The size-reduced Eudragit^® RS microparticles prepared by solvent evaporation method - monitoring the effect of selected variables on tested parameters

Kalliopi Vasileiou, Jakub Vysloužil, Miroslava Pavelková, Jan Vysloužil, Kateřina Kubová

Čes. slov. farm. 2017, 66(6):274-280 | DOI: 10.36290/csf.2017.039  

Size-reduced microparticles were successfully obtained by solvent evaporation method. Different parameters were applied in each sample and their influence on microparticles was evaluated. As a model drug the insoluble ibuprofen was selected for the encapsulation process with Eudragit^® RS. The obtained microparticles were inspected by optical microscopy and scanning electron microscopy. The effect of aqueous phase volume (600, 400, 200 ml) and the concentration of polyvinyl alcohol (PVA; 1.0% and 0.1%) were studied. It was evaluated how those variations and also size can affect microparticle characteristics such as encapsulation efficiency,...

Development of dissolution method for warfarin sodium tablets

Ivana Lukášová, Jan Muselík, Aleš Franc

Čes. slov. farm. 2017, 66(6):281-286 | DOI: 10.36290/csf.2017.040  

Warfarin is intensively discussed drug with narrow therapeutic index. In the past, its generic substitution was identified as a cause of bleeding. Altered quality of the active substance or varying drug content was discussed. The substance quality can be evaluated with adequate dissolution method. An official dissolution method with aqueous medium exists, however this method is non-discriminatory. In the first 15 minutes the whole amount of the active pharmaceutical ingredient is released from a tested dosage form, which does not allow comparison between tablets from different producers and it also makes difficult to track the changes throughout stability...

Gut microbiota: its development and relation to certain diseases

Hana Kiňová Sepová, Boris Dudík, Andrea Bilková

Čes. slov. farm. 2017, 66(6):267-273 | DOI: 10.36290/csf.2017.038  

Coexistence of humans with microorganisms is well known for a long time. Besides the association with infectious diseases, personal microbiota is important for human health, possibly for some non-infectious diseases. Colonization of the human body with appropriate microorganisms after delivery is essential for physiological immune system maturation and also has an influence on central nervous system development. The composition of the gut microbiota is affected by the mode of delivery, early life nutrition and last but not least by lifestyle and drug, especially antibiotics intake. A comparison of gut microbiomes between individuals living in different...

Sympozia Sekce dějin farmacie ČFS v roce 2017

Čes. slov. farm. 2017, 66(6):290-295  

Zpráva z mezinárodního setkání historiků farmacie ve Varšavě

Tünde Ambrus

Čes. slov. farm. 2017, 66(6):296  

Carboxylic acids from brown algae Fucus vesiculosus and Padina pavonica

Elena Krivoruchko, Hussein Kanaan, Victoria Samoilova, Tetiana Ilyina, Oleh Koshovyi

Čes. slov. farm. 2017, 66(6):287-289 | DOI: 10.36290/csf.2017.041  

Using the gas chromatographic-mass spectrometric method, the content of 28 carboxylic acids was determined in the thalli of Fucus vesiculosus, palmitic, oxalic and malic acids predominating. In the thalli of Padina pavonica, the content of 27 carboxylic acids was determined. Palmitic, oxalic and oleic acids prevail.

Autorský rejstřík

Čes. slov. farm. 2017, 66(6):299-300