The immunomodulatory activity of the extracts and complexes of biologically active compounds of Galium verum L. herb

Igor L. Shinkovenko, Natalia V. Kashpur, Tatiana V. Ilyina, Alla M. Kovalyova, Olga V. Goryacha, Oleh M. Koshovyi, Erica L. Toryanyk, Olena V. Kryvoruchko

Čes. slov. farm. 2018, 67(1):25-29 | DOI: 10.36290/csf.2018.003  

The present article discusses the results of an immunomodulatory activity of Galii veri herba, Galium verum herb (Galium verum L., Rubiaceae) fluid water extract and the effect of the polysaccharide and phenolic complexes of the letter on the immunomodulatory activity. The same extract was fractionated into a polysaccharide complex (PSC) and a polyphenolic complex (PPC). In the obtained substances, the contents of hydroxycinnamic derivates, flavonoids and polyphenols were determined spectrophotometrically; polysaccharides were quantified gravimetrically; the immunomodulatory activity of the substances was determined in the reaction of...

Genistein: a promising molecule modulating tumour growth and wound healing?

Petra Mitrengová, Pavel Mučaji, Vlasta Peržeľová, Erik Dosedla, Peter Gál

Čes. slov. farm. 2018, 67(1):3-13 | DOI: 10.36290/csf.2018.001  

Although it has been shown that oestrogen replacement therapy is able to improve wound healing, several side effects of this replacement therapy have precluded its common use in clinical practice. On the other hand, the phytoestrogen genistein (the selective oestrogen receptor modulator belonging to the group of isoflavones) has been introduced into several clinical trials to improve cancer treatment efficiency and experiments suggest its positive effect on wound healing. The main mechanisms of action, which have been elucidated so far, include induction of apoptosis, cell cycle arrest, inhibition of angiogenesis and tyrosine kinase activity as well...

Liberalization and integration of drug distribution in the EU 28 and Norway

Jaroslav Písek, Kamil Pícha

Čes. slov. farm. 2018, 67(1):14-24 | DOI: 10.36290/csf.2018.002  

The pharmaceutical distribution system in Europe is undergoing a long-term change. Wholesale companies join together to form both horizontally and vertically integrated structures. Pharmacies, formerly owned almost exclusively by pharmacists, are becoming part of the chain thanks to the liberalization of operating conditions. Chains are expanding successfully due to economies of scale and purchasing power for negotiation with suppliers. Independent pharmacies are becoming part of virtual chains to better compete with chains. An assortment previously reserved to pharmacies is also marketed in food stores or gas pumps due to legislative changes. E-pharmacies...

Pharmacy and Johann Wolfgang von Goethe: Pharmacists as Goethe's chemistry teaches

Radek Chalupa, Karel Nesměrák

Čes. slov. farm. 2018, 67(1):32-44 | DOI: 10.36290/csf.2018.005  

At the turn of the 18^th and 19^th centuries, when pharmacy was established as a modern scientific discipline, pharmacists played an important role in spreading the latest discoveries in the field of chemistry, being virtually the only established representatives of the field. The article focuses on a mutually enriching dialogue between the prominent personality of the time - the poet, writer and statesman, as well as the scientist - Johann Wolfgang von Goethe and the major representatives of the pharmacy of that time, especially J. R. Spielmann, W. H. Buchholz, J. F. Göttling, and J. W. Döbereiner. Goethe, who has been deeply interested...

Nové knihy

J. Čižmárik

Čes. slov. farm. 2018, 67(1):45  

Theory and practice of pharmacopoeial control of the quality of drugs and excipients VII. The colour reference solutions of the European pharmacopoeia (Ph. Eur.)

Jan Šubert, Jozef Kolář, Jozef Čižmárik

Čes. slov. farm. 2018, 67(1):30-31 | DOI: 10.36290/csf.2018.004  

Data calculations of three different workplaces consistently show that the difference in colour ΔE (CIELAB) of some colour reference solutions according to Ph. Eur. with small colour and purified water are too small. As a result, there is failure with use of these solutions for visual assessment of the coloration of the liquids. Solving the problem in Ph. Eur. presupposes the introduction of instrumental colour evaluation into this pharmacopoeia.