Čes. slov. farm. 2025, 74(2):84-89 | DOI: 10.36290/csf.2025.011

Current trends in insulin therapy

Kateřina Štechová

Interní oddělení Nemocnice Na Františku, Praha

In January 2025, 103 years have passed since the injection of insulin saved the life of the first patient with type 1 diabetes mellitus. The aim of the article is to familiarize readers with current insulin therapy, which is an essential treatment modality for patients with type 1 diabetes, but also for many patients with other types of diabetes mellitus. The current treatment of patients with type 1 diabetes consists of using 2^nd generation insulin analogues, either rapid in insulin pumps, which now also have the so-called hybrid closed-loop function, or patients apply a rapid analogue in combination with a basal analogue by insulin pens. Adjusting insulin doses according to data from glucose sensors has become a common praxis. Patients with type 2 diabetes also use modern insulin therapy. They can especially benefit from formulas that combine a basal insulin analogue with a GLP-1 receptor agonist. In addition, 3^rd generation basal insulin analogues with application only once a week are approaching clinical practice. This can significantly help simplify the logistics of insulin therapy and thus improve adherence to treatment for at least certain groups of patients.

Keywords: insulin analogues, insulin resistance, diabetes, insulin, insulin administered once a week.

Accepted: May 28, 2025; Published: June 18, 2025  Show citation