of e-prescriptions on the workflow of physicians from various specialties and to identify patterns associated with location, professional experience,...

The role of the pharmacist in the management of anticoagulant therapy with warfarin - literature review

Stanislav Gregor, Josef Malý

Čes. slov. farm. 2025, 74(4):230-237 | DOI: 10.36290/csf.2025.038

Introduction and aim: Warfarin treatment is associated with the risk of bleeding and thrombotic events. Although it is used less frequently, it still holds an important position in a specific patient population. Therefore, it is necessary to find ways to improve the management of its administration. One option is the implementation of a pharmacist in the anticoagulation team. The aim of the work is to provide a literature review of the role and contribution of the pharmacist in the anticoagulation management of warfarin and the possibilities of pharmacist implementation in the anticoagulation team. Methods: When searching for suitable works, the PubMed...

Radiopharmaceutical ⁶⁸Ga-PSMA-11 for prostate cancer diagnostics

Michal Budinský, Ján Melicherík, Petr Vyšinský

Čes. slov. farm. 2025, 74(4):238-242 | DOI: 10.36290/csf.2025.039

Introduction: Radiopharmaceutical ⁶⁸Ga-PSMA-11 represents gallium-68 radiolabeled peptide, molecular target for prostate-specific membrane antigen (PSMA) in prostate cancer. Objective: The aim of this paper is to describe the experience with this radiopharmaceutical in view of radiopharmaceutical technology of preparation and radiopharmaceutical analysis. Methods: This work studies and evaluates quality parameters of radiopharmaceutical ⁶⁸Ga-PSMA-11. Results: Quality parameters of radiopharmaceutical ⁶⁸Ga-PSMA-11 prepared at our department from kits for radiopharmaceutical and radionuclide generator ⁶⁸Ge/⁶⁸Ga...

Choosing wisely in practice: How sick day rules help prevent medication-related complications

Petra Rozsívalová, Petra Šubrtová, Karolína Russ, Petr Grenar, Jiří Nový, Dan Rakušan, Jiří Cyrany, Kateřina Langmaierová

Čes. slov. farm. 2025, 74(4):244-251 | DOI: 10.36290/csf.2025.040

Introduction and Aim: Sick Day Rules represent a practical multidisciplinary procedure for temporarily adjusting or suspending certain medications during an acute illness to prevent drug-related complications, especially acute kidney injury. This article aims to introduce the international concept of Sick Day Rules and proposes its application in Czech clinical practice. Methods: Literature search and analysis in the PubMed and Google Scholar databases using keywords focused on Sick Day Rules, prevention of medication-related complications, and medicine re-initiation during acute illness. Resources used included consensus documents, clinical reviews,...

Bioactive compounds with adjuvant therapeutic potential in neurodegenerative diseases and peripheral neuropathy

Alice Sychrová

Čes. slov. farm. 2025, 74(4):258-262 | DOI: 10.36290/csf.2025.042

Introduction: Neurodegenerative diseases and peripheral neuropathies share several common pathophysiological mechanisms, including oxidative stress, neuroinflammation, and mitochondrial dysfunction. Although their clinical manifestations differ, similar neuroprotective therapeutic approaches are applied in both conditions. Aim: The aim of this review is to summarize current knowledge on the use of nutraceuticals and vitamin supplementation as adjuvant strategies in the prevention and treatment of neurodegenerative diseases and peripheral neuropathies. Methods: The literature review focused on studies evaluating the efficacy, mechanisms of action,...

Self-treatment of cough in respiratory infections

Hana Kotolová

Čes. slov. farm. 2025, 74(4):264-271 | DOI: 10.36290/csf.2025.043

Cough is one of the most common symptoms with which patients search pharmaceutical care. Most cases have a viral etiology and do not require medical intervention, therefore the pharmacist has a key role in patient education and in recommending appropriate self-treatment. Correct differentiation of the type of cough and selection of appropriate treatment can significantly shorten the duration of the problem and prevent further complications. For dry cough, short-term administration of antitussives is appropriate, while for wet cough, mucolytics or expectorants are recommended. Regimen measures are also an integral part of self-treatment.

Topical application of vitamin C and its derivatives in dermatology and cosmetics

Hana Hořavová, Kateřina Brückner

Čes. slov. farm. 2025, 74(4):272-275 | DOI: 10.36290/csf.2025.044

Vitamin C (ascorbic acid) is a highly valued bioactive substance with extensive use in dermatology and cosmetics. Its main effects are strong antioxidant capacity, collagen synthesis boosting, depigmentation effect and improvement of the skin barrier. Due to these properties, it is a popular ingredient in preparations intended for the prevention of aging and correction of photodamage. Despite its biological efficacy, topical use of vitamin C represents a technological challenge due to its low stability and limited ability to penetrate the skin. The work summarizes the key factors influencing its efficacy - including concentration, pH, formulation and...

Selected case reports from the practice of a clinical pharmacist in the field of pneumology

Blanka Pelantová, Petra Halvová, Petra Rozsívalová, Lenka Dejdarová, Vladimír Koblížek, Filip Gabalec, Josef Malý

Čes. slov. farm. 2025, 74(4):252-257 | DOI: 10.36290/csf.2025.041

This article presents three case studies highlighting complex pharmacotherapeutic challenges and the role of a clinical pharmacist in clinical practice. The first case describes the long-term treatment of avian mycobacteriosis (MAC - Mycobacterium avium complex) in a patient with cystic fibrosis. It details the patient's history of multi-drug resistant MAC infection, numerous antituberculosis regimens, and significant drug intolerances, emphasizing the need for careful consideration of drug interactions, particularly with cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The second case focuses on the management of a drug...

I „kosmetická“ změna v terapii arteriální hypertenze může přinést velký (a ne vždy chtěný) klinický účinek

MUDr. Pavel Rutar

Čes. slov. farm. 2025, 74(4):276-278